GREMLIN Database
Imm-NTF2-2 - NTF2 fold immunity protein
PFAM: PF15631 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 72 (67)
Sequences: 2794 (2264)
Seq/√Len: 276.6
META: 0.964

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_E54_A3.1661.00
59_S62_D2.6091.00
7_E23_K2.4981.00
29_L60_K2.3531.00
57_E67_R2.2061.00
59_S64_R2.0241.00
34_V57_E1.9351.00
41_L53_V1.9291.00
53_V71_G1.8371.00
13_I68_V1.8271.00
10_L56_I1.7941.00
4_K11_I1.7161.00
36_T57_E1.6941.00
8_A12_P1.6661.00
16_K20_E1.6071.00
20_E23_K1.5301.00
38_E55_E1.5181.00
28_T38_E1.4101.00
10_L54_A1.3991.00
55_E69_T1.3811.00
36_T55_E1.3301.00
26_K38_E1.3201.00
42_P45_S1.2871.00
7_E11_I1.2731.00
55_E67_R1.2581.00
3_I27_A1.2491.00
1_T8_A1.2011.00
24_P39_G1.1991.00
4_K7_E1.1771.00
34_V66_L1.1091.00
43_K46_L1.1041.00
55_E71_G1.0551.00
30_K36_T1.0121.00
18_Q22_E1.0111.00
26_K40_T0.9991.00
5_I58_I0.9981.00
11_I16_K0.9701.00
6_A10_L0.9581.00
27_A37_V0.9161.00
25_F54_A0.9131.00
11_I19_I0.8971.00
9_V63_G0.8971.00
29_L32_G0.8921.00
11_I20_E0.8911.00
32_G61_K0.8891.00
29_L34_V0.8701.00
42_P46_L0.8451.00
5_I9_V0.8240.99
18_Q21_S0.7900.99
28_T36_T0.7780.99
40_T43_K0.7730.99
5_I8_A0.7620.99
54_A70_H0.7550.99
1_T12_P0.7380.99
1_T5_I0.7250.99
9_V13_I0.7180.99
39_G53_V0.7180.99
7_E25_F0.7030.98
7_E24_P0.7030.98
15_G19_I0.7010.98
25_F35_W0.6940.98
29_L35_W0.6920.98
2_A63_G0.6840.98
30_K34_V0.6760.98
7_E19_I0.6750.98
52_G70_H0.6740.98
10_L19_I0.6670.98
4_K16_K0.6500.97
3_I40_T0.6380.97
41_L44_G0.6340.97
4_K8_A0.6340.97
57_E69_T0.6340.97
59_S66_L0.6250.97
24_P40_T0.6240.97
32_G60_K0.6180.96
20_E37_V0.6110.96
10_L25_F0.6100.96
32_G59_S0.6090.96
11_I25_F0.6090.96
30_K57_E0.5960.96
3_I7_E0.5950.96
2_A6_A0.5950.96
19_I54_A0.5930.95
27_A35_W0.5850.95
9_V56_I0.5630.94
22_E39_G0.5530.93
9_V65_I0.5500.93
56_I68_V0.5470.93
9_V12_P0.5420.93
5_I65_I0.5340.92
22_E70_H0.5330.92
19_I25_F0.5300.92
22_E53_V0.5300.92
41_L51_G0.5280.92
5_I12_P0.5240.92
38_E71_G0.5210.91
23_K54_A0.5090.90
60_K63_G0.5060.90
4_K63_G0.5000.90
14_Y72_K0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k90B 1 0.9306 33 0.828 Contact Map
4exrA 2 0.8194 25.2 0.837 Contact Map
2hi1A 2 0.8889 9.6 0.866 Contact Map
3nqzA 1 0.8611 8.2 0.87 Contact Map
2gu3A 1 0.8611 5.8 0.879 Contact Map
3c0fB 2 0.7917 5.2 0.881 Contact Map
1w36B 1 0.8889 4.8 0.883 Contact Map
4xchA 4 0.3333 3.7 0.889 Contact Map
1vm6A 4 0.6111 3.5 0.89 Contact Map
2rdyA 2 0.8194 3.2 0.893 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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