GREMLIN Database
DUF4806 - Domain of unknown function (DUF4806)
PFAM: PF16064 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 88 (77)
Sequences: 606 (563)
Seq/√Len: 64.1
META: 0.031

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_E62_Y3.1281.00
12_E73_K2.7871.00
29_R33_V2.6371.00
56_D59_A2.4951.00
75_F78_L2.3971.00
21_K28_F2.2701.00
11_T14_D2.2621.00
54_F59_A2.2261.00
10_K55_T2.1221.00
62_Y73_K2.1141.00
63_S68_K2.0831.00
9_L18_L2.0641.00
9_L58_L2.0501.00
15_L78_L1.7961.00
10_K57_E1.7931.00
72_K75_F1.7881.00
15_L58_L1.7461.00
64_W82_C1.6590.99
74_A77_N1.5350.99
13_E17_E1.5240.99
9_L15_L1.4560.98
28_F32_L1.4470.98
36_L53_L1.3900.97
26_E57_E1.3560.97
66_G72_K1.3200.97
76_K81_F1.3000.96
63_S74_A1.2810.96
54_F58_L1.2200.95
59_A64_W1.1820.94
51_K56_D1.1790.94
14_D26_E1.1620.93
11_T15_L1.1370.92
44_N52_K1.1080.91
14_D17_E1.0850.90
55_T58_L1.0190.87
33_V37_S1.0130.87
54_F81_F0.9730.85
9_L19_E0.9710.85
46_V56_D0.9610.84
22_L32_L0.9500.83
65_T76_K0.9460.83
17_E21_K0.9040.80
16_E51_K0.8860.79
13_E26_E0.8840.79
41_G48_R0.8780.78
13_E24_N0.8730.78
63_S66_G0.8670.77
62_Y78_L0.8500.76
16_E78_L0.8500.76
27_E32_L0.8450.76
55_T67_R0.8220.74
7_F69_G0.8180.73
65_T69_G0.8000.72
18_L22_L0.7930.71
45_S50_L0.7900.71
17_E25_D0.7730.69
25_D64_W0.7670.68
22_L61_K0.7660.68
7_F46_V0.7600.68
49_I63_S0.7440.66
36_L74_A0.7400.66
44_N48_R0.7170.63
26_E74_A0.7100.62
34_K60_S0.7060.62
64_W67_R0.6800.59
63_S69_G0.6740.58
22_L52_K0.6720.58
18_L25_D0.6610.57
11_T18_L0.6580.56
20_E24_N0.6540.56
45_S49_I0.6520.56
47_R63_S0.6490.55
16_E25_D0.6480.55
62_Y68_K0.6480.55
47_R50_L0.6460.55
44_N67_R0.6440.55
78_L81_F0.6380.54
19_E33_V0.6340.54
35_Y62_Y0.6320.54
10_K13_E0.6300.53
15_L54_F0.6290.53
64_W75_F0.6210.52
19_E65_T0.6180.52
7_F51_K0.6140.51
33_V60_S0.6120.51
48_R67_R0.6070.51
21_K33_V0.6020.50
43_K47_R0.5970.49
12_E53_L0.5870.48
21_K32_L0.5810.48
23_K79_K0.5790.47
17_E20_E0.5780.47
61_K84_V0.5770.47
12_E72_K0.5770.47
39_I46_V0.5760.47
10_K14_D0.5660.46
36_L49_I0.5650.46
53_L75_F0.5610.45
28_F63_S0.5600.45
64_W69_G0.5560.45
56_D63_S0.5500.44
82_C85_I0.5490.44
35_Y79_K0.5390.43
77_N84_V0.5340.42
24_N63_S0.5270.41
14_D51_K0.5260.41
39_I48_R0.5230.41
44_N83_K0.5220.41
29_R54_F0.5180.40
22_L58_L0.5170.40
15_L68_K0.5140.40
33_V38_R0.5070.39
46_V49_I0.5070.39
12_E61_K0.5050.39
47_R51_K0.5040.39
21_K58_L0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ux8A 4 0.4659 21.3 0.862 Contact Map
3wvzA 2 0.3409 13.5 0.874 Contact Map
1u7lA 1 0.9432 11.5 0.878 Contact Map
4ix7A 1 0.8182 8.7 0.884 Contact Map
2e3dA 3 0.4545 7.4 0.889 Contact Map
3sxxA 5 0.8636 7.2 0.889 Contact Map
2fclA 1 0.3864 7.1 0.889 Contact Map
3ja82 1 0.8977 6.7 0.89 Contact Map
3i5qB 4 0.8636 5.3 0.895 Contact Map
1twfA 1 0.9886 5.2 0.896 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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