TerB_C - PFAM28P - GREMLIN Contacts

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TerB_C - TerB-C domain

PFAM:	PF15615	Sequences: IEEELEEKAEAARPKITLDLSRLARIRAETAEVQELLAEIFVEEEEEEEEEPAPPEVEEPPEAEEASEALADSPAESLGLDEAHSALLRLLLSRPEWSREELEALARELGLMLDGAIDSINEKAFDAFGDPLIEGDDPIEINEDYLEELK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	150 (133)
Sequences:	2242 (1982)
Seq/√Len:	171.9
META:	0.795

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
84_H	123_K	3.729	1.00
18_L	23_L	3.676	1.00
81_D	84_H	3.490	1.00
102_L	113_L	2.893	1.00
87_L	116_A	2.698	1.00
94_R	101_E	2.662	1.00
20_L	23_L	2.628	1.00
90_L	105_L	2.489	1.00
133_I	139_I	2.342	1.00
125_F	131_P	2.159	1.00
130_D	142_N	2.156	1.00
26_I	30_T	2.095	1.00
84_H	119_S	2.073	1.00
106_A	116_A	1.991	1.00
25_R	29_E	1.897	1.00
135_G	138_P	1.886	1.00
23_L	27_R	1.881	1.00
22_R	26_I	1.878	1.00
103_E	107_R	1.843	1.00
90_L	108_E	1.828	1.00
88_L	132_L	1.815	1.00
95_P	143_E	1.729	1.00
87_L	102_L	1.672	1.00
99_R	114_D	1.653	1.00
84_H	116_A	1.602	1.00
104_A	108_E	1.572	1.00
19_D	22_R	1.561	1.00
117_I	133_I	1.547	1.00
30_T	33_V	1.541	1.00
94_R	97_W	1.539	1.00
24_A	28_A	1.534	1.00
29_E	32_E	1.520	1.00
56_E	61_P	1.499	1.00
30_T	34_Q	1.460	1.00
105_L	109_L	1.435	1.00
124_A	132_L	1.434	1.00
125_F	128_F	1.415	1.00
24_A	27_R	1.412	1.00
33_V	36_L	1.408	1.00
26_I	33_V	1.385	1.00
31_A	34_Q	1.353	1.00
54_P	57_V	1.335	1.00
87_L	106_A	1.325	1.00
21_S	24_A	1.306	1.00
123_K	145_Y	1.301	1.00
88_L	120_I	1.293	1.00
130_D	145_Y	1.286	1.00
114_D	135_G	1.278	1.00
10_E	13_R	1.260	1.00
57_V	61_P	1.173	1.00
85_S	89_R	1.167	1.00
98_S	101_E	1.163	1.00
134_E	142_N	1.154	1.00
70_L	73_S	1.153	1.00
124_A	128_F	1.124	1.00
60_P	66_A	1.101	1.00
26_I	29_E	1.088	1.00
52_P	57_V	1.079	1.00
61_P	69_A	1.074	1.00
125_F	129_G	1.063	1.00
86_A	89_R	1.060	1.00
89_R	93_S	1.056	1.00
86_A	109_L	1.055	1.00
118_D	129_G	1.039	0.99
63_A	66_A	1.014	0.99
59_E	63_A	1.002	0.99
65_E	68_E	1.000	0.99
99_R	103_E	0.992	0.99
131_P	142_N	0.984	0.99
58_E	61_P	0.982	0.99
54_P	65_E	0.950	0.99
91_L	97_W	0.946	0.99
99_R	135_G	0.945	0.99
26_I	145_Y	0.945	0.99
90_L	109_L	0.940	0.99
27_R	30_T	0.933	0.99
91_L	133_I	0.924	0.99
102_L	133_I	0.917	0.99
34_Q	38_A	0.917	0.99
40_I	134_E	0.906	0.98
135_G	140_E	0.900	0.98
52_P	63_A	0.876	0.98
128_F	145_Y	0.863	0.98
29_E	130_D	0.846	0.98
54_P	67_S	0.839	0.98
64_E	68_E	0.838	0.97
22_R	25_R	0.833	0.97
81_D	87_L	0.833	0.97
102_L	106_A	0.831	0.97
56_E	63_A	0.827	0.97
30_T	37_L	0.823	0.97
61_P	64_E	0.814	0.97
30_T	124_A	0.809	0.97
84_H	112_M	0.799	0.97
55_P	60_P	0.798	0.97
55_P	61_P	0.798	0.97
53_A	57_V	0.792	0.96
131_P	134_E	0.792	0.96
38_A	141_I	0.785	0.96
118_D	140_E	0.783	0.96
26_I	122_E	0.779	0.96
130_D	144_D	0.770	0.96
81_D	111_L	0.770	0.96
26_I	37_L	0.748	0.95
59_E	64_E	0.745	0.95
34_Q	118_D	0.738	0.95
33_V	37_L	0.738	0.95
55_P	62_E	0.736	0.95
51_E	55_P	0.736	0.95
30_T	115_G	0.729	0.94
30_T	123_K	0.719	0.94
57_V	65_E	0.716	0.94
62_E	70_L	0.712	0.94
92_L	146_L	0.712	0.94
55_P	64_E	0.711	0.94
58_E	65_E	0.711	0.94
132_L	149_L	0.707	0.93
30_T	40_I	0.706	0.93
115_G	131_P	0.701	0.93
112_M	115_G	0.699	0.93
80_L	112_M	0.691	0.93
53_A	63_A	0.689	0.93
101_E	104_A	0.685	0.92
51_E	56_E	0.680	0.92
143_E	146_L	0.678	0.92
11_A	14_P	0.678	0.92
118_D	125_F	0.675	0.92
52_P	61_P	0.675	0.92
113_L	117_I	0.665	0.91
51_E	54_P	0.663	0.91
115_G	118_D	0.660	0.91
59_E	71_A	0.660	0.91
99_R	137_D	0.658	0.91
34_Q	125_F	0.658	0.91
58_E	62_E	0.656	0.91
42_V	45_E	0.651	0.90
102_L	105_L	0.645	0.90
37_L	118_D	0.638	0.89
26_I	40_I	0.633	0.89
118_D	122_E	0.628	0.89
27_R	39_E	0.627	0.89
34_Q	106_A	0.617	0.88
84_H	122_E	0.614	0.88
66_A	70_L	0.611	0.87
54_P	60_P	0.608	0.87
30_T	41_F	0.607	0.87
62_E	67_S	0.606	0.87
60_P	72_D	0.604	0.87
31_A	35_E	0.603	0.87
52_P	67_S	0.603	0.87
111_L	115_G	0.601	0.86
56_E	71_A	0.599	0.86
61_P	70_L	0.598	0.86
57_V	66_A	0.588	0.85
58_E	68_E	0.586	0.85
52_P	55_P	0.585	0.85
128_F	142_N	0.584	0.85
25_R	28_A	0.580	0.85
66_A	69_A	0.569	0.83
26_I	119_S	0.564	0.83
38_A	42_V	0.563	0.83
54_P	68_E	0.556	0.82
62_E	65_E	0.554	0.82
61_P	68_E	0.554	0.82
28_A	32_E	0.552	0.82
51_E	63_A	0.548	0.81
37_L	40_I	0.547	0.81
26_I	36_L	0.547	0.81
34_Q	115_G	0.542	0.80
111_L	116_A	0.541	0.80
53_A	59_E	0.538	0.80
58_E	67_S	0.535	0.79
23_L	30_T	0.535	0.79
52_P	59_E	0.534	0.79
26_I	118_D	0.528	0.79
27_R	128_F	0.528	0.79
18_L	22_R	0.528	0.79
46_E	73_S	0.528	0.79
37_L	41_F	0.527	0.78
34_Q	41_F	0.527	0.78
84_H	115_G	0.527	0.78
26_I	31_A	0.526	0.78
28_A	31_A	0.525	0.78
123_K	135_G	0.524	0.78
82_E	86_A	0.523	0.78
60_P	64_E	0.522	0.78
128_F	148_E	0.521	0.78
57_V	62_E	0.520	0.78
57_V	68_E	0.520	0.78
23_L	29_E	0.515	0.77
23_L	34_Q	0.513	0.77
139_I	145_Y	0.513	0.77
52_P	62_E	0.511	0.76
60_P	71_A	0.510	0.76
69_A	73_S	0.508	0.76
18_L	115_G	0.505	0.76
26_I	123_K	0.504	0.75
86_A	110_G	0.502	0.75
63_A	69_A	0.502	0.75
52_P	56_E	0.500	0.75

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2hepA	1	0.2667	11.8	0.907	Contact Map
3nw0A	1	0.4867	10.8	0.909	Contact Map
3bhpA	3	0.2667	10.5	0.909	Contact Map
2jvdA	1	0.2667	10.4	0.91	Contact Map
2fi0A	1	0.5133	8.5	0.913	Contact Map
4un1A	1	0.48	6.7	0.917	Contact Map
4r6iA	2	0.5267	6.7	0.917	Contact Map
3sqnA	2	0.4867	6.4	0.918	Contact Map
2rnjA	1	0.4467	5.3	0.921	Contact Map
1je8A	2	0.4467	4.8	0.922	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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