GREMLIN Database
DUF4830 - Domain of unknown function (DUF4830)
PFAM: PF16112 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 84 (84)
Sequences: 1129 (906)
Seq/√Len: 98.9
META: 0.891

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
2_L70_A4.7691.00
10_D57_E3.3241.00
46_Y80_I2.6361.00
17_Q53_R2.5281.00
18_E50_R2.3541.00
16_V52_K2.1201.00
1_F41_F2.0631.00
18_E52_K2.0091.00
33_N42_D1.9481.00
51_V80_I1.9461.00
55_T71_N1.9361.00
56_Y72_L1.9361.00
3_E8_E1.8521.00
33_N37_K1.7301.00
27_E30_E1.5941.00
25_F47_A1.5701.00
15_E53_R1.5271.00
34_E37_K1.5191.00
31_E35_L1.4581.00
71_N83_D1.4351.00
49_K75_Y1.4271.00
54_Y74_V1.2950.99
37_K44_S1.2830.99
36_Q39_Q1.2810.99
9_V58_V1.2420.99
21_I51_V1.2250.99
10_D59_T1.2150.99
4_S79_V1.1920.98
21_I29_Y1.1800.98
5_Y82_G1.1750.98
35_L38_A1.1600.98
53_R71_N1.1600.98
30_E34_E1.1440.98
1_F5_Y1.1430.98
53_R73_L1.1130.97
1_F4_S1.1060.97
7_W39_Q1.0830.97
34_E38_A1.0630.97
44_S47_A1.0470.96
32_Y36_Q1.0450.96
51_V81_G1.0420.96
46_Y75_Y1.0350.96
30_E44_S1.0220.96
36_Q83_D1.0150.96
58_V70_A1.0110.96
31_E34_E0.9740.95
21_I47_A0.9710.94
23_E49_K0.9380.93
29_Y43_L0.9370.93
36_Q54_Y0.9340.93
74_V79_V0.9230.93
42_D45_K0.9170.93
23_E45_K0.9070.92
22_P25_F0.9000.92
51_V75_Y0.8890.91
8_E60_N0.8790.91
29_Y73_L0.8680.90
39_Q45_K0.8660.90
19_V28_V0.8350.89
16_V50_R0.8220.88
5_Y70_A0.8160.88
20_T50_R0.8040.87
25_F28_V0.7970.86
36_Q43_L0.7880.86
2_L82_G0.7850.85
8_E24_E0.7830.85
49_K76_K0.7770.85
45_K76_K0.7650.84
33_N83_D0.7590.83
39_Q83_D0.7430.82
20_T23_E0.7360.82
64_G67_G0.7330.81
33_N43_L0.7310.81
9_V12_E0.7300.81
75_Y80_I0.7220.80
61_Y68_V0.7050.79
25_F29_Y0.6990.78
79_V82_G0.6970.78
3_E11_P0.6940.78
16_V29_Y0.6900.77
14_I57_E0.6870.77
52_K77_G0.6860.77
10_D14_I0.6800.76
4_S41_F0.6680.75
7_W60_N0.6630.74
13_P71_N0.6630.74
19_V73_L0.6630.74
10_D13_P0.6580.74
26_D49_K0.6380.72
57_E84_I0.6310.71
28_V33_N0.6280.70
72_L79_V0.6100.68
29_Y71_N0.6040.67
7_W61_Y0.6020.67
16_V68_V0.5990.67
22_P48_G0.5910.66
18_E42_D0.5850.65
8_E59_T0.5830.65
17_Q37_K0.5800.64
20_T52_K0.5790.64
60_N68_V0.5770.64
28_V31_E0.5730.63
2_L55_T0.5720.63
32_Y83_D0.5690.63
32_Y35_L0.5610.62
27_E31_E0.5600.62
45_K75_Y0.5590.61
7_W70_A0.5460.60
30_E37_K0.5440.59
51_V64_G0.5390.59
20_T46_Y0.5390.59
50_R73_L0.5370.58
2_L29_Y0.5360.58
24_E41_F0.5360.58
21_I25_F0.5290.57
71_N81_G0.5270.57
48_G67_G0.5270.57
19_V50_R0.5210.56
9_V40_G0.5190.56
65_E76_K0.5170.56
18_E28_V0.5150.55
49_K81_G0.5100.55
3_E10_D0.5070.54
34_E78_K0.5050.54
37_K42_D0.5010.53
71_N75_Y0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1winA 1 0.4524 17 0.871 Contact Map
4anrA 1 0.8095 10.3 0.883 Contact Map
4fvgA 2 0.2619 9.4 0.885 Contact Map
4p78C 1 0.5238 7.7 0.889 Contact Map
3frmA 3 0.881 5.9 0.895 Contact Map
3ubrA 2 0.7024 5.2 0.898 Contact Map
1rz4A 2 0.4881 4.7 0.9 Contact Map
3uxjA 2 0.9405 4.6 0.9 Contact Map
5c8tB 1 0.381 4.5 0.901 Contact Map
3wdgB 1 0.7857 4.5 0.901 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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