Flot - PFAM28P - GREMLIN Contacts

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Flot - Flotillin

PFAM:	PF15975	Sequences: EAEAEAEAAKGEAEAIRAKGEAEAEGMRAKAEAENELSDAAIADQLLLALLEKLPEIVRESVKPLEKIDKITILDVGGLGGGGGGGGGGGGGSLADQVVSSALRYRAQAPLLDELLKEIGL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	121 (116)
Sequences:	5544 (2830)
Seq/√Len:	262.8
META:	0.904

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
21_E	25_E	3.736	1.00
20_G	26_G	3.641	1.00
17_R	21_E	3.099	1.00
17_R	25_E	2.834	1.00
63_K	66_E	2.819	1.00
28_R	32_E	2.624	1.00
56_E	59_R	2.575	1.00
49_A	52_E	2.510	1.00
5_E	12_E	2.288	1.00
60_E	63_K	2.243	1.00
27_M	30_K	2.123	1.00
3_E	7_E	2.092	1.00
59_R	63_K	2.077	1.00
16_I	19_K	2.072	1.00
58_V	61_S	1.992	1.00
5_E	8_A	1.967	1.00
25_E	29_A	1.950	1.00
53_K	56_E	1.931	1.00
4_A	8_A	1.869	1.00
10_K	14_E	1.819	1.00
31_A	34_E	1.677	1.00
56_E	60_E	1.667	1.00
8_A	12_E	1.649	1.00
21_E	29_A	1.603	1.00
7_E	11_G	1.599	1.00
19_K	23_E	1.588	1.00
37_L	41_A	1.570	1.00
7_E	10_K	1.543	1.00
35_N	38_S	1.510	1.00
3_E	10_K	1.481	1.00
25_E	28_R	1.479	1.00
14_E	18_A	1.466	1.00
27_M	34_E	1.382	1.00
53_K	57_I	1.356	1.00
6_A	10_K	1.324	1.00
45_Q	48_L	1.320	1.00
9_A	16_I	1.309	1.00
29_A	32_E	1.295	1.00
69_D	72_T	1.258	1.00
39_D	43_A	1.238	1.00
28_R	36_E	1.210	1.00
76_V	79_L	1.197	1.00
42_I	45_Q	1.161	1.00
32_E	36_E	1.141	1.00
113_D	117_K	1.134	1.00
41_A	45_Q	1.093	1.00
37_L	42_I	1.067	1.00
92_G	100_S	1.049	1.00
98_V	101_S	1.025	1.00
61_S	64_P	0.997	1.00
38_S	41_A	0.974	1.00
18_A	22_A	0.969	1.00
30_K	34_E	0.946	1.00
41_A	44_D	0.931	1.00
9_A	12_E	0.928	1.00
18_A	21_E	0.925	1.00
92_G	97_Q	0.917	1.00
106_R	113_D	0.917	1.00
10_K	18_A	0.916	1.00
20_G	23_E	0.915	1.00
26_G	30_K	0.914	1.00
37_L	40_A	0.898	1.00
42_I	46_L	0.895	1.00
40_A	43_A	0.893	1.00
34_E	45_Q	0.889	1.00
17_R	20_G	0.878	1.00
62_V	65_L	0.876	1.00
12_E	19_K	0.875	1.00
16_I	22_A	0.874	1.00
4_A	7_E	0.872	1.00
23_E	27_M	0.868	1.00
43_A	47_L	0.866	1.00
88_G	96_D	0.857	1.00
9_A	19_K	0.842	0.99
5_E	9_A	0.836	0.99
98_V	107_A	0.831	0.99
113_D	116_L	0.831	0.99
101_S	104_R	0.823	0.99
46_L	51_L	0.822	0.99
103_L	109_A	0.805	0.99
7_E	14_E	0.805	0.99
35_N	41_A	0.804	0.99
6_A	9_A	0.799	0.99
17_R	22_A	0.798	0.99
28_R	33_A	0.793	0.99
109_A	116_L	0.782	0.99
85_G	88_G	0.779	0.99
112_L	116_L	0.778	0.99
68_I	71_I	0.758	0.99
23_E	30_K	0.740	0.99
72_T	76_V	0.738	0.99
49_A	53_K	0.737	0.99
35_N	42_I	0.732	0.99
8_A	11_G	0.731	0.99
92_G	96_D	0.727	0.98
36_E	41_A	0.718	0.98
105_Y	108_Q	0.711	0.98
100_S	104_R	0.708	0.98
16_I	20_G	0.707	0.98
96_D	100_S	0.704	0.98
20_G	30_K	0.703	0.98
77_G	80_G	0.686	0.98
52_E	56_E	0.686	0.98
87_G	90_G	0.685	0.98
96_D	99_V	0.685	0.98
83_G	86_G	0.678	0.98
44_D	52_E	0.677	0.98
35_N	39_D	0.676	0.98
20_G	27_M	0.675	0.98
70_K	73_I	0.675	0.98
106_R	109_A	0.675	0.98
42_I	47_L	0.674	0.97
17_R	29_A	0.667	0.97
65_L	68_I	0.660	0.97
47_L	51_L	0.660	0.97
14_E	17_R	0.655	0.97
42_I	51_L	0.655	0.97
94_L	97_Q	0.652	0.97
40_A	44_D	0.648	0.97
19_K	22_A	0.645	0.97
88_G	92_G	0.635	0.96
109_A	113_D	0.620	0.96
4_A	12_E	0.619	0.96
108_Q	111_L	0.617	0.96
29_A	33_A	0.615	0.96
92_G	95_A	0.615	0.96
39_D	45_Q	0.614	0.96
14_E	19_K	0.605	0.95
94_L	98_V	0.604	0.95
67_K	71_I	0.603	0.95
96_D	104_R	0.598	0.95
103_L	113_D	0.596	0.95
91_G	95_A	0.593	0.95
94_L	99_V	0.592	0.95
40_A	46_L	0.590	0.95
93_S	96_D	0.584	0.94
114_E	117_K	0.583	0.94
112_L	115_L	0.574	0.94
30_K	33_A	0.572	0.94
3_E	11_G	0.571	0.94
47_L	55_P	0.571	0.94
102_A	105_Y	0.569	0.94
93_S	101_S	0.569	0.94
95_A	98_V	0.567	0.93
82_G	86_G	0.565	0.93
44_D	47_L	0.564	0.93
58_V	72_T	0.564	0.93
84_G	90_G	0.558	0.93
34_E	41_A	0.557	0.93
68_I	73_I	0.553	0.93
63_K	67_K	0.550	0.92
54_L	58_V	0.548	0.92
4_A	11_G	0.548	0.92
104_R	107_A	0.547	0.92
2_A	6_A	0.546	0.92
91_G	94_L	0.545	0.92
93_S	99_V	0.543	0.92
55_P	60_E	0.542	0.92
83_G	90_G	0.541	0.92
47_L	50_L	0.540	0.92
37_L	45_Q	0.531	0.91
99_V	108_Q	0.527	0.91
31_A	36_E	0.527	0.91
32_E	35_N	0.525	0.91
104_R	116_L	0.521	0.90
98_V	108_Q	0.519	0.90
85_G	90_G	0.516	0.90
6_A	11_G	0.515	0.90
12_E	18_A	0.513	0.90
87_G	91_G	0.511	0.89
36_E	40_A	0.509	0.89
88_G	91_G	0.506	0.89
99_V	104_R	0.504	0.89
15_A	18_A	0.500	0.88

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3bk6A	3	0.4215	56.8	0.857	Contact Map
2zuoA	7	0.8512	55	0.858	Contact Map
3n44F	1	0.1983	17.7	0.891	Contact Map
2wl8A	1	0.2562	15.8	0.894	Contact Map
3v6iB	1	0.4132	12.2	0.899	Contact Map
3r6mA	2	0.4132	7.5	0.908	Contact Map
3zeuA	1	0.405	7.2	0.908	Contact Map
2axcA	1	0.2066	5.6	0.913	Contact Map
4fdyA	1	0.1983	4.8	0.916	Contact Map
3s6pE	5	0.2893	3.5	0.921	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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