GREMLIN Database
DUF4833 - Domain of unknown function (DUF4833)
PFAM: PF16117 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 138 (138)
Sequences: 2112 (1719)
Seq/√Len: 146.3
META: 0.929

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_D33_Y3.2551.00
95_I100_A3.0681.00
79_I91_A3.0351.00
123_E138_R3.0231.00
83_K89_Y2.5891.00
128_D131_T2.5721.00
6_S109_A2.5171.00
6_S108_K2.4741.00
98_K128_D2.3991.00
16_A24_L2.1981.00
100_A135_V2.1691.00
108_K120_E2.1651.00
90_R101_I2.1501.00
9_A38_A2.1301.00
4_Q11_T2.1161.00
69_L91_A2.0241.00
68_E78_P2.0221.00
39_E42_Q1.9201.00
77_R137_E1.9151.00
19_D23_K1.8251.00
103_E127_T1.8181.00
11_T37_Y1.7771.00
26_P61_P1.7221.00
110_E120_E1.7211.00
125_F136_Y1.6941.00
70_R78_P1.6911.00
15_D31_H1.6491.00
31_H43_R1.6251.00
108_K121_Y1.6221.00
2_Y11_T1.6151.00
123_E136_Y1.5991.00
7_K109_A1.5911.00
36_R50_Q1.5611.00
36_R44_E1.5361.00
61_P67_Y1.5211.00
101_I129_L1.5011.00
47_N50_Q1.4491.00
31_H45_E1.4301.00
17_N31_H1.4091.00
19_D25_D1.4021.00
32_V46_L1.3621.00
5_R8_N1.3421.00
66_S82_R1.3341.00
32_V57_I1.3291.00
81_L91_A1.3001.00
17_N25_D1.2741.00
102_L105_I1.2661.00
94_T99_P1.2441.00
77_R124_L1.2211.00
112_G115_W1.2151.00
19_D26_P1.1761.00
104_R125_F1.1731.00
68_E80_T1.1370.99
36_R47_N1.1290.99
84_D90_R1.1260.99
3_I55_Y1.1210.99
36_R39_E1.1160.99
36_R42_Q1.1080.99
4_Q104_R1.1080.99
28_E31_H1.1060.99
66_S80_T1.0960.99
127_T134_P1.0890.99
4_Q106_Y1.0840.99
95_I126_G1.0700.99
77_R93_T1.0620.99
12_V34_W1.0560.99
2_Y13_V1.0450.99
63_G66_S1.0390.99
30_V81_L1.0190.99
16_A89_Y1.0170.99
30_V69_L1.0170.99
82_R99_P0.9930.99
44_E47_N0.9760.98
69_L79_I0.9640.98
26_P67_Y0.9480.98
5_R12_V0.9440.98
79_I102_L0.9380.98
55_Y73_A0.9340.98
46_L50_Q0.9280.98
111_G117_P0.9270.98
59_V69_L0.9140.98
60_K68_E0.9130.98
101_I127_T0.8970.97
7_K11_T0.8940.97
38_A42_Q0.8920.97
125_F134_P0.8770.97
4_Q37_Y0.8740.97
58_K72_V0.8690.97
25_D28_E0.8610.96
50_Q57_I0.8590.96
128_D133_K0.8460.96
8_N45_E0.8460.96
102_L124_L0.8280.96
3_I6_S0.8250.96
57_I71_L0.8120.95
82_R92_Y0.7870.94
111_G120_E0.7800.94
3_I14_Y0.7770.94
37_Y41_G0.7750.94
121_Y138_R0.7730.94
74_Y105_I0.7710.94
5_R9_A0.7690.94
128_D135_V0.7550.93
13_V37_Y0.7530.93
2_Y37_Y0.7520.93
6_S106_Y0.7510.93
92_Y99_P0.7470.93
10_N50_Q0.7450.92
12_V36_R0.7440.92
111_G115_W0.7440.92
44_E107_V0.7410.92
5_R34_W0.7410.92
27_K75_K0.7370.92
83_K88_K0.7340.92
30_V57_I0.7320.92
27_K60_K0.7280.92
107_V121_Y0.7200.91
59_V62_I0.7170.91
112_G117_P0.7160.91
7_K10_N0.7160.91
47_N51_R0.7130.91
42_Q50_Q0.7090.90
36_R41_G0.7060.90
84_D87_G0.7040.90
16_A83_K0.7030.90
48_F52_K0.7030.90
16_A30_V0.7020.90
110_E114_F0.7000.90
84_D88_K0.7000.90
62_I65_G0.6980.90
107_V116_L0.6810.89
112_G116_L0.6780.88
127_T132_G0.6750.88
52_K72_V0.6680.88
83_K87_G0.6660.87
77_R100_A0.6620.87
57_I69_L0.6610.87
5_R109_A0.6570.87
92_Y129_L0.6460.86
70_R75_K0.6400.85
62_I66_S0.6390.85
13_V33_Y0.6310.85
84_D101_I0.6310.85
103_E134_P0.6280.84
74_Y77_R0.6280.84
23_K61_P0.6260.84
54_A67_Y0.6200.84
128_D132_G0.6150.83
111_G114_F0.6150.83
96_N137_E0.6140.83
100_A124_L0.6090.82
71_L122_V0.6040.82
71_L75_K0.6010.82
96_N135_V0.6010.82
49_I111_G0.5970.81
84_D92_Y0.5970.81
11_T15_D0.5900.80
1_F5_R0.5900.80
55_Y72_V0.5890.80
126_G129_L0.5890.80
95_I137_E0.5870.80
63_G68_E0.5860.80
60_K70_R0.5820.80
113_S122_V0.5820.80
11_T16_A0.5800.79
20_A27_K0.5790.79
36_R45_E0.5770.79
34_W117_P0.5720.78
12_V105_I0.5720.78
14_Y32_V0.5680.78
61_P64_N0.5650.78
10_N36_R0.5640.77
93_T102_L0.5620.77
39_E44_E0.5600.77
78_P93_T0.5580.77
15_D22_G0.5530.76
82_R101_I0.5520.76
50_Q89_Y0.5520.76
35_I43_R0.5460.75
39_E46_L0.5450.75
48_F53_F0.5450.75
31_H57_I0.5440.75
35_I41_G0.5430.75
42_Q45_E0.5430.75
35_I89_Y0.5430.75
62_I68_E0.5430.75
46_L108_K0.5420.75
82_R90_R0.5420.75
10_N38_A0.5370.74
98_K130_A0.5360.74
24_L93_T0.5340.73
53_F119_V0.5330.73
13_V17_N0.5330.73
75_K79_I0.5320.73
2_Y67_Y0.5290.73
15_D35_I0.5240.72
13_V18_L0.5190.71
107_V122_V0.5190.71
120_E123_E0.5180.71
3_I13_V0.5160.71
28_E82_R0.5160.71
79_I93_T0.5120.70
77_R97_G0.5090.70
121_Y136_Y0.5070.70
109_A112_G0.5050.69
53_F116_L0.5020.69
49_I136_Y0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1uebA 1 0.3768 9.2 0.935 Contact Map
3cpfA 1 0.3913 8.5 0.936 Contact Map
3a5zB 1 0.3768 7.2 0.939 Contact Map
3oyyA 1 0.3986 7.1 0.939 Contact Map
3treA 1 0.3768 6.1 0.94 Contact Map
3f6yA 2 0.6667 5.5 0.942 Contact Map
1bkbA 3 0.442 4.7 0.944 Contact Map
3payA 4 0.3768 3.8 0.946 Contact Map
1isiA 2 0.6667 3.6 0.947 Contact Map
1khiA 1 0.413 3.1 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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