GREMLIN Database
LRRC37 - Leucine-rich repeat-containing protein 37 family
PFAM: PF15779 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 72 (71)
Sequences: 884 (665)
Seq/√Len: 78.9
META: 0.007

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_Q10_T4.4491.00
7_Q12_T3.0081.00
29_H35_P1.9931.00
5_P11_P1.9651.00
62_P68_V1.9181.00
32_T35_P1.8321.00
19_K22_V1.8231.00
54_L61_T1.6531.00
56_L65_T1.5881.00
21_V28_H1.5881.00
2_E6_T1.5681.00
68_V72_P1.5340.99
66_T69_E1.5060.99
38_Q41_A1.4200.99
6_T10_T1.4080.99
11_P17_P1.3720.99
55_D59_T1.3400.98
49_V63_E1.3290.98
57_E62_P1.3190.98
6_T17_P1.3130.98
42_Q56_L1.2630.98
11_P14_P1.2500.97
66_T70_H1.2100.97
6_T15_P1.1860.97
17_P26_P1.1730.96
9_E12_T1.1650.96
32_T39_D1.1550.96
61_T70_H1.1460.96
49_V53_P1.1380.96
65_T71_S1.1060.95
2_E5_P1.1050.95
8_Q19_K1.1000.95
60_I71_S1.0660.94
54_L57_E1.0570.94
50_T56_L1.0490.93
7_Q28_H1.0470.93
39_D47_P1.0380.93
33_V49_V1.0330.93
8_Q26_P1.0320.93
53_P58_L1.0290.93
37_G51_V0.9710.90
44_P47_P0.9580.90
62_P66_T0.9550.89
39_D48_S0.9550.89
51_V56_L0.9530.89
20_E53_P0.9460.89
48_S57_E0.9400.89
57_E60_I0.9260.88
5_P12_T0.9000.87
30_E41_A0.8870.86
22_V27_V0.8810.85
43_H66_T0.8780.85
13_Q34_P0.8510.83
58_L61_T0.8420.83
23_A31_V0.8390.82
25_P31_V0.8340.82
7_Q35_P0.8240.81
42_Q71_S0.8120.80
57_E69_E0.8090.80
26_P37_G0.8070.80
36_P44_P0.8050.80
65_T72_P0.7960.79
38_Q53_P0.7800.78
21_V40_Q0.7780.77
44_P51_V0.7780.77
9_E18_P0.7690.77
44_P61_T0.7610.76
20_E23_A0.7550.75
5_P15_P0.7550.75
25_P68_V0.7500.75
16_E71_S0.7430.74
5_P30_E0.7350.73
19_K56_L0.7240.72
4_S15_P0.7080.70
28_H38_Q0.6930.69
67_E72_P0.6910.69
37_G47_P0.6830.68
58_L63_E0.6820.68
42_Q50_T0.6640.66
43_H47_P0.6600.65
21_V27_V0.6580.65
26_P41_A0.6540.64
47_P64_P0.6290.61
19_K24_Q0.6240.61
6_T9_E0.6230.61
35_P52_Q0.6180.60
13_Q65_T0.6080.59
19_K27_V0.6060.59
24_Q29_H0.6000.58
28_H34_P0.5970.57
17_P21_V0.5940.57
22_V38_Q0.5940.57
45_T54_L0.5910.57
12_T17_P0.5890.56
19_K33_V0.5770.55
50_T61_T0.5750.55
21_V62_P0.5720.54
20_E59_T0.5710.54
42_Q62_P0.5680.54
28_H33_V0.5680.54
56_L60_I0.5640.53
59_T63_E0.5600.53
36_P55_D0.5580.52
3_P50_T0.5370.50
3_P13_Q0.5190.47
32_T37_G0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5bwxA 2 0.3056 0.8 0.918 Contact Map
4gaaA 2 0.4861 0.8 0.92 Contact Map
4ghuB 1 0.1944 0.7 0.924 Contact Map
4x2uA 1 0.5139 0.6 0.926 Contact Map
2m9xA 1 0.5 0.6 0.927 Contact Map
2k4zA 1 0.5139 0.5 0.93 Contact Map
4qhpA 1 0.5278 0.5 0.93 Contact Map
3c66C 1 0.25 0.5 0.931 Contact Map
4nk6A 2 0.0556 0.5 0.931 Contact Map
3u9wA 1 0.5 0.4 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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