GREMLIN Database
Imm74 - Immunity protein 74
PFAM: PF15603 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 80 (72)
Sequences: 642 (524)
Seq/√Len: 61.7
META: 0.928

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_T46_D3.9551.00
58_E61_R3.6131.00
55_T58_E3.5621.00
22_G35_F3.0341.00
18_L42_I2.4391.00
21_D41_S2.0191.00
69_A72_F2.0151.00
20_I66_I1.9561.00
64_E68_E1.8651.00
49_H52_E1.7460.99
39_L60_Q1.7250.99
13_E65_N1.6670.99
70_F77_V1.5210.98
71_E77_V1.5190.98
45_W48_P1.5100.98
43_K63_L1.4650.98
47_P50_D1.3210.96
18_L54_I1.3150.96
52_E58_E1.2930.96
6_R23_E1.1790.93
57_E60_Q1.1510.92
25_L38_Y1.1340.91
44_N49_H1.1260.91
53_P78_E1.1200.91
11_V65_N1.1030.90
67_R77_V1.0920.90
71_E74_G1.0760.89
10_R46_D1.0730.89
11_V66_I1.0490.88
39_L79_F1.0470.88
35_F54_I1.0430.88
56_E60_Q1.0370.87
17_T58_E1.0330.87
57_E64_E1.0170.86
56_E59_R1.0030.85
34_D75_L0.9970.85
25_L36_V0.9870.85
17_T46_D0.9690.83
36_V70_F0.9670.83
21_D38_Y0.9460.82
12_R15_G0.9410.82
5_T10_R0.9160.80
35_F77_V0.8840.77
27_G36_V0.8700.76
29_A52_E0.8580.75
27_G34_D0.8520.75
5_T11_V0.8380.74
26_A36_V0.8360.73
28_G36_V0.8310.73
38_Y41_S0.8240.72
65_N69_A0.8190.72
44_N52_E0.8170.72
54_I58_E0.8090.71
53_P56_E0.8000.70
7_G21_D0.7970.70
63_L79_F0.7930.69
11_V62_I0.7690.67
10_R61_R0.7680.67
42_I59_R0.7600.66
5_T13_E0.7570.66
13_E25_L0.7570.66
54_I62_I0.7540.65
53_P57_E0.7510.65
61_R74_G0.7470.65
35_F42_I0.7360.64
18_L37_V0.7300.63
20_I24_M0.7270.63
41_S76_E0.7230.62
49_H53_P0.7160.61
8_A11_V0.7040.60
7_G12_R0.7030.60
60_Q64_E0.6950.59
33_P76_E0.6940.59
25_L33_P0.6860.58
5_T8_A0.6860.58
27_G46_D0.6750.57
24_M27_G0.6720.57
44_N54_I0.6450.54
59_R71_E0.6430.53
34_D72_F0.6420.53
43_K47_P0.6240.51
11_V18_L0.6180.50
39_L51_N0.6130.50
24_M29_A0.6090.49
17_T64_E0.5980.48
48_P51_N0.5970.48
61_R65_N0.5930.48
27_G37_V0.5860.47
34_D67_R0.5810.46
7_G36_V0.5760.46
10_R19_T0.5650.44
50_D75_L0.5650.44
27_G71_E0.5650.44
17_T76_E0.5600.44
5_T12_R0.5600.44
23_E43_K0.5570.44
19_T59_R0.5540.43
24_M70_F0.5480.43
68_E73_R0.5480.43
27_G62_I0.5460.42
12_R28_G0.5410.42
28_G34_D0.5290.40
18_L52_E0.5200.39
66_I69_A0.5200.39
25_L70_F0.5120.39
51_N60_Q0.5020.38
26_A64_E0.5020.38
23_E52_E0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fvtA 1 0.9125 48.4 0.843 Contact Map
3cpkA 1 0.8 46.1 0.845 Contact Map
2gm2A 1 0.9125 42.3 0.848 Contact Map
3mczA 2 0.8875 25.8 0.865 Contact Map
4ht4A 1 0.9375 23.6 0.867 Contact Map
2ab1A 1 0.8625 23.1 0.867 Contact Map
2fi9A 1 0.7875 22.5 0.869 Contact Map
2r3sA 4 0.8875 20.2 0.871 Contact Map
3dp7A 2 0.8875 17.3 0.875 Contact Map
4a6dA 2 0.85 15.5 0.878 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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