GREMLIN Database
Collagen_mid - Bacterial collagen, middle region
PFAM: PF15984 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 199 (194)
Sequences: 517 (323)
Seq/√Len: 23.2
META: 0.416

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_A61_A4.2701.00
63_S92_S3.7471.00
18_S64_S3.1311.00
66_G88_G3.0871.00
179_V182_V3.0421.00
26_L54_V2.7440.99
56_S99_T2.5300.99
193_A196_L2.4700.98
117_V188_N2.4230.98
59_G95_G2.4150.98
66_G95_G2.4110.98
88_G91_V2.3940.98
65_L68_L2.3140.97
151_G154_G2.2720.97
7_Q71_S2.2010.96
22_A58_L2.1330.96
15_V68_L2.1230.95
30_V167_V2.1170.95
22_A54_V2.0980.95
52_G102_G2.0820.95
168_T184_T2.0200.94
8_T11_G1.9990.94
146_G194_G1.9920.94
161_A184_T1.9700.93
21_N57_D1.9700.93
11_G71_S1.9320.93
125_I128_V1.9250.92
142_A145_L1.8700.91
80_L86_P1.8230.90
160_V163_A1.7980.89
179_V197_V1.7550.88
34_L48_V1.7530.88
157_G187_G1.7220.87
51_V54_V1.6900.86
14_G18_S1.6750.86
87_V90_V1.6410.85
34_L53_N1.6270.84
40_N46_T1.6000.83
143_T148_P1.5490.81
10_Q36_Q1.5380.80
27_G95_G1.5290.80
31_S44_V1.5140.79
47_T118_T1.5040.79
63_S99_T1.5000.79
28_N32_N1.4640.77
50_S71_S1.4240.75
91_V95_G1.4220.75
156_V163_A1.4120.74
85_T97_A1.4000.74
94_V97_A1.3950.73
135_T139_V1.3790.73
59_G88_G1.3790.73
121_L124_A1.3670.72
90_V165_T1.3530.71
136_T143_T1.3520.71
42_N45_G1.3450.71
11_G65_L1.3430.70
80_L83_V1.3410.70
186_V197_V1.3300.70
26_L50_S1.3260.70
29_G50_S1.3180.69
82_P86_P1.3100.69
43_P82_P1.2930.68
141_T179_V1.2670.66
77_L84_T1.2060.62
143_T160_V1.1870.61
67_G101_L1.1850.61
78_A82_P1.1810.60
136_T148_P1.1740.60
43_P129_T1.1660.59
91_V132_V1.1600.59
167_V183_V1.1600.59
97_A101_L1.1580.59
56_S160_V1.1500.58
30_V169_G1.1480.58
42_N46_T1.1470.58
27_G66_G1.1440.58
173_N176_T1.1220.56
20_G59_G1.1120.56
149_V152_L1.0870.54
114_V129_T1.0860.54
114_V128_V1.0850.54
69_V72_L1.0660.52
106_G109_L1.0620.52
21_N25_T1.0590.52
69_V73_G1.0570.52
62_V98_V1.0570.52
130_S179_V1.0460.51
25_T57_D1.0390.51
55_V118_T1.0220.49
26_L29_G1.0220.49
140_G146_G1.0130.49
36_Q39_T1.0130.49
171_T176_T1.0000.48
136_T153_L0.9980.48
119_Q123_S0.9910.47
22_A88_G0.9790.46
154_G158_G0.9730.46
25_T30_V0.9720.46
193_A197_V0.9710.46
139_V193_A0.9680.46
49_A83_V0.9650.45
192_S195_G0.9610.45
19_T49_A0.9590.45
10_Q32_N0.9580.45
145_L168_T0.9530.45
40_N128_V0.9530.45
186_V192_S0.9480.44
12_L81_A0.9470.44
131_T159_A0.9370.43
43_P122_S0.9330.43
186_V189_T0.9310.43
82_P119_Q0.9240.43
5_S9_T0.9150.42
165_T184_T0.9100.42
101_L104_T0.9090.42
136_T146_G0.9080.41
37_L41_P0.9020.41
52_G119_Q0.8930.40
96_Q100_M0.8880.40
66_G91_V0.8880.40
43_P182_V0.8860.40
116_Q127_P0.8860.40
29_G95_G0.8830.40
18_S68_L0.8710.39
39_T132_V0.8710.39
148_P153_L0.8650.39
29_G91_V0.8650.39
44_V72_L0.8630.38
74_S85_T0.8590.38
43_P84_T0.8570.38
28_N156_V0.8560.38
19_T104_T0.8490.38
33_G55_V0.8350.37
128_V192_S0.8350.37
132_V135_T0.8330.36
18_S60_N0.8320.36
5_S130_S0.8250.36
88_G95_G0.8120.35
37_L135_T0.8120.35
59_G66_G0.8080.35
137_Q140_G0.8070.35
11_G15_V0.8000.34
48_V83_V0.7940.34
23_V26_L0.7920.34
116_Q137_Q0.7910.34
33_G44_V0.7870.34
149_V155_T0.7840.33
54_V90_V0.7830.33
57_D128_V0.7820.33
73_G79_P0.7800.33
89_G160_V0.7760.33
138_T155_T0.7660.32
142_A153_L0.7650.32
140_G194_G0.7650.32
101_L151_G0.7620.32
121_L181_G0.7520.31
157_G164_G0.7500.31
11_G83_V0.7470.31
71_S74_S0.7460.31
51_V83_V0.7420.31
9_T26_L0.7390.31
79_P84_T0.7360.30
152_L168_T0.7330.30
123_S130_S0.7330.30
145_L149_V0.7330.30
94_V166_Q0.7260.30
9_T170_A0.7240.30
80_L84_T0.7220.30
16_V180_G0.7180.29
11_G167_V0.7110.29
17_T23_V0.7100.29
185_G188_N0.7090.29
45_G88_G0.7080.29
137_Q148_P0.7070.29
130_S175_V0.7060.29
168_T176_T0.7050.29
98_V101_L0.7050.29
100_M104_T0.7030.29
8_T129_T0.6990.28
46_T118_T0.6980.28
36_Q40_N0.6980.28
105_L108_A0.6920.28
190_V194_G0.6900.28
17_T21_N0.6880.28
12_L32_N0.6880.28
192_S198_N0.6850.28
183_V190_V0.6800.27
10_Q39_T0.6790.27
83_V111_S0.6790.27
168_T183_V0.6750.27
11_G68_L0.6750.27
114_V125_I0.6740.27
105_L160_V0.6670.27
30_V108_A0.6670.27
156_V169_G0.6670.27
9_T17_T0.6650.26
158_G193_A0.6550.26
159_A163_A0.6550.26
18_S177_S0.6530.26
29_G51_V0.6520.26
9_T12_L0.6470.25
113_P116_Q0.6360.25
74_S130_S0.6340.25
96_Q121_L0.6330.25
46_T58_L0.6320.25
55_V98_V0.6310.25
47_T59_G0.6290.25
6_S10_Q0.6290.25
33_G118_T0.6270.24
44_V193_A0.6240.24
13_G19_T0.6180.24
10_Q17_T0.6140.24
68_L71_S0.6140.24
164_G180_G0.6110.24
83_V158_G0.6090.24
38_G73_G0.6070.23
50_S197_V0.6070.23
93_T173_N0.6060.23
14_G165_T0.6060.23
74_S172_G0.6060.23
18_S23_V0.6040.23
137_Q157_G0.6030.23
185_G198_N0.6030.23
5_S10_Q0.6020.23
25_T43_P0.6020.23
174_P182_V0.6010.23
68_L80_L0.6010.23
6_S17_T0.6000.23
185_G195_G0.5960.23
24_S108_A0.5950.23
35_G42_N0.5900.23
14_G66_G0.5900.23
81_A163_A0.5870.22
78_A84_T0.5860.22
160_V192_S0.5860.22
126_V174_P0.5860.22
136_T140_G0.5850.22
5_S31_S0.5780.22
42_N118_T0.5770.22
147_A155_T0.5760.22
139_V152_L0.5730.22
164_G187_G0.5720.22
68_L179_V0.5670.21
68_L133_T0.5670.21
56_S145_L0.5640.21
25_T50_S0.5640.21
190_V193_A0.5630.21
85_T91_V0.5630.21
15_V167_V0.5630.21
111_S166_Q0.5620.21
151_G169_G0.5620.21
17_T60_N0.5550.21
42_N47_T0.5540.21
19_T58_L0.5540.21
173_N177_S0.5540.21
83_V98_V0.5520.21
26_L51_V0.5490.21
37_L78_A0.5490.21
47_T105_L0.5460.20
39_T46_T0.5460.20
80_L115_Q0.5450.20
30_V34_L0.5440.20
144_G148_P0.5410.20
36_Q179_V0.5400.20
37_L133_T0.5380.20
23_V112_G0.5380.20
13_G17_T0.5360.20
177_S193_A0.5340.20
35_G118_T0.5300.20
67_G70_S0.5290.20
142_A159_A0.5280.20
181_G188_N0.5270.20
104_T112_G0.5230.19
69_V84_T0.5210.19
14_G50_S0.5180.19
15_V18_S0.5150.19
114_V121_L0.5140.19
130_S134_G0.5120.19
99_T103_D0.5110.19
73_G125_I0.5100.19
56_S63_S0.5080.19
69_V81_A0.5080.19
144_G152_L0.5070.19
51_V55_V0.5050.19
188_N192_S0.5050.19
161_A165_T0.5040.19
6_S39_T0.5030.19
26_L53_N0.5030.19
18_S166_Q0.5020.19
114_V137_Q0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ieqA 3 0.4523 26.8 0.906 Contact Map
2ch7A 2 0.8392 13.4 0.918 Contact Map
3g67A 2 0.9045 12.9 0.918 Contact Map
4f7gB 1 0.6683 10.8 0.921 Contact Map
3zx6A 2 0.9749 9.1 0.924 Contact Map
2b9bA 3 0.9497 9.1 0.924 Contact Map
2l7nA 1 0.6332 7.5 0.927 Contact Map
2bezC 3 0.3869 7.5 0.927 Contact Map
1g5gA 3 0.6683 7.3 0.927 Contact Map
3zqeA 1 0.5528 6.4 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0074 seconds.