GREMLIN Database
MBF2 - Transcription activator MBF2
PFAM: PF15868 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 88 (87)
Sequences: 528 (426)
Seq/√Len: 45.6
META: 0.188

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_L88_G4.4741.00
58_I68_V3.7211.00
43_E85_E3.1921.00
56_A70_I3.0951.00
72_L84_V2.9011.00
29_T71_R2.8261.00
54_G82_F2.4331.00
13_R85_E2.4241.00
4_R8_D2.0791.00
4_R7_G1.9130.99
54_G80_F1.8380.99
47_Q83_T1.7280.98
32_Y86_I1.6560.98
42_I68_V1.6510.97
46_D53_G1.6470.97
17_V81_N1.6420.97
70_I86_I1.5920.97
30_V84_V1.5670.96
4_R40_T1.5470.96
44_A82_F1.5380.96
25_V76_R1.5140.96
10_L85_E1.4320.94
39_I86_I1.4230.94
15_N81_N1.3540.92
31_T69_T1.2700.90
74_S79_G1.2500.89
60_S67_F1.2080.87
4_R43_E1.1570.85
4_R41_A1.1350.84
45_L85_E1.1300.83
46_D73_K1.1210.83
44_A71_R1.1210.83
19_S22_F1.1200.83
10_L19_S1.1110.82
37_E66_N1.0930.81
3_S6_P1.0830.81
30_V33_P1.0620.79
43_E55_Y1.0580.79
29_T69_T1.0480.78
39_I53_G1.0380.78
62_G68_V1.0090.76
12_Y15_N0.9830.74
31_T73_K0.9540.71
16_V72_L0.9510.71
56_A72_L0.9420.70
9_R29_T0.9340.70
48_K52_N0.9300.69
46_D74_S0.9140.68
37_E88_G0.9060.67
73_K76_R0.8760.65
57_S73_K0.8690.64
50_D75_Q0.8620.64
48_K79_G0.8150.59
57_S71_R0.8140.59
19_S24_R0.7980.58
9_R85_E0.7950.57
6_P14_E0.7950.57
10_L18_K0.7810.56
55_Y75_Q0.7810.56
62_G82_F0.7670.55
21_S24_R0.7650.54
54_G74_S0.7560.53
20_S23_L0.7480.53
8_D18_K0.7470.53
37_E60_S0.7340.51
23_L26_V0.7320.51
13_R55_Y0.7260.51
48_K84_V0.7220.50
40_T63_V0.7200.50
12_Y44_A0.7180.50
56_A86_I0.7130.49
58_I61_G0.7110.49
38_T42_I0.7040.48
17_V78_R0.7020.48
56_A76_R0.7010.48
28_V33_P0.6940.47
46_D54_G0.6870.47
10_L13_R0.6870.47
11_L86_I0.6850.47
52_N75_Q0.6850.47
40_T43_E0.6690.45
53_G71_R0.6690.45
54_G86_I0.6660.45
18_K78_R0.6640.44
30_V34_V0.6540.44
32_Y65_Y0.6540.44
68_V86_I0.6520.43
53_G82_F0.6510.43
49_T66_N0.6500.43
30_V36_N0.6410.42
12_Y17_V0.6350.42
42_I74_S0.6300.41
41_A63_V0.6230.41
58_I83_T0.6220.40
36_N64_G0.6190.40
15_N18_K0.6170.40
75_Q88_G0.6100.39
19_S63_V0.6070.39
82_F86_I0.6050.39
62_G88_G0.6030.39
24_R76_R0.5980.38
73_K84_V0.5950.38
18_K21_S0.5870.37
8_D40_T0.5800.37
61_G68_V0.5770.36
25_V71_R0.5690.36
2_G41_A0.5680.35
39_I67_F0.5670.35
42_I64_G0.5670.35
20_S48_K0.5610.35
25_V65_Y0.5580.35
71_R76_R0.5550.34
75_Q82_F0.5460.34
58_I63_V0.5410.33
31_T38_T0.5330.32
8_D88_G0.5300.32
3_S65_Y0.5280.32
19_S38_T0.5230.32
25_V77_G0.5210.31
7_G56_A0.5210.31
22_F74_S0.5200.31
40_T72_L0.5190.31
48_K82_F0.5190.31
7_G87_Y0.5170.31
21_S56_A0.5150.31
23_L77_G0.5150.31
2_G40_T0.5110.31
39_I79_G0.5100.30
49_T63_V0.5000.30
42_I70_I0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qqmA 1 0.9773 19.1 0.865 Contact Map
2wuhA 1 1 14.6 0.872 Contact Map
4ag4A 1 1 14.2 0.873 Contact Map
4a4aA 1 0.9091 14.1 0.873 Contact Map
2qqoA 1 0.9886 13.4 0.874 Contact Map
2qqjA 1 0.9773 13.3 0.875 Contact Map
4gz9A 2 0.9773 11.3 0.878 Contact Map
2qqkA 1 0.9432 11.2 0.879 Contact Map
1k12A 1 0.9545 11 0.879 Contact Map
2qqiA 1 0.9773 10.9 0.879 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0051 seconds.