GREMLIN Database
DUF4760 - Domain of unknown function (DUF4760)
PFAM: PF15956 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 141 (132)
Sequences: 1113 (1034)
Seq/√Len: 90.0
META: 0.837

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_E113_E4.7361.00
15_R19_D3.8411.00
80_A131_L3.5471.00
105_W129_E3.2951.00
116_R129_E3.1191.00
84_R130_W3.0971.00
85_R95_D3.0431.00
90_E134_R2.9011.00
28_E32_E2.6151.00
106_E136_K2.6131.00
82_G88_L2.5981.00
129_E133_K2.5181.00
90_E135_W2.4571.00
105_W112_I2.3031.00
76_Y104_D2.0991.00
10_R14_K2.0441.00
19_D23_K1.9001.00
95_D127_E1.8531.00
17_T88_L1.7631.00
90_E94_K1.6961.00
94_K98_R1.6771.00
114_E117_K1.6761.00
78_F88_L1.6451.00
6_R10_R1.5781.00
16_A19_D1.5171.00
84_R127_E1.4711.00
94_K135_W1.4430.99
79_I93_L1.3970.99
101_V128_F1.3820.99
78_F96_S1.3470.99
20_F78_F1.3220.99
36_K68_A1.3060.99
18_I88_L1.2790.99
81_V96_S1.2370.98
37_L78_F1.2340.98
76_Y97_F1.2260.98
73_L112_I1.2080.98
8_N11_I1.2050.98
91_E95_D1.1930.98
80_A84_R1.1840.98
83_I90_E1.1630.97
46_N49_K1.1530.97
16_A93_L1.1440.97
7_S11_I1.1400.97
70_R125_Y1.1200.97
132_A136_K1.1180.97
76_Y100_T1.1020.96
20_F79_I1.0990.96
13_R89_D1.0850.96
16_A78_F1.0630.96
105_W132_A1.0560.95
12_A15_R1.0500.95
123_T126_E1.0500.95
60_E64_E1.0400.95
83_I135_W1.0350.95
84_R95_D1.0350.95
83_I93_L1.0270.95
74_N135_W1.0160.94
105_W128_F1.0120.94
70_R111_Y1.0080.94
33_A68_A0.9770.93
66_R70_R0.9740.93
85_R91_E0.9670.93
59_S62_N0.9660.93
74_N90_E0.9480.92
73_L80_A0.9450.92
123_T127_E0.9430.92
78_F87_I0.9430.92
130_W134_R0.9370.92
13_R86_G0.9360.92
81_V97_F0.9240.91
69_I73_L0.9180.91
73_L125_Y0.9170.91
88_L96_S0.8970.90
80_A128_F0.8970.90
108_L112_I0.8910.89
105_W116_R0.8910.89
99_G121_N0.8880.89
98_R123_T0.8740.89
105_W109_E0.8700.88
25_R75_Y0.8670.88
93_L96_S0.8600.88
60_E63_E0.8600.88
114_E118_E0.8530.87
33_A71_Y0.8460.87
78_F93_L0.8440.87
102_I136_K0.8360.86
47_L50_F0.8120.85
115_L124_L0.8090.84
29_E32_E0.8080.84
84_R126_E0.8070.84
101_V131_L0.7950.83
21_L97_F0.7950.83
24_T27_D0.7850.83
13_R17_T0.7810.82
55_L59_S0.7810.82
45_K48_E0.7800.82
63_E67_E0.7750.82
25_R96_S0.7740.82
121_N124_L0.7700.81
80_A127_E0.7700.81
15_R22_L0.7640.81
26_N75_Y0.7570.80
43_S107_K0.7530.80
9_R12_A0.7470.79
80_A130_W0.7450.79
27_D31_I0.7400.79
30_F71_Y0.7390.79
98_R121_N0.7390.79
7_S10_R0.7350.78
6_R9_R0.7260.77
133_K136_K0.7220.77
21_L96_S0.7220.77
79_I97_F0.7160.76
98_R126_E0.7110.76
98_R102_I0.7110.76
81_V92_L0.7090.76
75_Y78_F0.7010.75
27_D30_F0.6950.74
74_N94_K0.6900.74
62_N65_E0.6890.74
102_I132_A0.6860.73
20_F86_G0.6840.73
16_A87_I0.6800.73
73_L108_L0.6790.72
21_L30_F0.6700.71
17_T20_F0.6680.71
107_K124_L0.6670.71
25_R30_F0.6670.71
126_E130_W0.6650.71
119_R124_L0.6630.71
48_E51_A0.6540.70
17_T99_G0.6470.69
8_N24_T0.6470.69
73_L82_G0.6450.69
91_E106_E0.6420.68
77_E135_W0.6390.68
25_R78_F0.6360.68
36_K39_K0.6360.68
49_K53_P0.6340.67
69_I108_L0.6270.66
9_R14_K0.6270.66
61_E65_E0.6230.66
46_N122_P0.6190.65
62_N117_K0.6190.65
108_L128_F0.6180.65
11_I14_K0.6180.65
128_F132_A0.6150.65
97_F115_L0.6130.65
20_F88_L0.6120.65
129_E132_A0.6090.64
34_L38_R0.6030.63
77_E82_G0.6000.63
101_V104_D0.5930.62
96_S100_T0.5910.62
17_T93_L0.5800.60
10_R32_E0.5800.60
37_L108_L0.5790.60
43_S48_E0.5770.60
42_D118_E0.5740.60
70_R96_S0.5740.60
21_L79_I0.5720.59
81_V127_E0.5710.59
81_V106_E0.5660.59
102_I111_Y0.5650.58
48_E117_K0.5650.58
52_F55_L0.5620.58
72_V98_R0.5560.57
8_N12_A0.5550.57
25_R88_L0.5550.57
9_R87_I0.5520.57
78_F111_Y0.5460.56
80_A101_V0.5430.55
103_R107_K0.5430.55
77_E99_G0.5410.55
76_Y102_I0.5410.55
84_R134_R0.5340.54
39_K60_E0.5330.54
74_N77_E0.5320.54
26_N34_L0.5310.54
51_A114_E0.5300.54
17_T98_R0.5300.54
98_R116_R0.5290.54
111_Y115_L0.5280.53
40_V43_S0.5230.53
79_I112_I0.5220.53
18_I22_L0.5170.52
26_N128_F0.5170.52
72_V100_T0.5160.52
35_K42_D0.5150.52
49_K62_N0.5120.51
75_Y97_F0.5120.51
81_V131_L0.5100.51
120_N136_K0.5080.51
63_E66_R0.5050.50
106_E133_K0.5010.50
21_L76_Y0.5000.50
16_A75_Y0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pz1A 2 0.6738 10 0.913 Contact Map
1vf6C 1 0.2908 4.3 0.927 Contact Map
2ld7B 1 0.3121 4.1 0.928 Contact Map
1xrsA 2 0.8227 4 0.928 Contact Map
3tweA 2 0.1631 2.3 0.936 Contact Map
2oy9A 2 0.5177 2.3 0.936 Contact Map
1oefA 1 0.1702 2.1 0.938 Contact Map
2noxA 6 0.922 1.7 0.941 Contact Map
2czyA 1 0.2837 1.7 0.941 Contact Map
3wqlA 2 0.8156 1.5 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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