GREMLIN Database
Imm70 - Immunity protein 70
PFAM: PF15601 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 131 (126)
Sequences: 628 (550)
Seq/√Len: 49.0
META: 0.861

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_F62_E3.3941.00
42_S52_E3.2151.00
35_R66_E2.8811.00
39_L63_I2.7091.00
57_L120_E2.6681.00
36_F66_E2.5661.00
62_E66_E2.5601.00
98_S101_N2.4481.00
24_A40_M2.3641.00
27_L36_F2.3121.00
97_T101_N2.2151.00
81_D84_K2.1541.00
53_A122_A2.1261.00
16_F20_F2.1241.00
57_L116_I1.8940.99
26_R74_K1.8710.99
29_P34_S1.8650.99
101_N110_D1.8460.99
48_L56_A1.8390.99
28_E33_G1.8370.99
17_H21_S1.8350.99
31_G34_S1.7920.99
57_L123_I1.7070.98
47_E128_P1.6630.98
92_I96_I1.6300.98
61_E116_I1.6080.98
23_I112_F1.5950.97
25_Y76_V1.5840.97
32_W40_M1.5660.97
105_T114_R1.5300.97
25_Y82_L1.5220.97
68_K100_S1.5180.97
24_A31_G1.4850.96
64_R116_I1.4660.96
64_R113_E1.4370.95
54_P123_I1.4330.95
38_T55_A1.4290.95
111_L115_L1.4200.95
6_I9_E1.4140.95
27_L66_E1.3900.94
121_L125_R1.2900.92
5_S9_E1.2870.92
67_L99_L1.2790.92
19_F99_L1.2690.91
10_V111_L1.2550.91
116_I123_I1.2350.90
10_V16_F1.2220.90
88_W96_I1.2110.89
119_L129_I1.1950.88
67_L70_L1.1730.88
21_S32_W1.1350.86
68_K98_S1.1000.84
8_Y107_D1.0970.84
123_I126_G1.0910.83
14_D17_H1.0720.82
65_E68_K1.0720.82
17_H78_D1.0630.82
53_A104_V1.0620.82
24_A32_W1.0580.81
17_H79_I1.0560.81
17_H32_W1.0350.80
17_H39_L1.0340.80
22_T26_R1.0120.78
109_E117_E0.9960.77
58_R94_K0.9860.77
91_N96_I0.9850.77
22_T67_L0.9760.76
26_R66_E0.9740.76
17_H24_A0.9700.75
53_A123_I0.9700.75
97_T110_D0.9570.74
37_P59_E0.9560.74
5_S8_Y0.9450.74
5_S107_D0.9440.73
88_W93_S0.9380.73
89_G92_I0.9230.72
124_E127_L0.9000.70
115_L123_I0.9000.70
28_E35_R0.8750.68
53_A119_L0.8670.67
15_F19_F0.8550.66
58_R61_E0.8520.66
127_L130_L0.8420.65
38_T59_E0.8390.64
88_W92_I0.8360.64
19_F92_I0.8340.64
45_D109_E0.8320.64
75_V86_P0.8310.64
24_A29_P0.8240.63
85_Q90_D0.8150.62
50_P126_G0.8130.62
50_P122_A0.8070.61
45_D79_I0.8000.61
78_D84_K0.7940.60
73_S90_D0.7940.60
93_S96_I0.7840.59
22_T99_L0.7830.59
64_R110_D0.7690.58
13_Y43_L0.7670.57
28_E34_S0.7600.57
53_A57_L0.7560.56
38_T52_E0.7420.55
124_E128_P0.7400.55
75_V102_Y0.7300.54
26_R76_V0.7030.51
100_S110_D0.7030.51
16_F82_L0.6930.50
92_I106_S0.6900.50
99_L103_F0.6890.50
17_H44_Y0.6680.47
24_A39_L0.6650.47
117_E120_E0.6570.46
50_P128_P0.6570.46
120_E126_G0.6540.46
25_Y79_I0.6510.46
22_T76_V0.6500.46
56_A119_L0.6460.45
14_D84_K0.6430.45
99_L119_L0.6420.45
32_W43_L0.6380.44
40_M44_Y0.6340.44
111_L117_E0.6340.44
20_F44_Y0.6300.44
51_E123_I0.6280.43
59_E103_F0.6220.43
8_Y118_L0.6220.43
18_S78_D0.6210.43
7_W80_E0.6150.42
77_W86_P0.6150.42
28_E40_M0.6140.42
96_I102_Y0.6130.42
104_V110_D0.6120.42
16_F111_L0.6110.42
44_Y102_Y0.6020.41
78_D97_T0.5990.40
89_G96_I0.5980.40
116_I120_E0.5950.40
28_E32_W0.5920.40
20_F48_L0.5850.39
49_S128_P0.5850.39
35_R62_E0.5830.39
116_I119_L0.5780.38
23_I115_L0.5770.38
55_A61_E0.5760.38
57_L119_L0.5730.38
81_D85_Q0.5710.38
120_E127_L0.5710.38
51_E61_E0.5680.37
18_S103_F0.5640.37
15_F108_G0.5640.37
28_E37_P0.5640.37
20_F43_L0.5630.37
121_L124_E0.5630.37
119_L123_I0.5590.37
21_S26_R0.5590.37
18_S76_V0.5560.36
90_D94_K0.5550.36
75_V112_F0.5540.36
77_W89_G0.5530.36
21_S77_W0.5530.36
16_F115_L0.5510.36
69_K74_K0.5500.36
5_S13_Y0.5500.36
42_S48_L0.5490.36
90_D101_N0.5470.36
6_I107_D0.5440.35
62_E98_S0.5420.35
56_A59_E0.5390.35
16_F129_I0.5370.35
35_R51_E0.5370.35
47_E98_S0.5370.35
52_E129_I0.5350.34
54_P67_L0.5330.34
53_A128_P0.5310.34
46_G115_L0.5280.34
77_W87_P0.5280.34
118_L129_I0.5270.34
24_A79_I0.5250.34
71_P111_L0.5240.33
69_K91_N0.5240.33
52_E126_G0.5180.33
96_I110_D0.5170.33
18_S21_S0.5160.33
26_R70_L0.5150.33
15_F93_S0.5100.32
34_S111_L0.5090.32
64_R100_S0.5080.32
89_G104_V0.5080.32
47_E130_L0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fnqA 4 0.9008 28 0.927 Contact Map
3mi6A 4 0.8931 25.4 0.928 Contact Map
1nbaA 4 0.5954 22.8 0.93 Contact Map
3u65B 1 0.9237 22.7 0.93 Contact Map
2yfoA 4 0.9008 21.2 0.931 Contact Map
4pytA 1 0.4733 18.9 0.932 Contact Map
2v5cA 1 0.8321 14.2 0.936 Contact Map
2v5dA 1 0.7634 14.1 0.936 Contact Map
1nowA 2 0.9237 13.4 0.937 Contact Map
3hu5A 3 0.3282 11.5 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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