GREMLIN Database
Ntox15 - Novel toxin 15
PFAM: PF15604 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 156 (148)
Sequences: 501 (431)
Seq/√Len: 35.4
META: 0.623

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_A121_S7.9191.00
94_L97_P3.5281.00
92_A117_R3.1801.00
30_R135_D2.9101.00
61_L65_L2.5961.00
46_Q50_R2.4981.00
17_G97_P2.4291.00
109_D112_I2.2690.99
152_N155_L2.1370.99
87_W91_L2.0630.99
18_L134_L2.0580.99
12_K16_D2.0240.98
26_Y135_D2.0030.98
117_R121_S1.9470.98
101_A127_W1.9230.98
122_S125_S1.9180.98
145_G149_T1.9100.98
10_Q14_Q1.8150.97
17_G94_L1.7650.96
122_S126_Q1.7340.96
24_D28_E1.7060.95
64_K68_L1.7010.95
44_A48_A1.7010.95
141_A145_G1.6690.95
17_G96_N1.6680.95
13_G96_N1.5940.93
13_G94_L1.5500.92
22_T25_E1.5330.92
72_G75_E1.5230.92
80_A84_A1.5200.92
79_E82_K1.5050.91
6_E9_R1.4920.91
20_N150_K1.4740.90
65_L69_G1.4290.89
136_E140_K1.4190.89
145_G148_K1.4090.88
31_E35_K1.4060.88
33_Y99_M1.4060.88
142_P146_R1.3880.88
13_G97_P1.3820.87
116_D119_V1.3780.87
18_L21_L1.3740.87
13_G17_G1.3480.86
118_R122_S1.3450.86
131_V135_D1.3160.85
141_A146_R1.2910.83
92_A119_V1.2650.82
142_P145_G1.2460.81
84_A87_W1.2420.81
24_D147_G1.2410.81
12_K15_E1.2200.80
146_R149_T1.1980.78
138_A141_A1.1900.78
23_V145_G1.1570.76
110_D113_G1.1520.76
15_E19_N1.1510.76
18_L129_S1.1380.75
29_N102_G1.1300.74
83_K86_E1.1300.74
129_S132_D1.1280.74
93_A100_I1.1210.74
130_R135_D1.1050.73
60_A64_K1.1020.72
76_A88_M1.1020.72
14_Q115_G1.0930.72
94_L115_G1.0720.70
26_Y30_R1.0720.70
33_Y38_R1.0420.68
141_A149_T1.0370.68
12_K24_D1.0370.68
96_N116_D1.0330.67
45_A50_R1.0100.66
95_H124_G0.9990.65
95_H98_D0.9970.65
46_Q49_A0.9950.64
50_R53_Y0.9850.64
27_L31_E0.9840.63
38_R46_Q0.9800.63
9_R96_N0.9760.63
29_N87_W0.9700.62
11_L123_I0.9560.61
29_N53_Y0.9540.61
50_R57_L0.9490.61
98_D124_G0.9480.61
37_G122_S0.9430.60
93_A101_A0.9430.60
38_R50_R0.9380.60
15_E93_A0.8860.55
7_F126_Q0.8750.54
135_D139_E0.8730.54
142_P149_T0.8700.54
54_Q58_E0.8620.53
82_K86_E0.8620.53
108_K112_I0.8600.53
14_Q94_L0.8510.52
9_R14_Q0.8480.52
72_G76_A0.8470.52
138_A145_G0.8460.52
42_G45_A0.8440.52
102_G127_W0.8340.51
16_D20_N0.8330.51
9_R13_G0.8300.51
133_E136_E0.8150.49
33_Y125_S0.8100.49
42_G99_M0.8050.48
21_L116_D0.8040.48
61_L73_L0.8040.48
8_D12_K0.8020.48
95_H120_N0.7950.47
139_E143_K0.7940.47
29_N126_Q0.7930.47
55_R59_E0.7900.47
57_L67_E0.7870.47
22_T94_L0.7800.46
109_D113_G0.7750.46
41_E46_Q0.7690.45
38_R44_A0.7680.45
24_D146_R0.7530.44
64_K87_W0.7520.44
119_V138_A0.7470.43
68_L72_G0.7400.43
74_S140_K0.7350.42
114_L122_S0.7330.42
7_F123_I0.7330.42
118_R121_S0.7310.42
53_Y57_L0.7210.41
52_K56_K0.7150.41
57_L65_L0.7150.41
93_A151_M0.7140.41
22_T26_Y0.7100.40
57_L79_E0.7090.40
100_I129_S0.7030.40
120_N124_G0.7010.40
76_A81_E0.7010.40
98_D120_N0.6980.39
26_Y99_M0.6970.39
66_R70_K0.6920.39
59_E78_K0.6840.38
33_Y36_R0.6810.38
143_K146_R0.6810.38
59_E85_K0.6770.38
19_N101_A0.6760.37
38_R41_E0.6750.37
27_L96_N0.6700.37
133_E143_K0.6640.37
26_Y84_A0.6630.36
96_N114_L0.6630.36
91_L114_L0.6600.36
33_Y37_G0.6600.36
28_E100_I0.6590.36
134_L138_A0.6500.35
64_K71_S0.6470.35
134_L147_G0.6470.35
9_R12_K0.6440.35
69_G73_L0.6430.35
24_D116_D0.6410.35
23_V149_T0.6390.35
46_Q54_Q0.6340.34
10_Q115_G0.6300.34
84_A114_L0.6300.34
42_G50_R0.6170.33
79_E83_K0.6160.33
41_E45_A0.6160.33
85_K89_K0.6140.33
63_K67_E0.6130.33
34_K135_D0.6100.32
29_N153_V0.6100.32
141_A148_K0.6070.32
150_K153_V0.6060.32
21_L102_G0.6060.32
11_L14_Q0.6040.32
42_G49_A0.6020.32
21_L29_N0.5990.31
93_A114_L0.5920.31
19_N127_W0.5920.31
10_Q95_H0.5900.31
23_V26_Y0.5880.31
151_M155_L0.5850.30
63_K66_R0.5850.30
95_H102_G0.5840.30
27_L139_E0.5830.30
54_Q85_K0.5820.30
51_K55_R0.5820.30
5_K8_D0.5820.30
83_K87_W0.5790.30
26_Y138_A0.5790.30
9_R116_D0.5790.30
51_K54_Q0.5770.30
115_G153_V0.5710.29
45_A48_A0.5700.29
17_G126_Q0.5640.29
60_A87_W0.5630.29
117_R123_I0.5550.28
55_R60_A0.5530.28
88_M91_L0.5480.28
33_Y113_G0.5470.28
55_R66_R0.5450.28
49_A112_I0.5430.27
62_Q71_S0.5420.27
62_Q65_L0.5400.27
82_K129_S0.5360.27
46_Q134_L0.5360.27
140_K143_K0.5350.27
23_V44_A0.5300.27
59_E68_L0.5290.27
134_L142_P0.5270.26
67_E77_K0.5240.26
137_A141_A0.5210.26
65_L70_K0.5190.26
11_L15_E0.5170.26
57_L64_K0.5160.26
72_G77_K0.5130.25
77_K80_A0.5120.25
18_L26_Y0.5120.25
64_K78_K0.5110.25
11_L17_G0.5090.25
23_V142_P0.5070.25
51_K77_K0.5060.25
108_K111_V0.5010.25
59_E66_R0.5010.25
24_D148_K0.5010.25
33_Y147_G0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vw1A 5 0.8397 10.1 0.945 Contact Map
4dbbA 1 0.3269 6.6 0.949 Contact Map
2da7A 1 0.2885 3.5 0.955 Contact Map
2da3A 1 0.2692 3.1 0.956 Contact Map
2dmtA 1 0.2692 3.1 0.957 Contact Map
2craA 1 0.2692 3 0.957 Contact Map
2yszA 1 0.3141 3 0.957 Contact Map
2e19A 1 0.2564 2.9 0.957 Contact Map
2da2A 1 0.2692 2.9 0.957 Contact Map
1fjlA 2 0.2692 2.8 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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