GREMLIN Database
Ntox44 - Bacterial toxin 44
PFAM: PF15607 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 100 (96)
Sequences: 1615 (1439)
Seq/√Len: 146.9
META: 0.85

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_G64_L5.3121.00
7_K10_G3.9371.00
61_E95_I3.1701.00
49_H53_V3.0461.00
5_L11_P2.6951.00
48_I97_L2.6771.00
55_R95_I2.4221.00
60_S63_T2.3541.00
14_Y49_H2.3061.00
14_Y46_G2.2451.00
65_L88_Q2.1511.00
65_L92_K2.1411.00
55_R99_K2.1361.00
3_Y7_K2.0621.00
55_R61_E2.0311.00
71_A75_S1.9731.00
44_D90_A1.8921.00
59_F63_T1.6371.00
8_T71_A1.6291.00
92_K96_D1.6101.00
61_E92_K1.5511.00
12_W49_H1.4951.00
52_Y97_L1.4591.00
67_G70_A1.4371.00
14_Y45_F1.3611.00
56_A98_Y1.3561.00
8_T75_S1.3371.00
69_G81_Y1.3181.00
55_R98_Y1.3161.00
90_A93_I1.2871.00
70_A74_G1.2711.00
12_W53_V1.2591.00
34_F38_G1.2251.00
72_Q83_D1.2191.00
50_Y67_G1.1921.00
93_I97_L1.1180.99
69_G82_G1.0960.99
48_I93_I1.0320.99
62_S66_R1.0250.99
69_G88_Q1.0100.99
64_L95_I0.9710.98
67_G71_A0.9280.98
89_A93_I0.9270.98
6_V54_G0.9200.98
40_Y44_D0.9120.98
83_D87_D0.9050.97
4_N7_K0.9040.97
42_Y45_F0.9000.97
3_Y67_G0.8810.97
61_E99_K0.8710.97
9_G16_P0.8610.97
68_A84_D0.8510.96
69_G72_Q0.8510.96
14_Y53_V0.8460.96
73_I82_G0.8410.96
54_G95_I0.8400.96
45_F49_H0.8150.95
71_A74_G0.8110.95
40_Y48_I0.8030.95
24_T27_V0.7870.94
61_E96_D0.7800.94
44_D48_I0.7790.94
17_K20_K0.7750.94
48_I52_Y0.7710.94
69_G83_D0.7680.94
68_A88_Q0.7630.93
2_F67_G0.7510.93
43_D87_D0.7470.93
93_I96_D0.7400.92
29_T32_G0.7360.92
68_A83_D0.7310.92
4_N10_G0.7290.92
26_G29_T0.7200.91
86_R89_A0.7020.90
77_T80_P0.6990.90
8_T16_P0.6960.90
2_F5_L0.6960.90
92_K95_I0.6950.90
41_T46_G0.6890.89
44_D86_R0.6790.89
2_F50_Y0.6790.89
68_A72_Q0.6700.88
3_Y70_A0.6670.88
79_R86_R0.6660.88
50_Y64_L0.6620.87
96_D99_K0.6620.87
8_T74_G0.6530.87
48_I90_A0.6500.86
41_T44_D0.6500.86
2_F14_Y0.6490.86
47_N87_D0.6490.86
15_K47_N0.6480.86
53_V57_A0.6480.86
66_R82_G0.6440.86
61_E65_L0.6410.86
95_I99_K0.6390.85
3_Y10_G0.6390.85
2_F53_V0.6370.85
30_Y33_K0.6330.85
5_L10_G0.6300.85
46_G49_H0.6180.83
6_V64_L0.6070.82
3_Y63_T0.6060.82
88_Q91_I0.6010.82
44_D93_I0.5960.81
74_G77_T0.5900.81
6_V50_Y0.5880.80
3_Y8_T0.5840.80
2_F6_V0.5830.80
66_R70_A0.5770.79
25_I28_G0.5740.79
18_I21_W0.5700.78
57_A90_A0.5690.78
27_V31_P0.5650.78
63_T66_R0.5650.78
62_S65_L0.5620.77
3_Y71_A0.5620.77
69_G73_I0.5600.77
40_Y43_D0.5540.76
43_D86_R0.5530.76
68_A71_A0.5500.76
27_V32_G0.5490.76
66_R73_I0.5480.75
81_Y88_Q0.5470.75
34_F37_N0.5360.74
22_F26_G0.5340.74
2_F46_G0.5310.73
34_F42_Y0.5290.73
64_L91_I0.5290.73
84_D87_D0.5260.73
68_A75_S0.5230.72
68_A91_I0.5200.72
89_A92_K0.5200.72
24_T32_G0.5190.72
59_F64_L0.5150.71
18_I22_F0.5140.71
20_K30_Y0.5080.70
50_Y63_T0.5070.70
74_G78_S0.5070.70
23_G26_G0.5060.70
43_D72_Q0.5060.70
3_Y74_G0.5050.69
31_P34_F0.5050.69
74_G99_K0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qjyB 1 0.34 6.4 0.905 Contact Map
3cx5D 2 0.36 3.2 0.918 Contact Map
1pp9D 2 0.35 2.3 0.923 Contact Map
1qvbA 3 0.52 2.1 0.926 Contact Map
4cd8A 1 0.68 1.7 0.929 Contact Map
4inoA 1 0.39 1.7 0.929 Contact Map
3craA 2 0.8 1.6 0.93 Contact Map
3ui3A 2 0.32 1.6 0.931 Contact Map
1nmlA 2 0.4 1.5 0.931 Contact Map
1uwiA 4 0.53 1.5 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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