GREMLIN Database
DUF4826 - Domain of unknown function (DUF4826)
PFAM: PF16108 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 128 (125)
Sequences: 597 (501)
Seq/√Len: 44.8
META: 0.869

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_Q14_K4.3591.00
42_A60_S4.0191.00
43_I80_L3.1691.00
68_V82_H2.5021.00
32_W36_H2.4681.00
95_L112_A2.4241.00
103_T106_E2.3511.00
80_L118_L2.3501.00
89_L93_R2.2031.00
48_S56_W2.1971.00
16_V29_V2.0650.99
92_E112_A2.0560.99
73_A82_H1.8790.99
94_L104_Q1.8560.99
24_V28_R1.8530.99
82_H86_R1.8290.99
6_A10_E1.7710.98
86_R90_K1.7700.98
110_L114_R1.7360.98
11_Q42_A1.6970.98
17_K21_E1.6280.97
45_A54_V1.5940.97
56_W69_S1.5420.96
15_A60_S1.5310.96
95_L108_A1.5210.96
34_A76_P1.5070.95
93_R96_R1.5020.95
78_E81_R1.4140.93
83_F91_A1.3960.93
70_A73_A1.3950.93
88_Q115_A1.3230.91
107_L114_R1.3230.91
45_A48_S1.3220.91
109_P113_S1.3220.91
83_F119_Y1.3210.91
35_W39_P1.3000.90
15_A22_Q1.2760.89
36_H39_P1.2440.88
88_Q119_Y1.2420.88
30_G34_A1.2060.87
19_L22_Q1.2030.86
117_L121_L1.2010.86
16_V20_A1.1960.86
48_S54_V1.1910.86
85_L88_Q1.1640.84
93_R100_H1.1610.84
28_R58_V1.1540.84
99_A103_T1.1500.84
119_Y123_E1.1210.82
75_H78_E1.1120.82
18_Y67_Y1.1020.81
96_R100_H1.1020.81
62_D114_R1.0760.79
90_K93_R1.0660.79
59_I83_F1.0630.79
88_Q116_E1.0620.79
85_L89_L1.0510.78
92_E96_R1.0440.77
11_Q60_S1.0390.77
51_P62_D1.0340.77
41_V103_T1.0320.77
44_W58_V1.0320.77
68_V83_F1.0310.76
61_G64_P1.0250.76
94_L97_G1.0240.76
15_A58_V1.0210.76
48_S55_G1.0000.74
74_K78_E0.9920.74
60_S65_T0.9890.73
30_G55_G0.9820.73
59_I118_L0.9680.72
44_W47_E0.9530.71
53_W74_K0.9400.70
72_V82_H0.9390.69
23_G43_I0.9370.69
120_E126_E0.9340.69
32_W75_H0.9260.68
42_A63_L0.9160.68
31_E34_A0.9080.67
28_R52_G0.8960.66
31_E39_P0.8940.66
24_V48_S0.8890.65
36_H63_L0.8760.64
14_K21_E0.8750.64
68_V122_A0.8730.64
12_R16_V0.8720.64
73_A119_Y0.8680.63
93_R116_E0.8500.62
69_S74_K0.8440.61
29_V63_L0.8430.61
113_S121_L0.8380.61
49_K85_L0.8350.60
33_P36_H0.8340.60
72_V84_A0.8290.60
13_Q16_V0.8290.60
46_I97_G0.8230.59
120_E123_E0.8000.57
40_Y84_A0.7960.57
64_P114_R0.7900.56
41_V63_L0.7760.55
73_A91_A0.7750.55
112_A116_E0.7730.54
48_S51_P0.7720.54
12_R29_V0.7700.54
8_C32_W0.7650.54
18_Y65_T0.7620.53
16_V31_E0.7590.53
46_I60_S0.7500.52
5_E32_W0.7490.52
30_G76_P0.7460.52
68_V72_V0.7420.51
77_R125_D0.7280.50
42_A114_R0.7160.49
47_E55_G0.7140.49
22_Q67_Y0.7070.48
42_A58_V0.7060.48
78_E115_A0.7040.48
47_E76_P0.7010.47
125_D128_W0.7000.47
115_A119_Y0.6990.47
54_V69_S0.6980.47
39_P44_W0.6950.47
66_D86_R0.6890.46
30_G45_A0.6720.45
41_V91_A0.6720.45
92_E121_L0.6710.45
120_E127_L0.6700.44
105_P115_A0.6680.44
84_A119_Y0.6670.44
90_K100_H0.6600.43
114_R118_L0.6550.43
19_L24_V0.6550.43
11_Q40_Y0.6500.43
19_L108_A0.6480.42
26_H63_L0.6450.42
63_L117_L0.6440.42
99_A104_Q0.6360.41
39_P80_L0.6350.41
5_E8_C0.6300.41
78_E91_A0.6280.40
23_G89_L0.6220.40
95_L98_E0.6200.40
73_A85_L0.6180.40
92_E95_L0.6170.39
59_I120_E0.6160.39
43_I79_A0.6130.39
15_A35_W0.6130.39
88_Q112_A0.6120.39
47_E53_W0.6040.38
96_R127_L0.6010.38
58_V116_E0.6010.38
92_E116_E0.5960.37
68_V77_R0.5960.37
72_V83_F0.5910.37
73_A78_E0.5860.37
42_A45_A0.5850.37
107_L110_L0.5830.36
70_A82_H0.5810.36
59_I70_A0.5800.36
81_R123_E0.5770.36
9_R21_E0.5740.36
116_E121_L0.5720.35
101_D106_E0.5680.35
85_L93_R0.5640.35
85_L119_Y0.5610.34
16_V25_V0.5600.34
50_D81_R0.5580.34
26_H56_W0.5560.34
10_E13_Q0.5520.34
34_A39_P0.5460.33
25_V46_I0.5450.33
28_R47_E0.5430.33
38_A41_V0.5420.33
80_L115_A0.5420.33
68_V86_R0.5400.33
72_V106_E0.5340.32
86_R116_E0.5310.32
35_W41_V0.5290.32
8_C36_H0.5270.31
46_I56_W0.5240.31
62_D113_S0.5160.31
33_P45_A0.5150.30
6_A99_A0.5090.30
53_W68_V0.5080.30
21_E99_A0.5080.30
54_V74_K0.5030.29
18_Y44_W0.5020.29
93_R121_L0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5a2tA 12 0.8359 8.1 0.943 Contact Map
2y4iB 1 0.8828 6.3 0.946 Contact Map
4azsA 6 0.7891 6 0.946 Contact Map
4doxA 1 0.8594 6 0.946 Contact Map
3ksxA 1 0.2969 5.5 0.947 Contact Map
2mpkA 1 0.4766 5.4 0.947 Contact Map
2yj1B 1 0.1172 5.3 0.948 Contact Map
2b9wA 1 0.6562 5 0.948 Contact Map
4lv5A 1 0.9297 5 0.948 Contact Map
4y85A 1 0.9062 4.3 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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