DUF4831 - PFAM28P - GREMLIN Contacts

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DUF4831 - Domain of unknown function (DUF4831)

PFAM:	PF16115	Sequences: EGVVYSLPKTVLRVTVEAEKTTYKPGPYAKYAEKYLGIKDVITEDSTSYEIKSIKITTYGEPDPSQVYVVEFKSKTVAPFLSLTEDGLLLAINAEPEPEEEEPPPFKPAPKSLKTLNPRDYLTEEILVAKSTAKKAEEAAKQIYEIRESRNDLLTGEADNMPPDGEALKLMLDELDRQEKAYLSLFTGKTTTETQTYTFTVIPDKEVKKEVLFRFSEKLGIVDADDLSGEPVYIELKPLETTPALVPKEAEKKKKKKGGLYYRIPGKANVTISDGNKTLASGRVPIAQFGTVESLPPNLFNKKAPTKVEFDPETGAIK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	318 (313)
Sequences:	1634 (1384)
Seq/√Len:	78.2
META:	0.928

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
25_P	45_D	6.330	1.00
146_I	175_L	4.929	1.00
166_E	169_K	4.070	1.00
174_E	177_R	3.829	1.00
19_E	52_K	3.706	1.00
213_F	232_V	3.487	1.00
169_K	173_D	3.365	1.00
56_I	280_A	3.232	1.00
16_V	213_F	3.214	1.00
214_R	229_G	3.206	1.00
33_E	39_K	3.027	1.00
23_Y	42_I	2.986	1.00
19_E	50_E	2.886	1.00
137_E	141_K	2.837	1.00
20_K	193_E	2.737	1.00
38_I	41_V	2.603	1.00
66_Q	263_R	2.528	1.00
18_A	49_Y	2.518	1.00
24_K	45_D	2.517	1.00
15_T	196_T	2.512	1.00
12_L	286_I	2.424	1.00
38_I	187_T	2.412	1.00
13_R	59_Y	2.300	1.00
20_K	47_T	2.298	1.00
148_E	152_D	2.262	1.00
117_N	120_D	2.214	1.00
18_A	197_Y	2.212	1.00
153_L	171_M	2.080	1.00
130_K	138_E	2.078	1.00
92_I	260_L	2.072	1.00
23_Y	190_T	2.070	1.00
70_V	260_L	2.053	1.00
149_S	152_D	2.039	1.00
12_L	284_V	1.957	1.00
13_R	200_T	1.949	1.00
17_E	194_T	1.945	1.00
235_E	271_T	1.926	1.00
278_T	281_S	1.887	1.00
6_S	67_V	1.873	1.00
9_K	61_E	1.872	1.00
149_S	155_T	1.844	1.00
268_A	286_I	1.844	1.00
15_T	198_T	1.795	1.00
147_R	179_E	1.792	1.00
173_D	176_D	1.791	1.00
261_Y	292_V	1.773	1.00
68_Y	292_V	1.760	1.00
151_N	155_T	1.729	1.00
19_E	192_T	1.723	1.00
178_Q	182_Y	1.707	1.00
267_K	283_R	1.677	1.00
51_I	215_F	1.672	1.00
201_V	234_I	1.650	1.00
11_V	202_I	1.629	1.00
139_A	185_L	1.612	1.00
152_D	158_A	1.604	1.00
12_L	58_T	1.599	1.00
13_R	57_T	1.595	1.00
176_D	180_K	1.593	1.00
13_R	198_T	1.583	1.00
49_Y	195_Q	1.572	0.99
17_E	53_S	1.570	0.99
15_T	55_K	1.563	0.99
18_A	221_I	1.532	0.99
21_T	192_T	1.521	0.99
154_L	171_M	1.518	0.99
234_I	272_I	1.510	0.99
150_R	176_D	1.508	0.99
56_I	270_V	1.498	0.99
89_L	310_F	1.496	0.99
91_A	94_A	1.490	0.99
16_V	54_I	1.483	0.99
134_K	137_E	1.482	0.99
168_L	171_M	1.480	0.99
236_L	270_V	1.473	0.99
22_T	193_E	1.463	0.99
15_T	57_T	1.458	0.99
153_L	167_A	1.456	0.99
219_L	228_S	1.452	0.99
142_Q	145_E	1.440	0.99
5_Y	8_P	1.438	0.99
84_T	90_L	1.435	0.99
14_V	272_I	1.434	0.99
2_G	69_V	1.430	0.99
60_G	313_E	1.421	0.99
210_E	234_I	1.412	0.99
27_P	37_G	1.411	0.99
212_L	234_I	1.390	0.99
23_Y	46_S	1.386	0.99
230_E	274_D	1.383	0.99
201_V	210_E	1.370	0.99
311_D	314_T	1.362	0.99
158_A	162_P	1.358	0.99
3_V	81_L	1.357	0.98
214_R	228_S	1.353	0.98
212_L	272_I	1.351	0.98
17_E	52_K	1.338	0.98
214_R	231_P	1.326	0.98
10_T	287_A	1.311	0.98
17_E	196_T	1.289	0.98
12_L	56_I	1.283	0.98
82_S	91_A	1.281	0.98
238_P	241_T	1.276	0.98
14_V	212_L	1.272	0.98
150_R	172_L	1.265	0.98
9_K	64_P	1.265	0.98
222_V	228_S	1.259	0.98
114_K	120_D	1.251	0.97
237_K	269_N	1.241	0.97
261_Y	294_S	1.241	0.97
179_E	183_L	1.239	0.97
237_K	271_T	1.236	0.97
116_L	120_D	1.227	0.97
20_K	49_Y	1.226	0.97
211_V	231_P	1.192	0.97
214_R	226_D	1.185	0.96
31_Y	133_A	1.175	0.96
269_N	281_S	1.168	0.96
270_V	284_V	1.166	0.96
16_V	51_I	1.162	0.96
151_N	175_L	1.160	0.96
162_P	168_L	1.147	0.96
230_E	275_G	1.136	0.95
308_V	317_I	1.132	0.95
59_Y	200_T	1.124	0.95
214_R	227_L	1.121	0.95
14_V	56_I	1.110	0.95
116_L	121_Y	1.107	0.95
115_T	120_D	1.093	0.94
114_K	121_Y	1.083	0.94
126_I	139_A	1.082	0.94
215_F	232_V	1.082	0.94
117_N	121_Y	1.080	0.94
167_A	171_M	1.078	0.94
267_K	285_P	1.070	0.94
139_A	142_Q	1.061	0.93
142_Q	155_T	1.055	0.93
236_L	268_A	1.053	0.93
21_T	48_S	1.051	0.93
263_R	292_V	1.051	0.93
184_S	189_K	1.041	0.93
173_D	177_R	1.041	0.93
25_P	30_K	1.033	0.93
11_V	200_T	1.029	0.92
122_L	125_E	1.020	0.92
4_V	69_V	1.012	0.92
158_A	167_A	1.011	0.92
52_K	194_T	1.004	0.91
121_Y	126_I	0.990	0.91
118_P	121_Y	0.975	0.90
12_L	280_A	0.968	0.90
207_V	210_E	0.964	0.90
270_V	286_I	0.963	0.90
54_I	272_I	0.957	0.89
103_P	108_P	0.945	0.89
22_T	47_T	0.944	0.89
126_I	138_E	0.938	0.88
16_V	199_F	0.936	0.88
209_K	235_E	0.931	0.88
142_Q	182_Y	0.924	0.88
34_K	133_A	0.919	0.87
184_S	187_T	0.919	0.87
172_L	176_D	0.917	0.87
254_K	258_G	0.901	0.86
153_L	168_L	0.899	0.86
28_Y	36_L	0.898	0.86
225_D	229_G	0.894	0.86
54_I	213_F	0.893	0.86
119_R	122_L	0.892	0.86
163_P	166_E	0.888	0.86
150_R	179_E	0.882	0.85
170_L	174_E	0.874	0.85
84_T	88_L	0.873	0.85
266_G	287_A	0.872	0.84
255_K	258_G	0.868	0.84
215_F	222_V	0.861	0.84
6_S	62_P	0.853	0.83
124_E	141_K	0.851	0.83
264_I	293_E	0.850	0.83
34_K	183_L	0.850	0.83
120_D	123_T	0.850	0.83
216_S	220_G	0.845	0.83
226_D	231_P	0.844	0.82
11_V	61_E	0.844	0.82
222_V	229_G	0.838	0.82
118_P	123_T	0.837	0.82
60_G	287_A	0.834	0.82
271_T	281_S	0.833	0.82
61_E	283_R	0.832	0.82
177_R	181_A	0.830	0.81
19_E	194_T	0.830	0.81
152_D	157_E	0.829	0.81
105_P	108_P	0.829	0.81
142_Q	151_N	0.826	0.81
5_Y	261_Y	0.825	0.81
61_E	64_P	0.819	0.81
76_T	80_F	0.818	0.80
149_S	158_A	0.815	0.80
144_Y	149_S	0.814	0.80
73_K	302_K	0.814	0.80
201_V	236_L	0.810	0.80
311_D	317_I	0.809	0.80
88_L	311_D	0.808	0.80
66_Q	292_V	0.806	0.80
146_I	233_Y	0.804	0.79
262_Y	310_F	0.804	0.79
307_K	317_I	0.802	0.79
106_F	109_A	0.799	0.79
209_K	233_Y	0.796	0.79
2_G	7_L	0.794	0.78
252_K	257_K	0.792	0.78
241_T	266_G	0.791	0.78
49_Y	215_F	0.789	0.78
14_V	201_V	0.789	0.78
9_K	202_I	0.779	0.77
5_Y	10_T	0.778	0.77
158_A	163_P	0.777	0.77
209_K	273_S	0.776	0.77
11_V	59_Y	0.773	0.77
26_G	186_F	0.773	0.77
153_L	160_N	0.762	0.76
164_D	169_K	0.760	0.75
215_F	220_G	0.759	0.75
157_E	168_L	0.758	0.75
114_K	119_R	0.758	0.75
242_T	245_L	0.757	0.75
35_Y	133_A	0.750	0.74
269_N	283_R	0.749	0.74
119_R	126_I	0.749	0.74
178_Q	181_A	0.749	0.74
310_F	315_G	0.747	0.74
29_A	32_A	0.741	0.74
9_K	204_D	0.741	0.74
156_G	168_L	0.738	0.73
18_A	199_F	0.738	0.73
197_Y	221_I	0.737	0.73
287_A	314_T	0.737	0.73
113_L	117_N	0.737	0.73
180_K	184_S	0.737	0.73
168_L	172_L	0.737	0.73
14_V	199_F	0.735	0.73
232_V	272_I	0.735	0.73
166_E	174_E	0.734	0.73
238_P	242_T	0.734	0.73
145_E	149_S	0.732	0.73
147_R	165_G	0.729	0.72
152_D	155_T	0.729	0.72
211_V	224_A	0.729	0.72
114_K	117_N	0.728	0.72
23_Y	45_D	0.728	0.72
158_A	172_L	0.728	0.72
76_T	79_P	0.728	0.72
27_P	138_E	0.728	0.72
251_E	254_K	0.724	0.72
120_D	124_E	0.716	0.71
234_I	270_V	0.715	0.71
183_L	187_T	0.712	0.71
138_E	182_Y	0.710	0.70
127_L	144_Y	0.710	0.70
175_L	230_E	0.704	0.70
296_P	306_T	0.700	0.69
158_A	171_M	0.698	0.69
33_E	38_I	0.696	0.69
32_A	236_L	0.695	0.69
3_V	70_V	0.695	0.69
114_K	118_P	0.694	0.69
29_A	43_T	0.694	0.69
154_L	172_L	0.693	0.68
58_T	284_V	0.691	0.68
25_P	29_A	0.689	0.68
21_T	50_E	0.689	0.68
142_Q	150_R	0.688	0.68
166_E	173_D	0.687	0.68
156_G	162_P	0.687	0.68
305_P	316_A	0.686	0.68
93_N	134_K	0.684	0.67
131_S	229_G	0.684	0.67
259_G	295_L	0.682	0.67
84_T	87_G	0.682	0.67
103_P	107_K	0.681	0.67
254_K	257_K	0.681	0.67
116_L	122_L	0.680	0.67
214_R	223_D	0.678	0.67
211_V	214_R	0.675	0.66
214_R	225_D	0.675	0.66
10_T	286_I	0.675	0.66
180_K	187_T	0.674	0.66
122_L	126_I	0.673	0.66
309_E	317_I	0.672	0.66
271_T	278_T	0.672	0.66
42_I	45_D	0.672	0.66
115_T	121_Y	0.668	0.66
171_M	197_Y	0.666	0.65
6_S	143_I	0.666	0.65
237_K	286_I	0.665	0.65
211_V	233_Y	0.664	0.65
36_L	185_L	0.662	0.65
24_K	191_T	0.662	0.65
272_I	279_L	0.661	0.65
36_L	183_L	0.661	0.65
210_E	224_A	0.660	0.65
146_I	179_E	0.659	0.65
287_A	315_G	0.659	0.65
78_A	83_L	0.658	0.64
106_F	111_K	0.658	0.64
296_P	305_P	0.657	0.64
131_S	231_P	0.657	0.64
135_K	148_E	0.656	0.64
264_I	291_T	0.654	0.64
206_E	240_E	0.652	0.64
49_Y	162_P	0.649	0.63
121_Y	124_E	0.649	0.63
72_F	83_L	0.646	0.63
20_K	195_Q	0.644	0.63
156_G	161_M	0.644	0.63
60_G	88_L	0.643	0.63
222_V	271_T	0.642	0.63
12_L	270_V	0.641	0.62
115_T	119_R	0.641	0.62
16_V	159_D	0.639	0.62
28_Y	32_A	0.637	0.62
273_S	278_T	0.637	0.62
121_Y	125_E	0.637	0.62
6_S	64_P	0.637	0.62
115_T	118_P	0.636	0.62
109_A	270_V	0.635	0.62
135_K	144_Y	0.635	0.62
251_E	258_G	0.634	0.62
172_L	278_T	0.633	0.61
119_R	123_T	0.632	0.61
129_A	147_R	0.632	0.61
129_A	162_P	0.631	0.61
86_D	215_F	0.626	0.61
222_V	227_L	0.624	0.60
27_P	151_N	0.623	0.60
15_T	159_D	0.618	0.60
123_T	126_I	0.616	0.59
218_K	228_S	0.614	0.59
36_L	139_A	0.612	0.59
230_E	235_E	0.612	0.59
130_K	263_R	0.612	0.59
89_L	294_S	0.610	0.59
269_N	282_G	0.609	0.59
86_D	267_K	0.608	0.58
79_P	89_L	0.608	0.58
146_I	150_R	0.607	0.58
239_L	244_A	0.607	0.58
139_A	152_D	0.607	0.58
82_S	96_P	0.606	0.58
235_E	273_S	0.605	0.58
273_S	276_N	0.605	0.58
94_A	309_E	0.604	0.58
248_K	254_K	0.604	0.58
164_D	167_A	0.602	0.58
116_L	119_R	0.602	0.58
102_E	105_P	0.601	0.58
131_S	134_K	0.600	0.57
165_G	186_F	0.599	0.57
260_L	263_R	0.597	0.57
198_T	202_I	0.596	0.57
131_S	140_A	0.595	0.57
129_A	225_D	0.594	0.57
221_I	317_I	0.590	0.56
100_E	112_S	0.587	0.56
211_V	226_D	0.587	0.56
181_A	189_K	0.587	0.56
307_K	310_F	0.586	0.56
232_V	274_D	0.585	0.56
239_L	242_T	0.582	0.55
100_E	103_P	0.580	0.55
201_V	207_V	0.580	0.55
132_T	135_K	0.579	0.55
250_A	255_K	0.578	0.55
308_V	313_E	0.577	0.55
211_V	222_V	0.577	0.55
117_N	125_E	0.577	0.55
38_I	144_Y	0.573	0.54
214_R	222_V	0.573	0.54
286_I	313_E	0.573	0.54
2_G	172_L	0.573	0.54
153_L	158_A	0.572	0.54
294_S	297_P	0.569	0.53
58_T	313_E	0.569	0.53
9_K	51_I	0.569	0.53
46_S	191_T	0.568	0.53
264_I	308_V	0.565	0.53
199_F	212_L	0.564	0.53
145_E	152_D	0.564	0.53
17_E	55_K	0.562	0.53
98_P	101_E	0.560	0.52
62_P	88_L	0.560	0.52
156_G	229_G	0.558	0.52
103_P	106_F	0.558	0.52
305_P	308_V	0.558	0.52
102_E	106_F	0.557	0.52
118_P	124_E	0.556	0.52
246_V	250_A	0.556	0.52
146_I	151_N	0.555	0.52
199_F	221_I	0.555	0.52
181_A	184_S	0.555	0.52
216_S	289_F	0.554	0.52
134_K	139_A	0.554	0.52
120_D	126_I	0.552	0.51
154_L	183_L	0.550	0.51
302_K	309_E	0.548	0.51
131_S	214_R	0.546	0.51
153_L	156_G	0.545	0.50
214_R	224_A	0.545	0.50
103_P	109_A	0.544	0.50
204_D	278_T	0.544	0.50
232_V	262_Y	0.543	0.50
157_E	160_N	0.541	0.50
129_A	138_E	0.540	0.50
233_Y	273_S	0.540	0.50
36_L	41_V	0.539	0.50
131_S	227_L	0.539	0.50
250_A	256_K	0.539	0.50
236_L	286_I	0.538	0.50
292_V	296_P	0.538	0.50
75_K	230_E	0.538	0.50
187_T	200_T	0.536	0.49
158_A	168_L	0.536	0.49
312_P	315_G	0.534	0.49
14_V	234_I	0.534	0.49
219_L	226_D	0.531	0.49
239_L	269_N	0.531	0.49
36_L	143_I	0.530	0.48
313_E	316_A	0.530	0.48
132_T	150_R	0.529	0.48
73_K	178_Q	0.528	0.48
52_K	196_T	0.527	0.48
224_A	272_I	0.526	0.48
136_A	140_A	0.526	0.48
154_L	160_N	0.525	0.48
30_K	137_E	0.524	0.48
295_L	300_F	0.524	0.48
27_P	182_Y	0.524	0.48
85_E	157_E	0.522	0.47
128_V	143_I	0.522	0.47
180_K	200_T	0.521	0.47
97_E	100_E	0.519	0.47
312_P	316_A	0.518	0.47
310_F	317_I	0.517	0.47
109_A	112_S	0.517	0.47
139_A	155_T	0.516	0.47
67_V	89_L	0.516	0.47
182_Y	185_L	0.515	0.47
61_E	101_E	0.514	0.46
163_P	168_L	0.513	0.46
75_K	80_F	0.513	0.46
260_L	310_F	0.511	0.46
51_I	199_F	0.511	0.46
137_E	227_L	0.511	0.46
234_I	273_S	0.511	0.46
31_Y	136_A	0.510	0.46
149_S	163_P	0.509	0.46
207_V	234_I	0.507	0.46
248_K	257_K	0.507	0.46
51_I	274_D	0.506	0.45
260_L	265_P	0.505	0.45
151_N	157_E	0.505	0.45
293_E	296_P	0.503	0.45
18_A	195_Q	0.503	0.45
114_K	126_I	0.503	0.45
216_S	231_P	0.502	0.45
141_K	148_E	0.502	0.45
148_E	155_T	0.501	0.45
240_E	266_G	0.501	0.45
131_S	162_P	0.500	0.45
240_E	244_A	0.500	0.45

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1r48A	2	0.1038	12.1	0.968	Contact Map
1cbyA	2	0.1918	11.2	0.968	Contact Map
3ronA	1	0.1698	10.7	0.968	Contact Map
2bzbA	2	0.195	6.9	0.971	Contact Map
3mceA	2	0.1761	5.9	0.972	Contact Map
2qmeI	1	0.0755	5.6	0.972	Contact Map
4hw6A	3	0.3491	5.5	0.972	Contact Map
2c0sA	1	0.2013	5.2	0.973	Contact Map
2ov2I	1	0.0755	4.9	0.973	Contact Map
1f3mA	2	0.0629	4.7	0.973	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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