GREMLIN Database
Acyltransf_C - Acyltransferase C-terminus
PFAM: PF16076 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 76 (72)
Sequences: 963 (665)
Seq/√Len: 78.4
META: 0.221

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_E51_T3.6581.00
12_H48_F3.2771.00
16_R40_E2.7401.00
26_D29_E2.5931.00
32_Q36_D2.3921.00
46_E50_E2.2051.00
23_I30_L2.1481.00
24_P33_W2.1471.00
37_R40_E2.0641.00
14_H44_L2.0371.00
36_D39_Q1.9081.00
47_E55_P1.8351.00
36_D40_E1.4450.99
45_L49_Y1.4240.99
39_Q43_A1.4220.99
66_R69_S1.4210.99
11_V45_L1.3520.98
20_I23_I1.3380.98
23_I33_W1.3320.98
35_H39_Q1.2940.98
43_A47_E1.2510.97
18_I37_R1.2490.97
7_K38_F1.2040.97
65_R68_K1.1980.97
31_A35_H1.1660.96
5_N16_R1.1640.96
7_K13_V1.1220.95
19_P22_D1.1060.95
29_E32_Q1.0920.94
42_D46_E1.0790.94
38_F42_D1.0550.93
34_L41_K1.0280.92
71_L74_L1.0100.92
35_H38_F0.9700.90
59_E62_E0.9590.90
60_E63_L0.9230.88
67_P70_L0.9190.87
28_E39_Q0.8980.86
33_W45_L0.8890.86
42_D49_Y0.8850.85
13_V42_D0.8830.85
69_S72_N0.8800.85
11_V15_V0.8770.85
67_P74_L0.8620.84
37_R48_F0.8580.84
47_E53_T0.8570.84
28_E31_A0.8310.82
8_P38_F0.8290.81
30_L38_F0.8230.81
30_L45_L0.8220.81
65_R69_S0.8010.79
32_Q35_H0.7990.79
58_G63_L0.7940.79
42_D52_G0.7890.78
18_I23_I0.7810.77
44_L55_P0.7650.76
8_P13_V0.7620.76
57_P60_E0.7510.75
18_I40_E0.7390.73
22_D29_E0.7380.73
53_T57_P0.7360.73
48_F53_T0.7320.73
23_I26_D0.7310.73
7_K42_D0.7210.72
13_V38_F0.7200.71
11_V14_H0.7200.71
53_T61_V0.7140.71
52_G55_P0.7070.70
44_L52_G0.7060.70
68_K73_F0.7060.70
34_L62_E0.7030.70
17_R24_P0.7030.70
32_Q39_Q0.6960.69
67_P73_F0.6950.69
68_K74_L0.6900.68
15_V49_Y0.6870.68
46_E51_T0.6830.67
34_L44_L0.6810.67
19_P38_F0.6800.67
15_V25_E0.6650.65
8_P11_V0.6550.64
7_K10_E0.6550.64
17_R20_I0.6520.64
65_R72_N0.6460.63
8_P45_L0.6460.63
19_P25_E0.6460.63
16_R24_P0.6410.63
25_E30_L0.6380.62
65_R70_L0.6340.62
51_T58_G0.6290.61
21_K29_E0.6220.60
17_R65_R0.6210.60
9_S15_V0.6210.60
7_K15_V0.6150.59
22_D25_E0.6050.58
9_S12_H0.5970.57
42_D55_P0.5970.57
9_S42_D0.5650.53
40_E71_L0.5620.53
21_K25_E0.5520.51
68_K71_L0.5260.48
69_S73_F0.5220.48
59_E63_L0.5170.47
21_K64_P0.5080.46
3_L7_K0.5070.46
42_D54_F0.5040.45
16_R21_K0.5030.45
53_T56_A0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pt1A 1 0.8684 14.1 0.881 Contact Map
3ts9A 1 0.6711 7.1 0.896 Contact Map
2ellA 1 0.3816 6.2 0.899 Contact Map
3it3A 2 0.8816 5.2 0.902 Contact Map
3tbiA 1 0.4079 4.8 0.904 Contact Map
3fs8A 3 0.4868 4.5 0.905 Contact Map
3k93A 3 0.5789 4 0.908 Contact Map
2jttC 1 0.3421 2.8 0.915 Contact Map
2q83A 1 0.6316 2.7 0.915 Contact Map
3exaA 2 0.5526 2.5 0.917 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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