GREMLIN Database
DUF4782 - Domain of unknown function (DUF4782)
PFAM: PF16016 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 154 (149)
Sequences: 1609 (1233)
Seq/√Len: 101.0
META: 0.259

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_D128_R5.7121.00
38_D59_T4.4721.00
109_R138_L3.5121.00
119_A123_S3.1701.00
107_Y141_T2.9121.00
37_T70_Q2.8251.00
27_K31_E2.8161.00
146_K150_G2.8091.00
101_D105_G2.7121.00
117_T130_R2.5611.00
114_Y129_L2.4011.00
9_I14_L2.2991.00
14_L116_I2.0631.00
54_R77_Q2.0521.00
19_F114_Y2.0181.00
14_L18_L1.9991.00
133_T152_I1.8861.00
72_K101_D1.8761.00
6_V128_R1.8281.00
104_Y107_Y1.7961.00
99_P105_G1.7791.00
10_S13_K1.7741.00
106_D139_K1.7651.00
99_P102_V1.6991.00
144_K148_E1.6811.00
11_V127_C1.6731.00
44_W54_R1.6561.00
15_F79_Y1.6411.00
83_N89_Y1.6091.00
55_T74_T1.5591.00
115_C132_S1.5171.00
26_F30_L1.5091.00
59_T70_Q1.4541.00
104_Y141_T1.4541.00
112_T133_T1.4521.00
107_Y139_K1.4521.00
44_W77_Q1.4211.00
71_T102_V1.4141.00
90_Y116_I1.3981.00
143_L146_K1.3750.99
68_P71_T1.3380.99
58_Y154_G1.3260.99
33_R36_D1.3160.99
6_V119_A1.3130.99
82_E93_V1.2600.99
36_D60_K1.2590.99
102_V108_F1.2590.99
36_D75_E1.2410.99
30_L39_I1.2170.99
62_L154_G1.2020.99
3_L129_L1.1970.99
73_C101_D1.1950.99
7_F18_L1.1810.98
62_L68_P1.1770.98
6_V126_T1.1010.97
58_Y98_T1.0990.97
2_L133_T1.0890.97
11_V118_W1.0830.97
25_F29_F1.0670.97
40_S57_S1.0650.97
24_S28_K1.0640.97
21_D24_S1.0570.97
74_T96_T1.0170.96
32_E136_E1.0140.96
117_T128_R1.0070.96
74_T99_P1.0070.96
137_W147_I1.0030.96
91_L115_C0.9860.95
113_R132_S0.9850.95
143_L147_I0.9820.95
62_L65_P0.9800.95
84_D87_G0.9770.95
30_L58_Y0.9610.95
60_K71_T0.9550.94
29_F33_R0.9500.94
44_W56_V0.9470.94
111_E136_E0.9430.94
42_G55_T0.9410.94
71_T101_D0.9310.94
95_T111_E0.9310.94
7_F14_L0.9290.93
121_N128_R0.9280.93
103_P108_F0.9270.93
36_D151_A0.9260.93
65_P71_T0.9230.93
11_V116_I0.9170.93
15_F19_F0.9130.93
22_D134_G0.9050.93
11_V15_F0.9040.93
58_Y73_C0.8810.92
105_G108_F0.8720.91
26_F39_I0.8700.91
66_I104_Y0.8590.90
37_T59_T0.8570.90
149_K153_D0.8560.90
37_T61_P0.8440.90
56_V77_Q0.8380.89
104_Y139_K0.8330.89
150_G153_D0.8300.89
44_W116_I0.8270.89
120_S142_W0.8090.88
75_E114_Y0.8070.88
73_C99_P0.8020.87
120_S123_S0.7930.87
20_G23_S0.7930.87
14_L25_F0.7840.86
13_K16_E0.7820.86
3_L25_F0.7730.85
59_T72_K0.7700.85
102_V144_K0.7660.85
42_G45_K0.7650.85
41_I56_V0.7640.85
123_S126_T0.7630.84
28_K32_E0.7590.84
64_G67_G0.7550.84
82_E86_L0.7550.84
49_S74_T0.7520.84
109_R140_S0.7480.83
85_D118_W0.7400.83
93_V137_W0.7400.83
60_K154_G0.7320.82
74_T97_Q0.7290.82
53_T136_E0.7200.81
110_V150_G0.7160.80
53_T92_V0.7160.80
2_L5_E0.7160.80
30_L78_T0.7110.80
36_D77_Q0.7070.80
29_F75_E0.7050.79
64_G142_W0.6980.79
65_P68_P0.6980.79
41_I50_G0.6960.79
36_D61_P0.6950.78
47_D127_C0.6940.78
48_E51_G0.6930.78
53_T78_T0.6810.77
82_E92_V0.6800.77
35_G61_P0.6750.76
14_L129_L0.6750.76
110_V151_A0.6730.76
30_L36_D0.6720.76
53_T76_T0.6700.76
137_W148_E0.6650.75
12_E16_E0.6650.75
109_R129_L0.6650.75
3_L7_F0.6630.75
23_S44_W0.6560.74
75_E112_T0.6550.74
86_L90_Y0.6470.73
102_V110_V0.6430.73
4_D136_E0.6390.72
9_I117_T0.6380.72
19_F116_I0.6370.72
76_T109_R0.6360.72
41_I149_K0.6320.72
30_L33_R0.6250.71
119_A126_T0.6250.71
52_L116_I0.6240.71
21_D27_K0.6230.71
67_G108_F0.6220.70
19_F132_S0.6190.70
12_E116_I0.6180.70
18_L147_I0.6170.70
10_S20_G0.6170.70
95_T109_R0.6110.69
24_S103_P0.6070.69
35_G73_C0.6030.68
74_T98_T0.5970.67
18_L95_T0.5930.67
18_L23_S0.5930.67
58_Y104_Y0.5920.67
96_T111_E0.5880.66
29_F36_D0.5830.66
62_L69_K0.5820.65
51_G55_T0.5820.65
14_L19_F0.5770.65
62_L66_I0.5750.64
39_I103_P0.5750.64
14_L114_Y0.5740.64
8_P39_I0.5710.64
43_P119_A0.5710.64
24_S46_K0.5650.63
39_I71_T0.5640.63
12_E87_G0.5610.63
98_T113_R0.5570.62
109_R136_E0.5560.62
46_K53_T0.5560.62
4_D18_L0.5550.62
16_E22_D0.5520.61
33_R60_K0.5510.61
60_K63_N0.5510.61
10_S15_F0.5500.61
67_G135_V0.5470.61
135_V147_I0.5460.60
106_D135_V0.5450.60
54_R58_Y0.5450.60
67_G102_V0.5450.60
62_L71_T0.5450.60
62_L151_A0.5430.60
140_S152_I0.5410.60
47_D51_G0.5380.59
20_G101_D0.5370.59
72_K148_E0.5340.59
39_I42_G0.5330.59
57_S139_K0.5330.59
68_P103_P0.5310.58
7_F43_P0.5300.58
44_W115_C0.5280.58
47_D52_L0.5270.58
9_I16_E0.5250.58
21_D43_P0.5250.58
2_L58_Y0.5250.58
116_I127_C0.5230.57
38_D61_P0.5200.57
43_P128_R0.5140.56
83_N88_K0.5130.56
12_E84_D0.5120.56
64_G73_C0.5120.56
113_R117_T0.5050.55
90_Y93_V0.5040.55
17_L25_F0.5030.54
30_L75_E0.5030.54
7_F17_L0.5020.54
25_F110_V0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3p0lA 1 0.8831 45.7 0.89 Contact Map
4c9cA 1 0.8247 45.3 0.89 Contact Map
2qimA 1 0.8506 40.8 0.893 Contact Map
4jhgA 2 0.8442 40.3 0.893 Contact Map
1ln1A 1 0.8896 40.3 0.893 Contact Map
2wqlA 4 0.8442 39.8 0.893 Contact Map
1icxA 1 0.8506 29.6 0.9 Contact Map
4bk7A 1 0.8636 28.6 0.901 Contact Map
3qszA 1 0.8636 22.7 0.906 Contact Map
2r55A 1 0.8831 22.2 0.906 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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