GREMLIN Database
TerY_C - TerY-C metal binding domain
PFAM: PF15616 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 129 (128)
Sequences: 604 (493)
Seq/√Len: 43.5
META: 0.856

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_H114_Y4.4571.00
93_K107_W3.6751.00
10_K107_W3.1761.00
54_F107_W2.7531.00
85_G89_C2.7441.00
10_K51_E2.6181.00
15_K109_G2.4941.00
86_F124_V2.4831.00
102_E111_T2.4361.00
104_T111_T2.2251.00
20_I75_P2.2011.00
17_P54_F2.1441.00
29_S32_G2.0810.99
126_R129_G2.0410.99
109_G112_G1.9610.99
95_H103_A1.7770.98
101_G113_T1.7620.98
43_L86_F1.7210.98
87_A97_I1.6680.97
87_A122_F1.6660.97
3_N6_V1.6350.97
8_L17_P1.5860.96
29_S33_D1.5730.96
16_K79_H1.5380.96
105_C108_C1.5350.95
65_K123_D1.5320.95
87_A114_Y1.5120.95
27_Q30_G1.5040.95
8_L127_G1.4500.94
66_I71_L1.4450.94
51_E107_W1.4340.93
16_K51_E1.4330.93
90_S110_N1.4200.93
88_V122_F1.3640.92
84_F94_I1.3510.91
46_A76_G1.3490.91
21_K47_F1.3080.90
2_E128_R1.3030.90
41_Y55_E1.3000.90
85_G88_V1.2990.90
13_K42_R1.2770.89
43_L56_L1.2700.88
118_G121_G1.2360.87
69_S121_G1.2300.87
12_Q82_N1.2260.87
23_E44_V1.2240.86
31_F35_G1.2010.85
98_G103_A1.1730.84
21_K45_G1.1710.84
20_I86_F1.1610.83
43_L75_P1.1360.82
22_Y74_A1.1250.81
17_P51_E1.1180.81
9_G75_P1.0870.79
16_K50_D1.0750.78
2_E95_H1.0690.78
66_I125_N1.0630.78
95_H112_G1.0490.77
97_I100_E1.0480.77
22_Y73_G1.0460.76
41_Y54_F1.0320.75
28_E31_F1.0200.75
117_G120_G1.0200.75
23_E79_H1.0190.74
2_E39_R1.0140.74
48_P79_H1.0030.73
28_E33_D0.9910.72
34_L63_N0.9670.71
19_L22_Y0.9660.70
9_G20_I0.9580.70
32_G37_N0.9370.68
42_R94_I0.9320.68
118_G124_V0.9210.67
27_Q33_D0.9150.66
10_K52_S0.9140.66
18_Y73_G0.9050.65
95_H106_P0.9010.65
113_T125_N0.8840.64
29_S38_T0.8780.63
97_I114_Y0.8680.62
45_G81_G0.8640.62
78_P96_C0.8580.61
77_C80_C0.8400.60
23_E76_G0.8380.59
7_L94_I0.8210.58
24_K73_G0.8070.56
77_C105_C0.8070.56
45_G53_Y0.8020.56
9_G85_G0.8000.56
70_E125_N0.8000.56
43_L53_Y0.7990.56
48_P89_C0.7940.55
11_C18_Y0.7900.55
30_G34_L0.7870.55
85_G97_I0.7860.54
79_H99_G0.7750.53
100_E103_A0.7700.53
77_C108_C0.7600.52
118_G126_R0.7520.51
41_Y53_Y0.7520.51
7_L23_E0.7510.51
11_C96_C0.7440.50
59_G62_N0.7420.50
14_T48_P0.7390.50
91_C96_C0.7390.50
28_E34_L0.7380.50
67_N121_G0.7320.49
2_E25_R0.7200.48
10_K15_K0.7190.48
87_A95_H0.7160.48
18_Y22_Y0.7130.48
103_A114_Y0.7130.48
77_C96_C0.7120.47
60_S94_I0.7100.47
80_C105_C0.7080.47
26_L29_S0.7070.47
8_L54_F0.6980.46
22_Y71_L0.6970.46
62_N65_K0.6960.46
82_N98_G0.6940.46
31_F34_L0.6920.46
113_T119_E0.6890.45
16_K23_E0.6880.45
53_Y57_S0.6840.45
26_L33_D0.6830.45
41_Y45_G0.6790.44
64_L128_R0.6720.44
53_Y56_L0.6710.44
44_V49_V0.6710.44
82_N106_P0.6700.43
54_F59_G0.6670.43
58_D66_I0.6640.43
107_W114_Y0.6610.43
88_V94_I0.6580.42
27_Q32_G0.6580.42
100_E124_V0.6550.42
10_K24_K0.6510.42
80_C108_C0.6490.41
44_V66_I0.6470.41
118_G123_D0.6390.41
42_R72_I0.6370.40
117_G124_V0.6370.40
4_F44_V0.6280.40
28_E32_G0.6250.39
44_V83_Q0.6230.39
80_C96_C0.6190.39
19_L23_E0.6170.39
39_R70_E0.6110.38
60_S63_N0.6110.38
74_A86_F0.6100.38
86_F89_C0.6090.38
99_G102_E0.6040.37
40_D72_I0.6020.37
90_S104_T0.6010.37
41_Y68_T0.5980.37
19_L50_D0.5970.37
22_Y54_F0.5960.37
20_I88_V0.5920.36
75_P86_F0.5850.36
96_C105_C0.5850.36
10_K93_K0.5840.36
27_Q37_N0.5820.35
41_Y47_F0.5720.35
22_Y81_G0.5670.34
6_V9_G0.5650.34
12_Q95_H0.5630.34
73_G85_G0.5620.34
41_Y71_L0.5590.33
102_E112_G0.5580.33
68_T71_L0.5490.33
107_W127_G0.5450.32
100_E112_G0.5410.32
3_N44_V0.5350.31
58_D128_R0.5340.31
96_C108_C0.5320.31
83_Q98_G0.5300.31
22_Y45_G0.5290.31
13_K39_R0.5280.31
102_E118_G0.5240.31
2_E70_E0.5240.31
62_N67_N0.5200.30
32_G127_G0.5190.30
39_R49_V0.5180.30
83_Q111_T0.5160.30
109_G125_N0.5130.30
112_G121_G0.5070.29
84_F90_S0.5050.29
29_S37_N0.5030.29
25_R28_E0.5020.29
51_E93_K0.5020.29
65_K101_G0.5010.29
51_E54_F0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xzlA 1 0.3566 72.7 0.9 Contact Map
2ct2A 1 0.5426 71.1 0.901 Contact Map
2wjyA 1 0.3953 64.3 0.905 Contact Map
4txaA 1 0.4496 64.2 0.905 Contact Map
2ectA 1 0.5349 60.1 0.908 Contact Map
2djbA 1 0.5039 60 0.908 Contact Map
2aklA 1 0.3798 57.3 0.909 Contact Map
2ea6A 1 0.4341 56.8 0.91 Contact Map
1gh9A 1 0.3643 52.3 0.912 Contact Map
2ecnA 1 0.5039 49.6 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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