GREMLIN Database
BAT - GAF and HTH_10 associated domain
PFAM: PF15915 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 156 (147)
Sequences: 3483 (2795)
Seq/√Len: 230.5
META: 0.655

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_F82_L4.7911.00
98_A116_L4.1401.00
93_L98_A3.9221.00
101_R115_E3.1151.00
9_R109_G2.7201.00
30_L33_V2.5021.00
8_F126_V2.4421.00
70_L80_F2.3861.00
21_A108_G2.2901.00
56_E68_V2.2141.00
31_E79_L2.1511.00
31_E46_T2.1511.00
52_P78_G2.1271.00
47_V55_V2.1001.00
51_D54_A1.9921.00
129_L136_V1.9341.00
9_R139_V1.9131.00
138_L141_K1.8401.00
18_V110_W1.8381.00
70_L78_G1.8361.00
96_H128_A1.8101.00
122_V141_K1.8051.00
103_A112_L1.7661.00
56_E80_F1.7631.00
7_E111_R1.6811.00
118_D121_D1.6351.00
54_A57_A1.6001.00
100_V103_A1.5921.00
7_E142_R1.5821.00
74_G77_E1.5801.00
43_P84_V1.5781.00
69_R81_E1.5651.00
8_F129_L1.5531.00
59_A68_V1.5471.00
105_A110_W1.5051.00
23_A58_A1.4841.00
106_T109_G1.3641.00
55_V80_F1.3501.00
29_E48_T1.3491.00
56_E60_E1.3331.00
46_T79_L1.3311.00
30_L103_A1.3291.00
30_L43_P1.3131.00
3_V146_R1.2891.00
10_V136_V1.2591.00
27_T48_T1.2541.00
46_T77_E1.2401.00
129_L134_P1.2261.00
42_L83_T1.2181.00
92_T96_H1.1991.00
121_D124_E1.1831.00
9_R137_E1.1811.00
8_F114_V1.1771.00
28_V82_L1.1541.00
19_R23_A1.1411.00
33_V43_P1.1031.00
100_V114_V1.1011.00
123_R127_E1.1001.00
128_A132_R1.0941.00
88_S91_S1.0831.00
30_L44_Y1.0721.00
93_L114_V1.0681.00
70_L73_E1.0651.00
53_E56_E1.0511.00
91_S95_E1.0481.00
12_D18_V1.0431.00
26_C49_G1.0301.00
92_T128_A1.0281.00
114_V117_P1.0241.00
57_A60_E1.0171.00
7_E113_V1.0121.00
27_T106_T1.0081.00
21_A107_D1.0051.00
102_S113_V1.0041.00
52_P56_E1.0031.00
59_A65_V0.9961.00
45_F80_F0.9951.00
29_E104_T0.9521.00
26_C105_A0.9521.00
127_E131_E0.9461.00
7_E140_A0.9451.00
19_R62_D0.9401.00
40_T83_T0.9401.00
94_A97_G0.9361.00
21_A24_L0.9361.00
66_E83_T0.9261.00
66_E85_T0.9221.00
48_T77_E0.9221.00
145_E148_V0.9221.00
90_L100_V0.9201.00
20_L59_A0.9171.00
12_D15_F0.9060.99
57_A61_D0.8870.99
115_E146_R0.8760.99
115_E144_R0.8750.99
27_T104_T0.8670.99
36_R88_S0.8610.99
51_D120_A0.8550.99
3_V144_R0.8550.99
43_P114_V0.8480.99
67_D83_T0.8390.99
5_E113_V0.8390.99
139_V149_R0.8370.99
64_G85_T0.8290.99
59_A64_G0.8040.99
20_L58_A0.8040.99
4_V138_L0.7980.99
13_P16_P0.7970.99
108_G127_E0.7900.99
5_E140_A0.7890.99
19_R22_A0.7880.99
143_E147_P0.7720.98
65_V68_V0.7510.98
129_L133_Y0.7500.98
111_R139_V0.7360.98
62_D65_V0.7330.98
71_V79_L0.7300.98
90_L103_A0.7280.98
50_A55_V0.7250.98
54_A58_A0.7250.98
4_V13_P0.7210.97
44_Y71_V0.7200.97
56_E70_L0.7190.97
126_V130_R0.7180.97
19_R64_G0.7130.97
114_V125_F0.7100.97
40_T95_E0.7070.97
130_R134_P0.7060.97
20_L24_L0.6990.97
98_A114_V0.6960.97
127_E130_R0.6940.97
8_F128_A0.6920.97
3_V115_E0.6910.97
119_R141_K0.6910.97
17_L103_A0.6900.97
65_V71_V0.6870.97
55_V59_A0.6810.96
36_R116_L0.6710.96
126_V142_R0.6710.96
42_L81_E0.6690.96
35_P38_D0.6590.96
65_V84_V0.6590.96
16_P45_F0.6590.96
43_P100_V0.6570.96
9_R12_D0.6550.96
3_V80_F0.6500.95
12_D16_P0.6470.95
50_A78_G0.6460.95
14_D17_L0.6460.95
43_P90_L0.6430.95
11_T18_V0.6410.95
23_A98_A0.6380.95
80_F115_E0.6380.95
16_P20_L0.6370.95
35_P39_G0.6350.95
26_C47_V0.6280.94
129_L141_K0.6280.94
30_L45_F0.6230.94
29_E96_H0.6210.94
34_V103_A0.6170.94
133_Y141_K0.6150.94
89_L112_L0.6120.94
95_E131_E0.6100.94
15_F18_V0.6100.94
103_A110_W0.6080.93
15_F89_L0.6030.93
119_R130_R0.6010.93
36_R131_E0.6000.93
43_P47_V0.5990.93
16_P36_R0.5960.93
26_C88_S0.5960.93
123_R130_R0.5950.93
69_R90_L0.5930.93
68_V82_L0.5920.93
6_L138_L0.5890.92
52_P80_F0.5890.92
23_A26_C0.5880.92
17_L84_V0.5830.92
104_T111_R0.5810.92
97_G123_R0.5790.92
42_L103_A0.5780.92
10_V17_L0.5780.92
53_E57_A0.5710.91
128_A131_E0.5680.91
67_D121_D0.5680.91
56_E59_A0.5650.91
15_F115_E0.5650.91
11_T135_D0.5630.91
13_P29_E0.5570.90
119_R139_V0.5560.90
99_T115_E0.5530.90
32_G41_V0.5520.90
116_L125_F0.5520.90
33_V96_H0.5500.90
8_F138_L0.5500.90
47_V78_G0.5490.90
78_G121_D0.5480.89
75_D148_V0.5470.89
17_L20_L0.5470.89
41_V68_V0.5460.89
88_S97_G0.5420.89
15_F110_W0.5410.89
18_V108_G0.5360.88
101_R113_V0.5350.88
24_L58_A0.5290.88
21_A26_C0.5250.87
94_A100_V0.5240.87
28_V105_A0.5230.87
46_T82_L0.5210.87
46_T141_K0.5180.87
83_T89_L0.5150.86
44_Y81_E0.5130.86
23_A49_G0.5120.86
81_E117_P0.5090.86
8_F136_V0.5080.86
77_E85_T0.5080.86
131_E149_R0.5040.85
98_A107_D0.5040.85
74_G100_V0.5010.85
29_E41_V0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pwuA 4 0.5064 7.7 0.914 Contact Map
1zpvA 3 0.4936 4.9 0.922 Contact Map
2lvwA 2 0.5321 4.6 0.923 Contact Map
2w7vA 2 0.4936 4.6 0.923 Contact Map
2ko1A 2 0.5192 4.5 0.923 Contact Map
1u8sA 2 0.9295 4.4 0.923 Contact Map
2nyiA 2 0.891 4.1 0.925 Contact Map
3mtjA 3 0.5 3.9 0.926 Contact Map
2l26A 1 0.3974 3.8 0.926 Contact Map
3s30A 1 0 3.8 0.926 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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