GREMLIN Database
EH_Signature - EH_Signature domain
PFAM: PF15611 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 422 (394)
Sequences: 643 (579)
Seq/√Len: 29.2
META: 0.678

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
379_L382_L4.2611.00
409_H415_W4.1321.00
291_R416_Q4.0231.00
305_D350_R3.6911.00
366_C419_F3.6081.00
32_A36_F3.4431.00
346_A359_F3.4121.00
295_F420_A3.0851.00
272_D306_A3.0161.00
344_N359_F2.9011.00
75_L98_L2.8771.00
314_A317_A2.7891.00
380_P387_Y2.7841.00
379_L383_Y2.6601.00
26_D32_A2.5580.99
295_F299_Y2.4700.99
359_F363_G2.4470.99
50_R53_R2.3700.99
28_A32_A2.3700.99
51_E55_V2.3430.99
34_R38_R2.3190.99
29_L32_A2.2390.98
379_L387_Y2.2360.98
156_L160_G2.2360.98
25_D29_L2.2260.98
49_L53_R2.2130.98
138_D141_A2.2010.98
380_P383_Y2.1960.98
299_Y359_F2.1750.98
91_W95_R2.1220.98
348_I357_V2.0860.98
91_W94_L2.0510.97
257_S260_A2.0260.97
364_N367_Y1.9810.97
234_L238_A1.8880.95
128_L135_L1.8720.95
359_F369_Y1.8720.95
170_F174_A1.8660.95
390_L393_L1.8190.94
314_A345_S1.7850.94
219_L222_Y1.7840.94
372_Y376_P1.7830.94
222_Y231_H1.7760.94
126_K130_E1.7540.93
24_P32_A1.7530.93
215_L219_L1.7420.93
289_D359_F1.7380.93
246_R272_D1.7310.93
383_Y386_G1.7100.92
372_Y377_F1.7090.92
309_A348_I1.6920.92
20_P24_P1.6900.92
139_P143_L1.6800.92
48_S51_E1.6730.92
387_Y390_L1.6460.91
346_A367_Y1.6380.91
277_F298_R1.6360.91
399_K404_A1.6260.90
77_S328_F1.6200.90
32_A35_R1.6180.90
276_F360_S1.6140.90
48_S53_R1.6110.90
403_D406_R1.5740.89
26_D36_F1.5670.89
53_R56_C1.5600.88
269_T306_A1.5560.88
269_T272_D1.5470.88
376_P383_Y1.5440.88
16_G21_P1.5310.87
403_D407_R1.5260.87
359_F367_Y1.5250.87
357_V369_Y1.5120.87
22_P25_D1.5050.86
243_G360_S1.5040.86
52_L55_V1.5020.86
26_D29_L1.4880.86
374_A377_F1.4830.86
235_R277_F1.4810.86
149_R179_L1.4760.85
275_L280_L1.4640.85
125_V128_L1.4380.84
253_W415_W1.4370.84
95_R98_L1.4340.84
273_L308_V1.4270.83
239_L264_V1.4220.83
344_N363_G1.4220.83
144_A148_L1.4210.83
356_V366_C1.4170.83
46_L49_L1.4070.82
258_E262_A1.4060.82
376_P379_L1.4030.82
379_L384_T1.3850.81
246_R308_V1.3790.81
283_D358_E1.3780.81
71_L98_L1.3770.81
289_D307_W1.3770.81
382_L387_Y1.3770.81
140_C144_A1.3710.81
357_V366_C1.3640.80
416_Q419_F1.3570.80
20_P23_P1.3520.80
75_L135_L1.3410.79
304_S350_R1.3360.79
101_R104_R1.3360.79
31_A35_R1.3270.79
377_F381_D1.3260.78
314_A318_A1.3250.78
299_Y363_G1.3230.78
46_L53_R1.3220.78
275_L345_S1.3200.78
283_D362_S1.3190.78
78_Y170_F1.3190.78
311_G363_G1.3180.78
30_L34_R1.3140.78
307_W369_Y1.2980.77
381_D384_T1.2930.77
169_W174_A1.2830.76
289_D347_F1.2780.76
50_R55_V1.2730.76
272_D275_L1.2730.76
328_F332_M1.2720.75
386_G389_D1.2590.75
71_L101_R1.2550.74
18_A22_P1.2530.74
292_R415_W1.2500.74
247_L268_L1.2290.73
78_Y139_P1.2220.72
246_R269_T1.2210.72
380_P384_T1.2170.72
242_W348_I1.2060.71
28_A35_R1.2000.71
347_F364_N1.1940.71
310_L314_A1.1890.70
310_L318_A1.1860.70
291_R411_D1.1790.70
306_A349_M1.1750.69
26_D31_A1.1730.69
298_R420_A1.1700.69
25_D32_A1.1680.69
48_S55_V1.1660.69
376_P380_P1.1590.68
329_R339_L1.1590.68
253_W409_H1.1590.68
81_S84_P1.1560.68
291_R344_N1.1550.68
48_S56_C1.1510.68
244_D293_K1.1490.68
27_E31_A1.1470.68
25_D37_R1.1450.67
277_F347_F1.1400.67
70_C273_L1.1360.67
214_G308_V1.1330.67
279_L310_L1.1320.66
24_P29_L1.1310.66
351_I356_V1.1250.66
402_N405_K1.1220.66
24_P31_A1.1220.66
26_D30_L1.1210.66
234_L296_W1.1210.66
246_R268_L1.1180.65
98_L102_L1.1180.65
94_L98_L1.1140.65
293_K297_L1.1140.65
27_E36_F1.1140.65
336_L339_L1.1140.65
234_L264_V1.1100.65
127_T130_E1.1100.65
291_R298_R1.1070.65
144_A147_L1.1060.65
269_T303_I1.1050.65
329_R332_M1.1030.64
47_A52_L1.1030.64
284_D358_E1.0990.64
377_F380_P1.0850.63
267_W352_G1.0830.63
28_A31_A1.0810.63
330_A333_K1.0800.63
393_L398_L1.0790.63
152_L156_L1.0780.63
347_F361_H1.0780.63
156_L161_L1.0760.62
208_P216_A1.0710.62
52_L56_C1.0710.62
33_L37_R1.0670.62
28_A39_S1.0660.62
382_L390_L1.0630.62
283_D359_F1.0610.61
77_S134_L1.0600.61
398_L404_A1.0600.61
47_A53_R1.0570.61
273_L358_E1.0560.61
356_V368_I1.0560.61
253_W292_R1.0550.61
376_P384_T1.0530.61
237_F295_F1.0510.61
78_Y94_L1.0440.60
410_S413_G1.0410.60
358_E409_H1.0400.60
25_D28_A1.0400.60
372_Y375_D1.0350.59
291_R359_F1.0340.59
244_D295_F1.0290.59
311_G344_N1.0210.58
27_E34_R1.0200.58
201_L235_R1.0120.58
215_L242_W1.0110.58
210_L273_L1.0110.58
261_R308_V1.0100.58
31_A40_E1.0070.57
179_L192_E0.9960.56
27_E35_R0.9950.56
222_Y234_L0.9950.56
382_L385_G0.9930.56
288_M347_F0.9890.56
297_L300_L0.9880.56
292_R409_H0.9870.56
210_L219_L0.9850.56
384_T387_Y0.9840.56
48_S54_L0.9840.56
74_L284_D0.9830.55
66_L307_W0.9800.55
180_E217_L0.9780.55
308_V419_F0.9740.55
311_G346_A0.9680.54
288_M314_A0.9670.54
396_S399_K0.9670.54
223_D260_A0.9660.54
344_N357_V0.9660.54
296_W363_G0.9620.54
344_N369_Y0.9580.53
205_A243_G0.9560.53
47_A50_R0.9520.53
277_F360_S0.9520.53
254_S257_S0.9520.53
26_D33_L0.9480.53
144_A181_A0.9440.52
90_N97_F0.9420.52
57_V68_R0.9420.52
394_R398_L0.9420.52
127_T133_E0.9420.52
280_L349_M0.9410.52
320_R373_D0.9380.52
90_N94_L0.9320.51
30_L35_R0.9310.51
50_R56_C0.9280.51
306_A369_Y0.9280.51
217_L240_D0.9270.51
17_K20_P0.9250.51
399_K403_D0.9190.50
47_A51_E0.9140.50
266_R270_K0.9100.50
272_D305_D0.9090.50
50_R54_L0.9090.50
314_A329_R0.9070.49
275_L307_W0.9060.49
298_R359_F0.9040.49
340_G344_N0.9010.49
289_D362_S0.9000.49
242_W256_V0.8970.49
290_P298_R0.8940.48
243_G352_G0.8940.48
98_L116_F0.8900.48
273_L281_A0.8860.48
160_G164_I0.8850.48
135_L138_D0.8850.48
27_E39_S0.8830.48
296_W367_Y0.8810.47
147_L150_G0.8750.47
274_R278_E0.8750.47
75_L128_L0.8750.47
92_E136_T0.8740.47
299_Y420_A0.8740.47
283_D296_W0.8710.47
347_F359_F0.8710.47
222_Y263_M0.8710.47
277_F280_L0.8700.47
269_T308_V0.8680.46
125_V130_E0.8680.46
373_D376_P0.8650.46
261_R265_R0.8630.46
343_D361_H0.8630.46
383_Y389_D0.8590.46
236_D349_M0.8590.46
277_F299_Y0.8540.45
360_S366_C0.8540.45
270_K297_L0.8530.45
298_R358_E0.8520.45
35_R38_R0.8510.45
243_G253_W0.8500.45
269_T360_S0.8490.45
20_P28_A0.8490.45
261_R310_L0.8450.45
16_G22_P0.8430.45
306_A309_A0.8410.44
130_E139_P0.8410.44
139_P147_L0.8360.44
36_F40_E0.8310.44
110_R116_F0.8290.43
102_L125_V0.8260.43
296_W359_F0.8260.43
325_F330_A0.8250.43
49_L56_C0.8240.43
126_K137_E0.8230.43
133_E140_C0.8230.43
180_E192_E0.8220.43
29_L33_L0.8140.42
25_D33_L0.8120.42
51_E54_L0.8070.42
194_L240_D0.8060.42
273_L416_Q0.8010.41
296_W299_Y0.7990.41
139_P144_A0.7990.41
388_L393_L0.7980.41
91_W98_L0.7960.41
82_F227_D0.7960.41
261_R325_F0.7910.41
311_G339_L0.7910.41
323_R326_V0.7900.40
147_L258_E0.7890.40
20_P25_D0.7880.40
404_A408_I0.7870.40
297_L359_F0.7860.40
17_K23_P0.7830.40
215_L221_R0.7830.40
125_V131_H0.7780.40
68_R78_Y0.7770.39
24_P35_R0.7720.39
277_F283_D0.7700.39
292_R358_E0.7690.39
296_W348_I0.7690.39
347_F367_Y0.7690.39
348_I359_F0.7630.38
322_D325_F0.7620.38
22_P39_S0.7610.38
129_R132_R0.7610.38
32_A37_R0.7610.38
244_D306_A0.7610.38
292_R295_F0.7590.38
371_N376_P0.7580.38
373_D379_L0.7580.38
358_E367_Y0.7550.38
235_R297_L0.7540.38
308_V347_F0.7510.38
18_A23_P0.7500.37
47_A56_C0.7490.37
288_M361_H0.7480.37
87_P184_E0.7460.37
275_L297_L0.7460.37
167_G175_V0.7440.37
273_L306_A0.7420.37
130_E133_E0.7410.37
246_R345_S0.7400.37
400_N406_R0.7390.37
279_L318_A0.7330.36
26_D35_R0.7320.36
25_D39_S0.7320.36
383_Y387_Y0.7320.36
283_D314_A0.7290.36
305_D349_M0.7260.36
241_I288_M0.7250.36
169_W234_L0.7240.36
296_W349_M0.7230.36
398_L408_I0.7210.35
102_L135_L0.7210.35
253_W295_F0.7200.35
165_P171_W0.7160.35
217_L350_R0.7160.35
284_D346_A0.7160.35
77_S255_G0.7140.35
234_L299_Y0.7140.35
22_P27_E0.7130.35
341_S344_N0.7120.35
28_A36_F0.7110.35
400_N405_K0.7110.35
20_P26_D0.7100.35
32_A40_E0.7100.35
217_L307_W0.7100.35
19_S25_D0.7090.35
346_A357_V0.7080.34
371_N375_D0.7070.34
33_L36_F0.7070.34
29_L36_F0.7060.34
358_E415_W0.7060.34
404_A407_R0.7030.34
46_L54_L0.7000.34
189_E230_L0.6980.34
25_D34_R0.6950.34
157_E161_L0.6940.33
24_P33_L0.6930.33
291_R412_S0.6930.33
389_D393_L0.6930.33
303_I307_W0.6910.33
31_A38_R0.6900.33
379_L388_L0.6850.33
35_R39_S0.6830.33
30_L36_F0.6830.33
135_L141_A0.6820.33
347_F369_Y0.6800.32
308_V318_A0.6800.32
74_L276_F0.6750.32
372_Y381_D0.6750.32
68_R332_M0.6750.32
17_K30_L0.6740.32
143_L353_D0.6740.32
178_Y359_F0.6740.32
49_L52_L0.6730.32
401_R405_K0.6720.32
379_L385_G0.6710.32
130_E137_E0.6700.32
293_K366_C0.6680.32
291_R347_F0.6670.32
30_L41_D0.6650.31
273_L360_S0.6620.31
272_D307_W0.6620.31
157_E177_A0.6610.31
283_D367_Y0.6610.31
26_D34_R0.6610.31
201_L299_Y0.6590.31
79_F177_A0.6590.31
388_L394_R0.6580.31
246_R306_A0.6580.31
126_K132_R0.6580.31
144_A183_A0.6580.31
386_G392_R0.6560.31
410_S414_G0.6560.31
283_D289_D0.6540.31
257_S278_E0.6530.31
243_G310_L0.6520.31
281_A293_K0.6520.31
30_L33_L0.6520.31
27_E30_L0.6510.31
24_P30_L0.6490.30
193_R309_A0.6490.30
140_C143_L0.6480.30
381_D388_L0.6480.30
121_G135_L0.6480.30
315_A319_R0.6470.30
21_P29_L0.6460.30
196_E217_L0.6460.30
177_A351_I0.6440.30
23_P26_D0.6430.30
24_P39_S0.6420.30
23_P31_A0.6410.30
279_L288_M0.6410.30
373_D377_F0.6400.30
68_R163_G0.6370.30
214_G295_F0.6370.30
152_L160_G0.6360.30
218_L382_L0.6360.30
401_R406_R0.6350.29
359_F364_N0.6340.29
73_G97_F0.6340.29
275_L310_L0.6340.29
286_G291_R0.6310.29
359_F366_C0.6310.29
165_P175_V0.6280.29
32_A39_S0.6270.29
194_L385_G0.6260.29
16_G29_L0.6250.29
289_D361_H0.6250.29
124_W244_D0.6250.29
18_A39_S0.6250.29
22_P26_D0.6240.29
16_G20_P0.6240.29
346_A363_G0.6240.29
154_E157_E0.6240.29
269_T332_M0.6230.29
263_M289_D0.6210.29
118_S216_A0.6190.28
279_L329_R0.6170.28
92_E96_E0.6160.28
143_L328_F0.6140.28
245_P292_R0.6140.28
133_E143_L0.6130.28
17_K24_P0.6120.28
244_D345_S0.6090.28
230_L273_L0.6080.28
299_Y351_I0.6070.28
303_I350_R0.6070.28
357_V367_Y0.6070.28
171_W175_V0.6070.28
235_R279_L0.6060.28
263_M359_F0.6060.28
244_D281_A0.6050.28
328_F349_M0.6030.27
80_R94_L0.6010.27
311_G314_A0.6000.27
405_K408_I0.5990.27
261_R272_D0.5990.27
284_D360_S0.5980.27
385_G388_L0.5970.27
48_S52_L0.5970.27
169_W178_Y0.5960.27
392_R403_D0.5950.27
31_A36_F0.5940.27
284_D287_R0.5940.27
258_E322_D0.5930.27
276_F293_K0.5920.27
110_R115_S0.5920.27
24_P38_R0.5910.27
210_L213_I0.5900.27
17_K22_P0.5890.27
175_V359_F0.5890.27
289_D296_W0.5880.27
161_L238_A0.5860.26
24_P27_E0.5860.26
318_A369_Y0.5850.26
396_S402_N0.5840.26
363_G367_Y0.5830.26
98_L148_L0.5820.26
331_R349_M0.5810.26
246_R280_L0.5800.26
20_P47_A0.5790.26
149_R166_D0.5790.26
62_V148_L0.5790.26
218_L226_P0.5780.26
78_Y349_M0.5780.26
29_L39_S0.5760.26
57_V61_E0.5750.26
125_V129_R0.5730.26
23_P29_L0.5720.26
126_K133_E0.5710.25
283_D345_S0.5700.25
46_L50_R0.5700.25
400_N404_A0.5700.25
94_L357_V0.5650.25
21_P26_D0.5630.25
33_L38_R0.5630.25
277_F359_F0.5610.25
260_A296_W0.5610.25
373_D383_Y0.5610.25
220_P359_F0.5600.25
74_L273_L0.5600.25
71_L269_T0.5600.25
344_N367_Y0.5590.25
22_P32_A0.5570.25
17_K21_P0.5560.25
56_C258_E0.5560.25
394_R397_E0.5540.24
75_L79_F0.5510.24
122_P139_P0.5480.24
393_L399_K0.5470.24
92_E324_D0.5460.24
168_S171_W0.5450.24
241_I277_F0.5440.24
31_A39_S0.5440.24
71_L219_L0.5420.24
212_D242_W0.5400.24
277_F285_L0.5390.24
263_M285_L0.5390.24
306_A368_I0.5370.24
380_P389_D0.5370.24
300_L354_Y0.5370.24
277_F346_A0.5370.24
374_A379_L0.5370.24
289_D367_Y0.5370.24
299_Y346_A0.5350.23
165_P299_Y0.5350.23
229_E233_A0.5340.23
123_D259_E0.5330.23
397_E400_N0.5330.23
378_S383_Y0.5320.23
246_R295_F0.5300.23
94_L303_I0.5300.23
274_R297_L0.5300.23
71_L128_L0.5290.23
277_F349_M0.5290.23
164_I221_R0.5270.23
266_R304_S0.5270.23
303_I312_S0.5250.23
135_L139_P0.5250.23
306_A325_F0.5240.23
249_S353_D0.5230.23
410_S416_Q0.5220.23
97_F268_L0.5200.23
179_L218_L0.5190.23
247_L264_V0.5180.22
147_L236_D0.5150.22
344_N347_F0.5150.22
387_Y392_R0.5130.22
290_P324_D0.5120.22
19_S22_P0.5110.22
128_L131_H0.5110.22
70_C98_L0.5100.22
242_W357_V0.5100.22
291_R296_W0.5100.22
384_T391_S0.5040.22
94_L110_R0.5040.22
380_P391_S0.5020.22
376_P387_Y0.5000.21
326_V353_D0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q1vA 1 0.1635 5.4 0.973 Contact Map
4cndA 2 0.0166 4.8 0.974 Contact Map
4x2uA 1 0.5095 4.7 0.974 Contact Map
1t3jA 2 0.1469 4.6 0.974 Contact Map
1ny9A 1 0.2109 3.5 0.975 Contact Map
4x86A 1 0.1209 3.3 0.976 Contact Map
2ekoA 1 0.1422 3.2 0.976 Contact Map
3c4rA 4 0.2867 2.9 0.977 Contact Map
1a32A 1 0.2014 2.8 0.977 Contact Map
4irlA 1 0.2512 2.8 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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