GREMLIN Database
Flot - Flotillin
PFAM: PF15975 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 121 (116)
Sequences: 5544 (2830)
Seq/√Len: 262.8
META: 0.904

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_E25_E3.7361.00
20_G26_G3.6411.00
17_R21_E3.0991.00
17_R25_E2.8341.00
63_K66_E2.8191.00
28_R32_E2.6241.00
56_E59_R2.5751.00
49_A52_E2.5101.00
5_E12_E2.2881.00
60_E63_K2.2431.00
27_M30_K2.1231.00
3_E7_E2.0921.00
59_R63_K2.0771.00
16_I19_K2.0721.00
58_V61_S1.9921.00
5_E8_A1.9671.00
25_E29_A1.9501.00
53_K56_E1.9311.00
4_A8_A1.8691.00
10_K14_E1.8191.00
31_A34_E1.6771.00
56_E60_E1.6671.00
8_A12_E1.6491.00
21_E29_A1.6031.00
7_E11_G1.5991.00
19_K23_E1.5881.00
37_L41_A1.5701.00
7_E10_K1.5431.00
35_N38_S1.5101.00
3_E10_K1.4811.00
25_E28_R1.4791.00
14_E18_A1.4661.00
27_M34_E1.3821.00
53_K57_I1.3561.00
6_A10_K1.3241.00
45_Q48_L1.3201.00
9_A16_I1.3091.00
29_A32_E1.2951.00
69_D72_T1.2581.00
39_D43_A1.2381.00
28_R36_E1.2101.00
76_V79_L1.1971.00
42_I45_Q1.1611.00
32_E36_E1.1411.00
113_D117_K1.1341.00
41_A45_Q1.0931.00
37_L42_I1.0671.00
92_G100_S1.0491.00
98_V101_S1.0251.00
61_S64_P0.9971.00
38_S41_A0.9741.00
18_A22_A0.9691.00
30_K34_E0.9461.00
41_A44_D0.9311.00
9_A12_E0.9281.00
18_A21_E0.9251.00
92_G97_Q0.9171.00
106_R113_D0.9171.00
10_K18_A0.9161.00
20_G23_E0.9151.00
26_G30_K0.9141.00
37_L40_A0.8981.00
42_I46_L0.8951.00
40_A43_A0.8931.00
34_E45_Q0.8891.00
17_R20_G0.8781.00
62_V65_L0.8761.00
12_E19_K0.8751.00
16_I22_A0.8741.00
4_A7_E0.8721.00
23_E27_M0.8681.00
43_A47_L0.8661.00
88_G96_D0.8571.00
9_A19_K0.8420.99
5_E9_A0.8360.99
98_V107_A0.8310.99
113_D116_L0.8310.99
101_S104_R0.8230.99
46_L51_L0.8220.99
103_L109_A0.8050.99
7_E14_E0.8050.99
35_N41_A0.8040.99
6_A9_A0.7990.99
17_R22_A0.7980.99
28_R33_A0.7930.99
109_A116_L0.7820.99
85_G88_G0.7790.99
112_L116_L0.7780.99
68_I71_I0.7580.99
23_E30_K0.7400.99
72_T76_V0.7380.99
49_A53_K0.7370.99
35_N42_I0.7320.99
8_A11_G0.7310.99
92_G96_D0.7270.98
36_E41_A0.7180.98
105_Y108_Q0.7110.98
100_S104_R0.7080.98
16_I20_G0.7070.98
96_D100_S0.7040.98
20_G30_K0.7030.98
77_G80_G0.6860.98
52_E56_E0.6860.98
87_G90_G0.6850.98
96_D99_V0.6850.98
83_G86_G0.6780.98
44_D52_E0.6770.98
35_N39_D0.6760.98
20_G27_M0.6750.98
70_K73_I0.6750.98
106_R109_A0.6750.98
42_I47_L0.6740.97
17_R29_A0.6670.97
65_L68_I0.6600.97
47_L51_L0.6600.97
14_E17_R0.6550.97
42_I51_L0.6550.97
94_L97_Q0.6520.97
40_A44_D0.6480.97
19_K22_A0.6450.97
88_G92_G0.6350.96
109_A113_D0.6200.96
4_A12_E0.6190.96
108_Q111_L0.6170.96
29_A33_A0.6150.96
92_G95_A0.6150.96
39_D45_Q0.6140.96
14_E19_K0.6050.95
94_L98_V0.6040.95
67_K71_I0.6030.95
96_D104_R0.5980.95
103_L113_D0.5960.95
91_G95_A0.5930.95
94_L99_V0.5920.95
40_A46_L0.5900.95
93_S96_D0.5840.94
114_E117_K0.5830.94
112_L115_L0.5740.94
30_K33_A0.5720.94
3_E11_G0.5710.94
47_L55_P0.5710.94
102_A105_Y0.5690.94
93_S101_S0.5690.94
95_A98_V0.5670.93
82_G86_G0.5650.93
44_D47_L0.5640.93
58_V72_T0.5640.93
84_G90_G0.5580.93
34_E41_A0.5570.93
68_I73_I0.5530.93
63_K67_K0.5500.92
54_L58_V0.5480.92
4_A11_G0.5480.92
104_R107_A0.5470.92
2_A6_A0.5460.92
91_G94_L0.5450.92
93_S99_V0.5430.92
55_P60_E0.5420.92
83_G90_G0.5410.92
47_L50_L0.5400.92
37_L45_Q0.5310.91
99_V108_Q0.5270.91
31_A36_E0.5270.91
32_E35_N0.5250.91
104_R116_L0.5210.90
98_V108_Q0.5190.90
85_G90_G0.5160.90
6_A11_G0.5150.90
12_E18_A0.5130.90
87_G91_G0.5110.89
36_E40_A0.5090.89
88_G91_G0.5060.89
99_V104_R0.5040.89
15_A18_A0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bk6A 3 0.4215 56.8 0.857 Contact Map
2zuoA 7 0.8512 55 0.858 Contact Map
3n44F 1 0.1983 17.7 0.891 Contact Map
2wl8A 1 0.2562 15.8 0.894 Contact Map
3v6iB 1 0.4132 12.2 0.899 Contact Map
3r6mA 2 0.4132 7.5 0.908 Contact Map
3zeuA 1 0.405 7.2 0.908 Contact Map
2axcA 1 0.2066 5.6 0.913 Contact Map
4fdyA 1 0.1983 4.8 0.916 Contact Map
3s6pE 5 0.2893 3.5 0.921 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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