GREMLIN Database
DUF4825 - Domain of unknown function (DUF4825)
PFAM: PF16107 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 99 (88)
Sequences: 1034 (833)
Seq/√Len: 88.8
META: 0.707

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_G33_I3.6851.00
43_G80_E3.4871.00
7_P76_D3.1281.00
6_T15_V2.7691.00
40_E79_D2.6251.00
72_F78_L2.1811.00
19_I71_L2.1511.00
6_T14_A2.0441.00
68_A83_F2.0071.00
23_P48_Y1.9991.00
37_T41_P1.9461.00
36_Q45_T1.8581.00
32_G47_N1.6791.00
12_N15_V1.6561.00
35_L41_P1.6501.00
9_V44_L1.6331.00
10_G77_N1.6281.00
9_V78_L1.6141.00
78_L81_V1.5761.00
34_E45_T1.5661.00
44_L71_L1.5471.00
19_I46_V1.4370.99
4_Y21_A1.4210.99
4_Y17_N1.3950.99
66_Y70_L1.3830.99
64_F85_F1.3780.99
47_N84_N1.3510.99
43_G82_T1.3340.99
36_Q79_D1.3300.99
33_I44_L1.2750.99
71_L78_L1.2570.98
24_L48_Y1.2260.98
4_Y14_A1.2240.98
14_A17_N1.2190.98
11_D14_A1.2110.98
15_V75_I1.1270.97
41_P79_D1.1250.97
65_L69_I1.1130.96
37_T79_D1.0980.96
6_T18_I1.0850.96
44_L78_L1.0830.96
12_N33_I1.0700.96
12_N16_G1.0400.95
45_T82_T1.0190.94
18_I75_I1.0120.94
10_G35_L0.9880.93
64_F83_F0.9860.93
70_L73_A0.9500.92
34_E47_N0.9360.91
31_Y49_E0.9180.90
28_L85_F0.9130.90
19_I33_I0.8810.89
52_D56_N0.8760.88
17_N20_N0.8660.88
35_L77_N0.8630.88
59_E76_D0.8420.86
9_V43_G0.8380.86
49_E86_T0.8380.86
57_E61_E0.8250.85
64_F81_V0.8200.85
19_I44_L0.8090.84
16_G20_N0.8040.84
16_G32_G0.8020.83
51_T58_E0.7710.81
16_G19_I0.7600.80
7_P11_D0.7560.80
53_E62_E0.7510.79
34_E37_T0.7420.78
10_G13_S0.7380.78
53_E56_N0.7310.77
15_V44_L0.7260.77
37_T42_Y0.7210.76
37_T45_T0.7180.76
35_L40_E0.7170.76
8_Y77_N0.7160.76
14_A18_I0.7020.74
7_P32_G0.7010.74
17_N21_A0.6990.74
9_V37_T0.6980.74
61_E82_T0.6930.73
69_I73_A0.6910.73
66_Y75_I0.6830.72
36_Q80_E0.6690.71
3_K13_S0.6670.71
1_L4_Y0.6630.70
5_K55_I0.6550.69
45_T84_N0.6500.69
71_L75_I0.6450.68
1_L74_L0.6410.68
42_Y79_D0.6390.67
26_E50_T0.6380.67
3_K59_E0.6380.67
30_Y72_F0.6360.67
23_P66_Y0.6260.66
23_P67_N0.6200.65
9_V15_V0.6150.64
62_E88_D0.6010.63
6_T76_D0.6000.63
12_N77_N0.5990.62
31_Y46_V0.5970.62
44_L75_I0.5920.61
7_P24_L0.5810.60
3_K57_E0.5810.60
40_E43_G0.5800.60
15_V33_I0.5790.60
54_S58_E0.5770.60
32_G48_Y0.5730.59
54_S87_D0.5640.58
42_Y78_L0.5630.58
5_K79_D0.5610.57
71_L81_V0.5600.57
57_E60_L0.5570.57
18_I21_A0.5540.56
19_I83_F0.5530.56
4_Y72_F0.5490.56
24_L72_F0.5460.55
25_P50_T0.5460.55
9_V71_L0.5430.55
26_E59_E0.5420.55
24_L51_T0.5390.54
7_P18_I0.5380.54
4_Y18_I0.5380.54
16_G46_V0.5350.54
44_L81_V0.5260.53
18_I23_P0.5230.52
20_N46_V0.5210.52
3_K58_E0.5200.52
29_G40_E0.5170.51
67_N74_L0.5110.51
55_I66_Y0.5110.51
14_A73_A0.5090.50
29_G69_I0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3enuA 2 0.3636 5.2 0.916 Contact Map
3r2nA 4 0.2424 2.9 0.926 Contact Map
3htnA 3 0.6768 2.9 0.926 Contact Map
1zxhA 1 0.4949 2.6 0.927 Contact Map
1l8nA 2 1 2.6 0.928 Contact Map
1pn5A 1 0.0101 2.5 0.928 Contact Map
2z16A 1 0.7071 2.4 0.929 Contact Map
4qeyA 3 0.8384 2.4 0.929 Contact Map
3hwuA 3 0.697 2.2 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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