GREMLIN Database
DUF4834 - Domain of unknown function (DUF4834)
PFAM: PF16118 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 99 (93)
Sequences: 2704 (2379)
Seq/√Len: 246.7
META: 0.851

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_G71_I3.3221.00
14_L18_G2.6231.00
16_Y20_K2.4321.00
68_E71_I2.4251.00
22_L26_F2.1761.00
24_R28_P2.0041.00
19_L23_R2.0031.00
65_K68_E1.8271.00
9_I13_L1.8251.00
42_A45_K1.8161.00
43_Q47_Q1.7211.00
11_I15_I1.6431.00
67_G70_I1.6211.00
28_P31_G1.5781.00
23_R27_R1.5661.00
24_R27_R1.5621.00
86_S89_V1.5441.00
45_K49_Q1.5391.00
27_R31_G1.5281.00
46_F49_Q1.5261.00
42_A46_F1.5221.00
13_L17_Y1.4871.00
8_L12_I1.4801.00
49_Q52_Q1.4511.00
20_K24_R1.3891.00
41_K44_K1.3791.00
21_I24_R1.3631.00
47_Q51_Q1.3421.00
18_G22_L1.3381.00
15_I19_L1.3351.00
10_L14_L1.3151.00
35_R39_S1.3081.00
34_R38_A1.3021.00
23_R26_F1.2901.00
20_K23_R1.2631.00
72_D75_P1.1901.00
20_K28_P1.1371.00
26_F30_F1.1261.00
8_L15_I1.1261.00
64_K69_V1.1191.00
41_K45_K1.1121.00
41_K46_F1.1111.00
45_K48_Q1.0991.00
73_K76_K1.0881.00
48_Q52_Q1.0851.00
67_G72_D1.0441.00
51_Q54_Q1.0391.00
46_F50_F1.0391.00
62_Q65_K1.0391.00
15_I18_G1.0101.00
17_Y21_I1.0081.00
48_Q51_Q1.0081.00
25_L28_P1.0041.00
81_R86_S0.9931.00
59_Q62_Q0.9701.00
43_Q46_F0.9541.00
66_E70_I0.9381.00
4_L7_L0.9341.00
22_L25_L0.9321.00
66_E71_I0.9321.00
47_Q50_F0.9321.00
19_L24_R0.9221.00
51_Q55_Q0.9181.00
66_E69_V0.9131.00
71_I74_K0.9091.00
5_G9_I0.8941.00
44_K47_Q0.8911.00
17_Y20_K0.8801.00
89_V92_Y0.8750.99
23_R29_L0.8740.99
64_K67_G0.8700.99
53_Q56_Q0.8540.99
43_Q49_Q0.8350.99
21_I25_L0.8130.99
90_G93_V0.8080.99
37_K40_K0.8050.99
87_K90_G0.7930.99
57_Q60_R0.7910.99
23_R28_P0.7830.99
44_K48_Q0.7820.99
14_L24_R0.7750.99
69_V72_D0.7680.99
74_K77_K0.7620.99
23_R31_G0.7600.99
18_G26_F0.7420.98
6_F14_L0.7360.98
11_I18_G0.7360.98
6_F15_I0.7280.98
76_K79_K0.7270.98
19_L26_F0.7260.98
6_F10_L0.7220.98
68_E74_K0.7200.98
64_K74_K0.7090.98
90_G97_E0.6980.98
10_L13_L0.6970.98
64_K70_I0.6950.97
36_K39_S0.6880.97
74_K99_K0.6840.97
69_V73_K0.6820.97
40_K43_Q0.6810.97
89_V99_K0.6810.97
65_K71_I0.6740.97
53_Q57_Q0.6720.97
10_L18_G0.6670.97
4_L8_L0.6660.97
58_Q61_Q0.6580.96
86_S95_F0.6560.96
63_T66_E0.6460.96
67_G75_P0.6430.96
52_Q55_Q0.6420.96
17_Y24_R0.6360.96
80_K86_S0.6330.96
30_F38_A0.6290.95
11_I14_L0.6130.95
10_L15_I0.6110.95
11_I24_R0.6110.95
33_G37_K0.6010.94
7_L11_I0.5940.94
12_I17_Y0.5920.94
40_K44_K0.5830.93
70_I73_K0.5800.93
57_Q62_Q0.5770.93
83_K88_D0.5760.93
6_F16_Y0.5730.93
13_L19_L0.5600.92
49_Q53_Q0.5590.92
5_G14_L0.5580.92
54_Q58_Q0.5530.91
13_L18_G0.5470.91
67_G73_K0.5420.90
52_Q56_Q0.5400.90
33_G36_K0.5360.90
16_Y28_P0.5290.89
38_A42_A0.5270.89
47_Q53_Q0.5220.89
64_K68_E0.5200.89
20_K26_F0.5150.88
37_K42_A0.5110.88
11_I17_Y0.5110.88
61_Q64_K0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4um9B 2 0 27.9 0.851 Contact Map
2w1kA 1 0 11 0.876 Contact Map
5a2fA 1 0 10.8 0.877 Contact Map
2l16A 1 0.4848 10.2 0.878 Contact Map
4cylA 1 0.0101 8.5 0.882 Contact Map
3lb6C 1 0 7.4 0.885 Contact Map
1cd1A 1 0 7.1 0.886 Contact Map
3oduA 2 0.9596 6.7 0.888 Contact Map
1pi7A 1 0.1919 6.5 0.888 Contact Map
3j0cA 4 0.3636 5.7 0.891 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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