Imm74 - PFAM28P - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Imm74 - Immunity protein 74

PFAM:	PF15603	Sequences: IVELTRGAIRVREGGRTLTIDGEMLAGGAEGSPDFVVYLDSIKNWDPPHDNEPITEEERQRILENIREAFEFRGLEVEFE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	80 (72)
Sequences:	642 (524)
Seq/√Len:	61.7
META:	0.928

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
19_T	46_D	3.955	1.00
58_E	61_R	3.613	1.00
55_T	58_E	3.562	1.00
22_G	35_F	3.034	1.00
18_L	42_I	2.439	1.00
21_D	41_S	2.019	1.00
69_A	72_F	2.015	1.00
20_I	66_I	1.956	1.00
64_E	68_E	1.865	1.00
49_H	52_E	1.746	0.99
39_L	60_Q	1.725	0.99
13_E	65_N	1.667	0.99
70_F	77_V	1.521	0.98
71_E	77_V	1.519	0.98
45_W	48_P	1.510	0.98
43_K	63_L	1.465	0.98
47_P	50_D	1.321	0.96
18_L	54_I	1.315	0.96
52_E	58_E	1.293	0.96
6_R	23_E	1.179	0.93
57_E	60_Q	1.151	0.92
25_L	38_Y	1.134	0.91
44_N	49_H	1.126	0.91
53_P	78_E	1.120	0.91
11_V	65_N	1.103	0.90
67_R	77_V	1.092	0.90
71_E	74_G	1.076	0.89
10_R	46_D	1.073	0.89
11_V	66_I	1.049	0.88
39_L	79_F	1.047	0.88
35_F	54_I	1.043	0.88
56_E	60_Q	1.037	0.87
17_T	58_E	1.033	0.87
57_E	64_E	1.017	0.86
56_E	59_R	1.003	0.85
34_D	75_L	0.997	0.85
25_L	36_V	0.987	0.85
17_T	46_D	0.969	0.83
36_V	70_F	0.967	0.83
21_D	38_Y	0.946	0.82
12_R	15_G	0.941	0.82
5_T	10_R	0.916	0.80
35_F	77_V	0.884	0.77
27_G	36_V	0.870	0.76
29_A	52_E	0.858	0.75
27_G	34_D	0.852	0.75
5_T	11_V	0.838	0.74
26_A	36_V	0.836	0.73
28_G	36_V	0.831	0.73
38_Y	41_S	0.824	0.72
65_N	69_A	0.819	0.72
44_N	52_E	0.817	0.72
54_I	58_E	0.809	0.71
53_P	56_E	0.800	0.70
7_G	21_D	0.797	0.70
63_L	79_F	0.793	0.69
11_V	62_I	0.769	0.67
10_R	61_R	0.768	0.67
42_I	59_R	0.760	0.66
5_T	13_E	0.757	0.66
13_E	25_L	0.757	0.66
54_I	62_I	0.754	0.65
53_P	57_E	0.751	0.65
61_R	74_G	0.747	0.65
35_F	42_I	0.736	0.64
18_L	37_V	0.730	0.63
20_I	24_M	0.727	0.63
41_S	76_E	0.723	0.62
49_H	53_P	0.716	0.61
8_A	11_V	0.704	0.60
7_G	12_R	0.703	0.60
60_Q	64_E	0.695	0.59
33_P	76_E	0.694	0.59
25_L	33_P	0.686	0.58
5_T	8_A	0.686	0.58
27_G	46_D	0.675	0.57
24_M	27_G	0.672	0.57
44_N	54_I	0.645	0.54
59_R	71_E	0.643	0.53
34_D	72_F	0.642	0.53
43_K	47_P	0.624	0.51
11_V	18_L	0.618	0.50
39_L	51_N	0.613	0.50
24_M	29_A	0.609	0.49
17_T	64_E	0.598	0.48
48_P	51_N	0.597	0.48
61_R	65_N	0.593	0.48
27_G	37_V	0.586	0.47
34_D	67_R	0.581	0.46
7_G	36_V	0.576	0.46
10_R	19_T	0.565	0.44
50_D	75_L	0.565	0.44
27_G	71_E	0.565	0.44
17_T	76_E	0.560	0.44
5_T	12_R	0.560	0.44
23_E	43_K	0.557	0.44
19_T	59_R	0.554	0.43
24_M	70_F	0.548	0.43
68_E	73_R	0.548	0.43
27_G	62_I	0.546	0.42
12_R	28_G	0.541	0.42
28_G	34_D	0.529	0.40
18_L	52_E	0.520	0.39
66_I	69_A	0.520	0.39
25_L	70_F	0.512	0.39
51_N	60_Q	0.502	0.38
26_A	64_E	0.502	0.38
23_E	52_E	0.500	0.37

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2fvtA	1	0.9125	48.4	0.843	Contact Map
3cpkA	1	0.8	46.1	0.845	Contact Map
2gm2A	1	0.9125	42.3	0.848	Contact Map
3mczA	2	0.8875	25.8	0.865	Contact Map
4ht4A	1	0.9375	23.6	0.867	Contact Map
2ab1A	1	0.8625	23.1	0.867	Contact Map
2fi9A	1	0.7875	22.5	0.869	Contact Map
2r3sA	4	0.8875	20.2	0.871	Contact Map
3dp7A	2	0.8875	17.3	0.875	Contact Map
4a6dA	2	0.85	15.5	0.878	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0045 seconds.