GREMLIN Database
Phage_holin_2_3 - Bacteriophage holin family HP1
PFAM: PF16080 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 55 (52)
Sequences: 822 (629)
Seq/√Len: 87.2
META: 0.616

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_E53_L4.0111.00
46_K49_E3.4921.00
41_V45_Y2.1191.00
47_R51_K1.8601.00
11_G38_T1.8061.00
8_S38_T1.7451.00
5_S42_N1.7231.00
48_K52_L1.6711.00
27_A32_I1.5891.00
38_T42_N1.5081.00
9_Y38_T1.4860.99
23_L26_W1.4550.99
34_I39_F1.4320.99
15_T31_G1.4040.99
6_A10_G1.3800.99
9_Y12_S1.3590.99
7_A10_G1.2980.99
26_W29_I1.2890.99
11_G15_T1.2440.98
23_L32_I1.2350.98
15_T35_G1.2330.98
48_K51_K1.1690.97
19_G31_G1.1070.96
49_E52_L1.0890.96
30_V36_V1.0650.95
43_W47_R1.0440.95
4_T8_S1.0400.95
11_G14_A1.0270.94
29_I33_V1.0020.93
30_V33_V0.9950.93
2_K6_A0.9670.92
9_Y42_N0.9640.92
19_G27_A0.9560.92
28_A32_I0.9430.91
23_L27_A0.9400.91
12_S15_T0.8880.88
39_F43_W0.8840.88
3_I6_A0.8480.86
17_L21_L0.7960.82
30_V34_I0.7860.82
44_Y48_K0.7730.80
44_Y49_E0.7710.80
46_K50_Y0.7520.79
10_G17_L0.7470.78
21_L24_N0.7440.78
23_L29_I0.7250.76
14_A40_L0.7200.76
12_S31_G0.7060.74
13_G40_L0.6910.73
15_T27_A0.6870.72
33_V47_R0.6670.70
19_G30_V0.6410.67
14_A51_K0.6340.66
10_G51_K0.6340.66
33_V43_W0.6330.66
28_A35_G0.6300.66
25_E28_A0.6230.65
16_A51_K0.6220.65
11_G18_F0.6170.64
12_S34_I0.5800.59
7_A37_A0.5790.59
10_G19_G0.5780.59
40_L44_Y0.5700.58
15_T24_N0.5680.58
15_T40_L0.5590.56
17_L25_E0.5530.56
3_I13_G0.5300.53
26_W30_V0.5270.52
13_G33_V0.5240.52
22_T29_I0.5210.51
20_A23_L0.5180.51
15_T28_A0.5160.51
17_L20_A0.5050.49
4_T10_G0.5040.49
50_Y53_L0.5020.49
23_L33_V0.5010.49
15_T25_E0.5000.48
12_S35_G0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kluA 1 0.6364 29.8 0.812 Contact Map
2l2tA 2 0.7818 25 0.819 Contact Map
4ry2A 2 1 24.6 0.82 Contact Map
4a82A 2 1 23.1 0.822 Contact Map
4q4hB 1 1 22.7 0.823 Contact Map
4um9B 2 0 22.3 0.823 Contact Map
4f4cA 1 1 21.6 0.825 Contact Map
3b5xA 2 1 17.4 0.832 Contact Map
2m20A 2 0.6545 16.5 0.834 Contact Map
4tllA 1 0.5818 15.7 0.835 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0038 seconds.