GREMLIN Database
TerB_C - TerB-C domain
PFAM: PF15615 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 150 (133)
Sequences: 2242 (1982)
Seq/√Len: 171.9
META: 0.795

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
84_H123_K3.7291.00
18_L23_L3.6761.00
81_D84_H3.4901.00
102_L113_L2.8931.00
87_L116_A2.6981.00
94_R101_E2.6621.00
20_L23_L2.6281.00
90_L105_L2.4891.00
133_I139_I2.3421.00
125_F131_P2.1591.00
130_D142_N2.1561.00
26_I30_T2.0951.00
84_H119_S2.0731.00
106_A116_A1.9911.00
25_R29_E1.8971.00
135_G138_P1.8861.00
23_L27_R1.8811.00
22_R26_I1.8781.00
103_E107_R1.8431.00
90_L108_E1.8281.00
88_L132_L1.8151.00
95_P143_E1.7291.00
87_L102_L1.6721.00
99_R114_D1.6531.00
84_H116_A1.6021.00
104_A108_E1.5721.00
19_D22_R1.5611.00
117_I133_I1.5471.00
30_T33_V1.5411.00
94_R97_W1.5391.00
24_A28_A1.5341.00
29_E32_E1.5201.00
56_E61_P1.4991.00
30_T34_Q1.4601.00
105_L109_L1.4351.00
124_A132_L1.4341.00
125_F128_F1.4151.00
24_A27_R1.4121.00
33_V36_L1.4081.00
26_I33_V1.3851.00
31_A34_Q1.3531.00
54_P57_V1.3351.00
87_L106_A1.3251.00
21_S24_A1.3061.00
123_K145_Y1.3011.00
88_L120_I1.2931.00
130_D145_Y1.2861.00
114_D135_G1.2781.00
10_E13_R1.2601.00
57_V61_P1.1731.00
85_S89_R1.1671.00
98_S101_E1.1631.00
134_E142_N1.1541.00
70_L73_S1.1531.00
124_A128_F1.1241.00
60_P66_A1.1011.00
26_I29_E1.0881.00
52_P57_V1.0791.00
61_P69_A1.0741.00
125_F129_G1.0631.00
86_A89_R1.0601.00
89_R93_S1.0561.00
86_A109_L1.0551.00
118_D129_G1.0390.99
63_A66_A1.0140.99
59_E63_A1.0020.99
65_E68_E1.0000.99
99_R103_E0.9920.99
131_P142_N0.9840.99
58_E61_P0.9820.99
54_P65_E0.9500.99
91_L97_W0.9460.99
99_R135_G0.9450.99
26_I145_Y0.9450.99
90_L109_L0.9400.99
27_R30_T0.9330.99
91_L133_I0.9240.99
102_L133_I0.9170.99
34_Q38_A0.9170.99
40_I134_E0.9060.98
135_G140_E0.9000.98
52_P63_A0.8760.98
128_F145_Y0.8630.98
29_E130_D0.8460.98
54_P67_S0.8390.98
64_E68_E0.8380.97
22_R25_R0.8330.97
81_D87_L0.8330.97
102_L106_A0.8310.97
56_E63_A0.8270.97
30_T37_L0.8230.97
61_P64_E0.8140.97
30_T124_A0.8090.97
84_H112_M0.7990.97
55_P60_P0.7980.97
55_P61_P0.7980.97
53_A57_V0.7920.96
131_P134_E0.7920.96
38_A141_I0.7850.96
118_D140_E0.7830.96
26_I122_E0.7790.96
130_D144_D0.7700.96
81_D111_L0.7700.96
26_I37_L0.7480.95
59_E64_E0.7450.95
34_Q118_D0.7380.95
33_V37_L0.7380.95
55_P62_E0.7360.95
51_E55_P0.7360.95
30_T115_G0.7290.94
30_T123_K0.7190.94
57_V65_E0.7160.94
62_E70_L0.7120.94
92_L146_L0.7120.94
55_P64_E0.7110.94
58_E65_E0.7110.94
132_L149_L0.7070.93
30_T40_I0.7060.93
115_G131_P0.7010.93
112_M115_G0.6990.93
80_L112_M0.6910.93
53_A63_A0.6890.93
101_E104_A0.6850.92
51_E56_E0.6800.92
143_E146_L0.6780.92
11_A14_P0.6780.92
118_D125_F0.6750.92
52_P61_P0.6750.92
113_L117_I0.6650.91
51_E54_P0.6630.91
115_G118_D0.6600.91
59_E71_A0.6600.91
99_R137_D0.6580.91
34_Q125_F0.6580.91
58_E62_E0.6560.91
42_V45_E0.6510.90
102_L105_L0.6450.90
37_L118_D0.6380.89
26_I40_I0.6330.89
118_D122_E0.6280.89
27_R39_E0.6270.89
34_Q106_A0.6170.88
84_H122_E0.6140.88
66_A70_L0.6110.87
54_P60_P0.6080.87
30_T41_F0.6070.87
62_E67_S0.6060.87
60_P72_D0.6040.87
31_A35_E0.6030.87
52_P67_S0.6030.87
111_L115_G0.6010.86
56_E71_A0.5990.86
61_P70_L0.5980.86
57_V66_A0.5880.85
58_E68_E0.5860.85
52_P55_P0.5850.85
128_F142_N0.5840.85
25_R28_A0.5800.85
66_A69_A0.5690.83
26_I119_S0.5640.83
38_A42_V0.5630.83
54_P68_E0.5560.82
62_E65_E0.5540.82
61_P68_E0.5540.82
28_A32_E0.5520.82
51_E63_A0.5480.81
37_L40_I0.5470.81
26_I36_L0.5470.81
34_Q115_G0.5420.80
111_L116_A0.5410.80
53_A59_E0.5380.80
58_E67_S0.5350.79
23_L30_T0.5350.79
52_P59_E0.5340.79
26_I118_D0.5280.79
27_R128_F0.5280.79
18_L22_R0.5280.79
46_E73_S0.5280.79
37_L41_F0.5270.78
34_Q41_F0.5270.78
84_H115_G0.5270.78
26_I31_A0.5260.78
28_A31_A0.5250.78
123_K135_G0.5240.78
82_E86_A0.5230.78
60_P64_E0.5220.78
128_F148_E0.5210.78
57_V62_E0.5200.78
57_V68_E0.5200.78
23_L29_E0.5150.77
23_L34_Q0.5130.77
139_I145_Y0.5130.77
52_P62_E0.5110.76
60_P71_A0.5100.76
69_A73_S0.5080.76
18_L115_G0.5050.76
26_I123_K0.5040.75
86_A110_G0.5020.75
63_A69_A0.5020.75
52_P56_E0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hepA 1 0.2667 11.8 0.907 Contact Map
3nw0A 1 0.4867 10.8 0.909 Contact Map
3bhpA 3 0.2667 10.5 0.909 Contact Map
2jvdA 1 0.2667 10.4 0.91 Contact Map
2fi0A 1 0.5133 8.5 0.913 Contact Map
4un1A 1 0.48 6.7 0.917 Contact Map
4r6iA 2 0.5267 6.7 0.917 Contact Map
3sqnA 2 0.4867 6.4 0.918 Contact Map
2rnjA 1 0.4467 5.3 0.921 Contact Map
1je8A 2 0.4467 4.8 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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