GREMLIN Database
Tox-URI2 - URI fold toxin 2
PFAM: PF15653 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 84 (81)
Sequences: 597 (528)
Seq/√Len: 58.6
META: 0.868

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_G71_W3.8381.00
24_I65_R3.4731.00
27_G36_P2.0621.00
30_N34_L2.0231.00
65_R69_L1.8551.00
30_N39_R1.7930.99
15_D53_R1.7570.99
24_I68_A1.7110.99
20_Y45_L1.6450.99
69_L72_E1.6170.99
28_P36_P1.5970.99
77_K81_K1.5950.99
4_S8_Q1.5900.99
12_E19_V1.5600.98
42_V56_A1.5100.98
24_I69_L1.4900.98
12_E57_R1.4480.97
9_H35_S1.4300.97
14_R55_E1.4170.97
64_G67_K1.4100.97
34_L39_R1.3860.97
26_G38_A1.3800.97
40_Y44_K1.3600.96
22_Y75_K1.3430.96
73_T77_K1.3420.96
77_K80_K1.3400.96
39_R56_A1.3370.96
67_K70_E1.3170.95
19_V22_Y1.3020.95
22_Y59_L1.2860.95
9_H25_S1.2660.94
45_L48_E1.2620.94
25_S35_S1.2170.93
39_R43_R1.1740.92
35_S41_Q1.1710.92
44_K48_E1.1440.91
21_K41_Q1.1240.90
32_D39_R1.1060.89
38_A42_V1.0980.89
34_L38_A1.0790.88
42_V46_N1.0630.87
38_A56_A1.0500.87
78_R81_K1.0490.86
29_I39_R1.0490.86
67_K78_R1.0400.86
27_G40_Y1.0310.86
29_I36_P1.0180.85
7_P61_G1.0090.84
69_L73_T0.9990.84
37_R41_Q0.9790.82
29_I34_L0.9780.82
20_Y50_G0.9580.81
14_R18_T0.9500.80
12_E59_L0.9340.79
49_A53_R0.9330.79
30_N36_P0.9320.79
6_K73_T0.9190.78
76_I80_K0.9060.77
43_R47_K0.8970.77
66_K70_E0.8670.74
16_K19_V0.8640.74
75_K78_R0.8600.73
78_R82_K0.8590.73
36_P40_Y0.8420.72
55_E79_Y0.8360.71
9_H15_D0.8310.71
13_I41_Q0.8260.70
26_G29_I0.8250.70
60_K71_W0.8240.70
5_T10_G0.8230.70
71_W74_E0.8110.69
9_H13_I0.8060.68
8_Q68_A0.7990.68
13_I68_A0.7920.67
22_Y79_Y0.7850.66
61_G64_G0.7650.64
10_G45_L0.7630.64
78_R83_H0.7610.64
37_R68_A0.7290.61
7_P64_G0.7240.60
67_K74_E0.7110.59
11_Y37_R0.7100.59
44_K52_M0.6960.57
13_I37_R0.6930.57
29_I42_V0.6640.54
52_M55_E0.6540.53
56_A59_L0.6490.52
6_K26_G0.6370.51
50_G70_E0.6330.50
22_Y78_R0.6310.50
19_V59_L0.6260.49
57_R82_K0.6200.49
26_G36_P0.6140.48
17_G70_E0.6090.48
5_T18_T0.5930.46
40_Y43_R0.5930.46
14_R57_R0.5740.44
9_H41_Q0.5700.43
52_M60_K0.5690.43
9_H37_R0.5680.43
8_Q22_Y0.5650.43
60_K63_P0.5560.42
13_I42_V0.5560.42
40_Y63_P0.5550.42
24_I72_E0.5530.41
16_K55_E0.5530.41
71_W75_K0.5530.41
64_G68_A0.5490.41
17_G49_A0.5470.41
73_T80_K0.5470.41
65_R73_T0.5440.40
14_R19_V0.5430.40
59_L78_R0.5360.40
42_V70_E0.5340.39
41_Q68_A0.5310.39
36_P44_K0.5280.39
74_E78_R0.5280.39
31_K67_K0.5260.39
4_S9_H0.5200.38
11_Y15_D0.5130.37
48_E52_M0.5080.37
8_Q65_R0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yd0A 1 0.9286 82.6 0.798 Contact Map
1yd6A 5 0.9286 81.1 0.801 Contact Map
2wshA 4 0.9881 75.1 0.812 Contact Map
1mk0A 1 0.9048 56.2 0.834 Contact Map
3oqgA 2 1 29.5 0.86 Contact Map
1zg2A 1 0.8214 17.3 0.874 Contact Map
1ywlA 1 0.869 12.3 0.882 Contact Map
4xlgA 1 0.7976 11.6 0.883 Contact Map
2lwfA 1 0.8929 6.1 0.898 Contact Map
3vn0A 2 0.5357 3.7 0.907 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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