GREMLIN Database
Tox-REase-7 - Restriction endonuclease fold toxin 7
PFAM: PF15649 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 86 (82)
Sequences: 874 (811)
Seq/√Len: 89.5
META: 0.896

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_R60_D4.5321.00
35_G44_T3.9031.00
49_V52_L3.7761.00
54_L62_A2.8171.00
18_R30_Y2.4281.00
31_R61_F2.2601.00
63_A67_Q2.0921.00
44_T75_Y2.0901.00
32_I61_F1.8571.00
4_G48_N1.6061.00
29_R60_D1.5881.00
42_T73_E1.5861.00
64_Y68_N1.5381.00
41_K70_L1.5321.00
19_I33_P1.5261.00
76_V80_T1.4951.00
36_L64_Y1.4761.00
64_Y70_L1.4721.00
15_N18_R1.4400.99
15_N19_I1.4110.99
50_K79_N1.3840.99
16_K19_I1.3030.99
44_T73_E1.2580.98
56_R59_R1.2500.98
37_T42_T1.2430.98
37_T70_L1.2340.98
43_L61_F1.2280.98
23_S28_A1.2030.98
17_K38_D1.1780.98
14_G17_K1.1710.97
43_L65_A1.1660.97
2_R6_A1.1530.97
25_T63_A1.1440.97
77_R80_T1.1150.97
14_G18_R1.0930.96
9_G13_I1.0810.96
25_T28_A1.0760.96
53_S56_R1.0710.96
24_L28_A1.0460.95
54_L59_R1.0400.95
1_G5_E1.0380.95
18_R32_I1.0290.95
51_Y81_K1.0140.94
8_A11_G1.0140.94
42_T71_T0.9740.93
8_A13_I0.9650.93
54_L85_P0.9610.92
3_A7_A0.9590.92
48_N77_R0.9480.92
58_L61_F0.9400.92
33_P36_L0.9380.92
53_S85_P0.9000.90
63_A66_Q0.8910.89
46_V75_Y0.8880.89
38_D70_L0.8620.88
19_I64_Y0.8570.87
23_S27_T0.8390.86
4_G46_V0.8260.85
22_P25_T0.8050.84
50_K77_R0.7600.80
19_I36_L0.7580.80
43_L70_L0.7420.79
59_R83_S0.7420.79
39_T42_T0.7400.78
43_L72_F0.7240.77
38_D64_Y0.7240.77
13_I35_G0.7220.77
52_L82_L0.7160.76
42_T70_L0.7130.76
11_G15_N0.7090.75
8_A35_G0.7000.75
24_L63_A0.6960.74
8_A44_T0.6930.74
6_A66_Q0.6820.73
51_Y83_S0.6820.73
61_F72_F0.6800.72
4_G7_A0.6750.72
81_K84_G0.6750.72
8_A15_N0.6730.72
12_D15_N0.6720.72
4_G77_R0.6720.72
28_A60_D0.6530.69
5_E14_G0.6500.69
30_Y56_R0.6450.68
22_P27_T0.6350.67
27_T56_R0.6330.67
62_A73_E0.6290.66
10_I14_G0.6280.66
35_G75_Y0.6220.66
51_Y56_R0.6210.65
37_T41_K0.6200.65
8_A12_D0.6190.65
9_G46_V0.6160.65
58_L66_Q0.6130.64
9_G12_D0.6060.64
36_L70_L0.5950.62
55_T80_T0.5920.62
35_G73_E0.5900.62
76_V82_L0.5780.60
24_L27_T0.5720.59
42_T75_Y0.5670.59
25_T29_R0.5660.58
65_A72_F0.5630.58
37_T74_L0.5610.58
66_Q76_V0.5570.57
53_S83_S0.5550.57
43_L62_A0.5480.56
37_T68_N0.5440.55
74_L82_L0.5410.55
36_L44_T0.5340.54
54_L72_F0.5340.54
49_V77_R0.5320.54
78_P84_G0.5260.53
55_T58_L0.5180.52
53_S59_R0.5150.51
12_D35_G0.5150.51
31_R72_F0.5140.51
58_L72_F0.5120.51
33_P61_F0.5080.51
27_T63_A0.5070.50
71_T75_Y0.5030.50
31_R58_L0.5010.50
58_L74_L0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1t0fA 2 1 16.4 0.886 Contact Map
3k93A 3 0.9884 13.9 0.89 Contact Map
1m0dA 2 0.9419 13.1 0.891 Contact Map
2wcwA 2 0.9651 9.8 0.897 Contact Map
3sm4A 3 0.9535 9.6 0.898 Contact Map
4k05A 2 0.9535 9.3 0.898 Contact Map
1ou9A 4 0.4767 8.4 0.9 Contact Map
3syyA 3 0.9767 7.3 0.903 Contact Map
3j65o 1 0 7 0.903 Contact Map
1gefA 2 0.907 6.9 0.904 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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