GREMLIN Database
FidL_like - FidL-like putative membrane protein
PFAM: PF15941 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 86 (86)
Sequences: 525 (411)
Seq/√Len: 44.4
META: 0.451

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_K46_D4.4031.00
76_I84_F4.1021.00
10_Y45_P2.8631.00
14_R42_D2.6861.00
45_P48_I2.6561.00
20_Y82_P2.3481.00
2_T9_K2.2221.00
10_Y44_V2.1071.00
11_I43_N1.9640.99
70_N73_A1.9040.99
82_P86_C1.8130.98
13_S78_N1.7760.98
61_S74_Y1.7500.98
19_T34_T1.6480.97
78_N81_S1.6360.97
47_E71_D1.5300.96
36_I85_I1.4530.94
38_K42_D1.4320.94
35_K46_D1.4080.93
26_G67_K1.3450.91
5_S46_D1.3020.90
25_D66_I1.2790.89
29_Y68_K1.2770.89
30_R61_S1.2160.87
1_G4_T1.2150.87
14_R38_K1.2130.87
4_T7_G1.1920.86
26_G66_I1.1550.84
12_I64_L1.1390.83
14_R66_I1.1280.82
47_E51_K1.1270.82
62_R78_N1.1260.82
52_L55_F1.1080.81
49_F53_L1.0990.81
43_N68_K1.0980.80
18_F25_D1.0890.80
43_N58_P1.0680.79
28_T64_L1.0650.78
62_R81_S1.0650.78
12_I41_N1.0630.78
12_I75_L1.0320.76
62_R80_Y1.0290.76
5_S76_I1.0160.75
3_V34_T1.0030.74
20_Y70_N1.0000.74
13_S37_I0.9690.71
13_S63_Y0.9540.70
20_Y29_Y0.9370.69
9_K19_T0.9370.69
8_K11_I0.9350.69
33_I54_F0.9210.68
15_T41_N0.9030.66
52_L78_N0.8990.66
31_L55_F0.8850.64
24_D28_T0.8840.64
76_I83_L0.8830.64
22_R36_I0.8760.64
15_T37_I0.8700.63
8_K22_R0.8560.62
11_I32_T0.8510.61
18_F53_L0.8330.60
32_T72_N0.8150.58
40_P78_N0.8070.57
18_F79_L0.8040.57
25_D44_V0.7990.56
33_I56_S0.7910.56
12_I78_N0.7830.55
17_Y29_Y0.7810.55
65_K82_P0.7770.54
12_I29_Y0.7750.54
3_V9_K0.7740.54
12_I45_P0.7600.53
56_S59_G0.7550.52
31_L82_P0.7520.52
7_G17_Y0.7370.51
7_G71_D0.7370.51
29_Y67_K0.7340.50
16_I20_Y0.7260.49
77_S81_S0.7130.48
27_G76_I0.7100.48
64_L83_L0.7090.48
31_L77_S0.7090.48
73_A80_Y0.7070.48
25_D31_L0.7020.47
33_I79_L0.6910.46
51_K85_I0.6790.45
36_I46_D0.6780.45
32_T37_I0.6710.44
24_D27_G0.6690.44
11_I70_N0.6630.43
24_D32_T0.6550.43
42_D75_L0.6360.41
27_G37_I0.6320.40
20_Y40_P0.6270.40
4_T17_Y0.6260.40
37_I43_N0.6250.40
13_S81_S0.6210.39
68_K71_D0.6120.39
20_Y32_T0.6120.39
42_D74_Y0.6070.38
5_S8_K0.5990.37
25_D75_L0.5980.37
49_F55_F0.5940.37
6_N45_P0.5920.37
63_Y83_L0.5900.37
76_I79_L0.5790.36
40_P81_S0.5790.36
20_Y84_F0.5770.35
65_K77_S0.5740.35
31_L76_I0.5640.34
61_S64_L0.5630.34
18_F82_P0.5540.33
4_T9_K0.5530.33
37_I69_L0.5450.33
2_T5_S0.5340.32
13_S41_N0.5330.32
47_E68_K0.5240.31
3_V7_G0.5230.31
33_I75_L0.5220.31
11_I46_D0.5200.31
82_P85_I0.5190.31
12_I39_S0.5170.30
10_Y48_I0.5160.30
11_I35_K0.5130.30
7_G58_P0.5080.30
1_G10_Y0.5080.30
13_S22_R0.5020.29
55_F62_R0.5000.29
32_T46_D0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dx8H 1 0.5116 3.9 0.886 Contact Map
1lurA 1 0.9651 3.3 0.89 Contact Map
3n8bA 2 0.7907 3.3 0.89 Contact Map
1xcrA 1 0.7326 2.8 0.894 Contact Map
4orlA 1 0.407 2.4 0.898 Contact Map
4cfeA 1 0.7326 2.3 0.899 Contact Map
3vwcA 1 0.6977 2.3 0.899 Contact Map
4enzA 1 0.8721 2.2 0.9 Contact Map
2l0cA 1 0.3372 2.2 0.9 Contact Map
1nsxA 2 0.9767 2 0.901 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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