GREMLIN Database
PilW - Type IV Pilus-assembly protein W
PFAM: PF16074 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 127 (120)
Sequences: 10988 (9149)
Seq/√Len: 835.2
META: 0.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_V84_A3.8241.00
85_R114_Y3.0511.00
39_E116_R3.0491.00
46_G77_A2.4531.00
14_T33_P2.3961.00
44_L79_R2.3891.00
5_A16_Y2.3601.00
39_E85_R2.1501.00
37_G87_T2.1361.00
7_D10_G2.0271.00
18_K31_A2.0081.00
16_Y33_P1.9331.00
48_D56_D1.9071.00
81_A118_V1.9011.00
55_V76_V1.8551.00
52_D56_D1.7781.00
47_V59_V1.7531.00
80_V123_V1.7501.00
81_A101_L1.6671.00
81_A102_G1.6101.00
44_L81_A1.6071.00
41_L82_L1.5991.00
16_Y31_A1.5951.00
60_T63_A1.5641.00
17_R32_Q1.5621.00
43_V80_V1.5571.00
81_A120_T1.5471.00
58_Y77_A1.4991.00
72_W75_V1.4961.00
84_A119_F1.4881.00
90_D93_Y1.4061.00
2_Y17_R1.4041.00
45_Y61_A1.3921.00
89_P113_R1.3761.00
90_D115_R1.3281.00
106_V109_A1.3241.00
99_Y102_G1.3221.00
83_L118_V1.3211.00
43_V78_V1.2991.00
48_D52_D1.2911.00
46_G58_Y1.2711.00
13_P85_R1.2701.00
12_I37_G1.2581.00
7_D33_P1.2461.00
3_Y31_A1.2451.00
59_V63_A1.2381.00
77_A122_T1.2071.00
44_L60_T1.2021.00
19_E32_Q1.1851.00
107_T110_N1.1811.00
100_T103_G1.1811.00
71_D74_R1.1591.00
100_T105_T1.1481.00
20_L24_G1.1241.00
24_G27_G1.1151.00
65_T69_A1.1111.00
79_R122_T1.1041.00
101_L104_A1.1011.00
47_V74_R1.0661.00
95_D99_Y1.0441.00
66_A69_A1.0201.00
89_P93_Y1.0201.00
7_D16_Y1.0161.00
6_N9_D0.9981.00
6_N10_G0.9881.00
3_Y18_K0.9861.00
50_D56_D0.9821.00
18_K29_G0.9511.00
63_A66_A0.9461.00
5_A31_A0.9221.00
64_V70_A0.9181.00
108_P111_D0.9061.00
45_Y75_V0.9011.00
40_D106_V0.9001.00
107_T111_D0.8881.00
45_Y78_V0.8551.00
92_G113_R0.8521.00
17_R20_L0.8421.00
9_D12_I0.8421.00
47_V57_R0.8371.00
59_V71_D0.8361.00
36_E87_T0.8321.00
83_L101_L0.8261.00
78_V81_A0.8251.00
101_L118_V0.8231.00
48_D76_V0.8221.00
89_P114_Y0.8211.00
79_R120_T0.8151.00
44_L103_G0.8141.00
48_D53_G0.8061.00
47_V75_V0.8021.00
98_T101_L0.8001.00
98_T105_T0.7951.00
7_D12_I0.7881.00
14_T36_E0.7831.00
42_Q81_A0.7771.00
62_D65_T0.7731.00
49_T57_R0.7701.00
64_V67_A0.7671.00
46_G55_V0.7671.00
24_G28_A0.7651.00
99_Y103_G0.7541.00
89_P92_G0.7501.00
27_G31_A0.7431.00
100_T104_A0.7331.00
4_V41_L0.7321.00
80_V121_T0.7271.00
103_G106_V0.7221.00
96_T99_Y0.7171.00
62_D66_A0.7121.00
40_D101_L0.7121.00
58_Y79_R0.7041.00
44_L102_G0.7011.00
120_T124_A0.6971.00
93_Y97_K0.6951.00
3_Y16_Y0.6951.00
94_T113_R0.6851.00
55_V77_A0.6791.00
12_I36_E0.6791.00
102_G106_V0.6741.00
9_D36_E0.6671.00
13_P17_R0.6641.00
41_L80_V0.6621.00
12_I114_Y0.6611.00
100_T106_V0.6591.00
51_G74_R0.6541.00
33_P36_E0.6541.00
20_L25_G0.6441.00
58_Y61_A0.6431.00
7_D14_T0.6431.00
49_T56_D0.6311.00
53_G56_D0.6201.00
18_K30_T0.6131.00
12_I85_R0.6121.00
83_L99_Y0.6111.00
40_D83_L0.6111.00
63_A67_A0.6091.00
61_A65_T0.6071.00
39_E83_L0.6051.00
48_D55_V0.6021.00
95_D98_T0.6021.00
117_R124_A0.6001.00
14_T17_R0.6001.00
102_G105_T0.5971.00
5_A10_G0.5961.00
59_V62_D0.5951.00
20_L29_G0.5951.00
64_V69_A0.5941.00
86_S115_R0.5831.00
94_T98_T0.5831.00
97_K101_L0.5821.00
47_V70_A0.5761.00
57_R71_D0.5691.00
61_A64_V0.5691.00
98_T102_G0.5681.00
62_D67_A0.5651.00
91_P94_T0.5631.00
78_V125_L0.5611.00
43_V116_R0.5551.00
106_V110_N0.5491.00
47_V71_D0.5461.00
46_G79_R0.5461.00
28_A31_A0.5421.00
35_V38_V0.5361.00
6_N12_I0.5331.00
39_E43_V0.5321.00
52_D55_V0.5251.00
49_T52_D0.5251.00
115_R118_V0.5231.00
79_R117_R0.5181.00
82_L119_F0.5171.00
93_Y96_T0.5141.00
65_T70_A0.5121.00
57_R61_A0.5101.00
59_V64_V0.5101.00
42_Q103_G0.5091.00
85_R116_R0.5041.00
24_G29_G0.5031.00
65_T71_D0.5021.00
90_D113_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2retB 2 0.6457 63.3 0.846 Contact Map
3ci0J 1 0.6299 49.9 0.858 Contact Map
3njeA 1 0.7323 30.4 0.874 Contact Map
4ov8A 1 0.9291 7.1 0.906 Contact Map
4kyzA 1 0.6299 2.7 0.923 Contact Map
3weuA 4 0.0709 2.1 0.928 Contact Map
4tx1A 5 0.252 2 0.929 Contact Map
4jutA 4 0.5197 1.9 0.929 Contact Map
4phqA 1 0.3386 1.1 0.939 Contact Map
3w3sA 2 0.6299 1 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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