GREMLIN Database
Mucin-like - Mucin-like
PFAM: PF16058 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 100 (93)
Sequences: 1161 (975)
Seq/√Len: 101.1
META: 0.416

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_L77_L2.3191.00
33_L55_L2.2331.00
44_L66_L2.1691.00
22_L44_L2.1191.00
23_A45_T1.8851.00
56_T67_T1.8041.00
48_S70_S1.7921.00
22_L66_L1.7441.00
59_S81_S1.7371.00
56_T78_A1.7201.00
44_L88_Q1.7141.00
34_T56_T1.7061.00
36_S58_S1.6431.00
58_S80_S1.6291.00
37_S59_S1.5821.00
45_T67_T1.5721.00
32_S65_P1.5221.00
26_S59_S1.4571.00
39_Y61_Y1.4421.00
66_L88_Q1.4381.00
54_P76_P1.4031.00
47_S69_S1.3921.00
66_L77_L1.3760.99
21_P32_S1.3450.99
34_T78_A1.3120.99
33_L77_L1.2890.99
25_S69_S1.2710.99
15_S37_S1.2610.99
36_S80_S1.2580.99
38_S60_S1.2470.99
32_S43_P1.2420.99
23_A34_T1.2320.99
45_T78_A1.2070.99
22_L55_L1.2070.99
63_A85_A1.2060.99
57_P79_P1.1990.99
26_S37_S1.1930.99
26_S48_S1.1930.99
25_S47_S1.1680.98
15_S26_S1.1400.98
48_S81_S1.1110.98
51_G73_G1.1070.98
43_P65_P1.1060.98
44_L55_L1.1050.98
67_T78_A1.0920.97
41_A63_A1.0870.97
69_S91_S1.0760.97
32_S54_P1.0730.97
21_P43_P1.0640.97
78_A89_T1.0560.97
29_G51_G1.0550.97
67_T89_T1.0480.97
42_P64_P1.0470.97
21_P65_P1.0280.96
52_A74_A1.0270.96
37_S81_S1.0210.96
61_Y83_Y1.0210.96
22_L33_L1.0170.96
21_P54_P1.0160.96
77_L88_Q1.0130.96
33_L44_L0.9990.96
41_A85_A0.9970.96
65_P87_P0.9870.95
34_T45_T0.9800.95
54_P65_P0.9780.95
62_G84_G0.9680.95
55_L88_Q0.9660.95
64_P86_P0.9620.95
65_P76_P0.9570.94
44_L77_L0.9550.94
42_P86_P0.9530.94
55_L66_L0.9400.94
45_T56_T0.9360.94
28_Y50_Y0.9330.94
17_Y61_Y0.9070.93
23_A67_T0.9000.92
70_S81_S0.8840.92
43_P76_P0.8820.92
32_S76_P0.8790.91
43_P54_P0.8740.91
43_P87_P0.8730.91
14_S36_S0.8600.91
20_P42_P0.8460.90
53_P75_P0.8420.90
27_S49_S0.8390.89
47_S91_S0.8220.88
20_P64_P0.8110.88
60_S82_S0.7780.86
16_S38_S0.7760.85
40_G62_G0.7680.85
37_S48_S0.7660.85
19_A41_A0.7630.84
16_S60_S0.7510.84
59_S70_S0.7370.82
23_A56_T0.7300.82
34_T67_T0.7270.82
46_P68_P0.7250.81
37_S70_S0.7240.81
45_T89_T0.7210.81
29_G62_G0.7160.81
41_A52_A0.7120.80
25_S58_S0.7010.79
30_A52_A0.7010.79
15_S59_S0.6870.78
17_Y39_Y0.6820.77
28_Y61_Y0.6810.77
24_P46_P0.6750.76
36_S69_S0.6720.76
11_S22_L0.6570.75
54_P87_P0.6470.73
40_G73_G0.6460.73
18_G40_G0.6300.71
35_P79_P0.6300.71
23_A78_A0.6200.70
11_S33_L0.6190.70
25_S36_S0.6150.70
39_Y83_Y0.6100.69
58_S69_S0.6050.68
48_S59_S0.5880.66
52_A63_A0.5870.66
60_S71_S0.5860.66
33_L66_L0.5830.66
31_P75_P0.5820.65
40_G51_G0.5820.65
31_P53_P0.5800.65
42_P53_P0.5700.64
26_S70_S0.5700.64
56_T89_T0.5670.63
12_T34_T0.5660.63
29_G73_G0.5660.63
61_Y72_Y0.5640.63
25_S91_S0.5590.62
70_S92_S0.5500.61
68_P90_P0.5420.60
22_L88_Q0.5370.59
38_S82_S0.5320.59
46_P57_P0.5300.58
18_G62_G0.5150.56
76_P87_P0.5040.55
50_Y72_Y0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rcoA 1 0 0.4 0.92 Contact Map
2kvpA 1 0.34 0.3 0.925 Contact Map
2o14A 1 0.26 0.3 0.925 Contact Map
1gff1 6 0.53 0.3 0.926 Contact Map
2b0hA 1 0.34 0.3 0.926 Contact Map
1ivnA 2 0.24 0.3 0.926 Contact Map
1fxwF 1 0.22 0.3 0.926 Contact Map
1kvpA 10 0.53 0.3 0.929 Contact Map
2bpa1 10 0.53 0.3 0.929 Contact Map
2qwoB 1 0.31 0.3 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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