GREMLIN Database
Imm63 - Immunity protein 63
PFAM: PF15599 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 83 (77)
Sequences: 967 (846)
Seq/√Len: 96.4
META: 0.874

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_R29_W3.2761.00
40_S58_L3.0031.00
43_E47_R2.8411.00
14_E17_R2.7581.00
35_T62_Q2.7471.00
61_K64_E2.5951.00
51_Q57_I2.2951.00
36_F58_L2.1381.00
20_T29_W2.1031.00
66_L77_L2.0561.00
36_F40_S2.0151.00
67_G74_A1.7671.00
63_L74_A1.7161.00
35_T66_L1.6621.00
7_V14_E1.5021.00
55_R59_F1.4541.00
5_H19_T1.4391.00
69_L73_W1.3780.99
3_G19_T1.3510.99
20_T26_L1.3350.99
42_Y61_K1.3270.99
7_V17_R1.3110.99
6_Y33_D1.3070.99
31_F69_L1.2760.99
24_D70_N1.2640.99
48_I51_Q1.2480.99
53_F58_L1.2340.99
24_D27_L1.2230.99
74_A78_E1.2200.99
50_G53_F1.1770.98
31_F62_Q1.1750.98
49_E52_D1.1560.98
35_T65_L1.1420.98
9_V15_L1.1290.98
42_Y57_I1.0980.97
49_E53_F1.0690.97
31_F35_T1.0590.96
70_N73_W1.0530.96
75_E79_A1.0250.96
39_A58_L1.0190.95
32_E77_L1.0160.95
20_T23_L1.0100.95
36_F62_Q0.9870.95
28_Y80_E0.9800.94
42_Y46_H0.9710.94
43_E46_H0.9490.93
25_E76_R0.9320.93
63_L67_G0.9230.92
41_D45_K0.8910.91
20_T25_E0.8830.91
42_Y47_R0.8650.90
8_V15_L0.8430.88
9_V13_Q0.8410.88
24_D73_W0.7770.84
57_I60_A0.7610.83
75_E78_E0.7600.83
8_V16_E0.7520.82
10_E15_L0.7520.82
5_H17_R0.7460.82
6_Y28_Y0.7460.82
71_P74_A0.7440.81
22_D25_E0.7400.81
67_G78_E0.7360.81
43_E57_I0.7330.80
44_L47_R0.7280.80
9_V30_I0.7230.80
62_Q65_L0.7210.79
9_V14_E0.7070.78
48_I57_I0.7000.77
43_E53_F0.6960.77
35_T77_L0.6940.77
63_L77_L0.6890.76
28_Y76_R0.6790.75
37_S41_D0.6550.72
32_E62_Q0.6510.72
21_T45_K0.6350.70
37_S45_K0.6310.70
27_L73_W0.6310.70
43_E52_D0.6300.70
56_R59_F0.6290.69
36_F39_A0.6160.68
3_G21_T0.6120.67
9_V17_R0.6110.67
77_L80_E0.6110.67
23_L73_W0.6030.66
62_Q66_L0.6010.66
63_L78_E0.6000.66
24_D76_R0.5940.65
31_F77_L0.5810.63
66_L74_A0.5790.63
5_H12_G0.5770.63
68_K71_P0.5750.63
72_E78_E0.5670.61
6_Y34_V0.5620.61
76_R80_E0.5610.61
45_K61_K0.5590.60
35_T39_A0.5530.60
31_F36_F0.5490.59
12_G26_L0.5450.58
46_H61_K0.5450.58
39_A65_L0.5430.58
4_Y73_W0.5370.57
35_T63_L0.5350.57
48_I79_A0.5350.57
47_R55_R0.5310.57
9_V12_G0.5310.57
47_R52_D0.5300.56
25_E50_G0.5210.55
7_V65_L0.5190.55
21_T41_D0.5120.54
34_V38_M0.5100.54
10_E43_E0.5070.53
4_Y28_Y0.5030.53
51_Q71_P0.5020.52
4_Y22_D0.5000.52
30_I33_D0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2abyA 1 0.8554 5.1 0.904 Contact Map
4q6kA 4 0.3373 3.9 0.91 Contact Map
4g55A 1 0.5542 3.5 0.912 Contact Map
1nycA 1 0.7229 2.9 0.915 Contact Map
1tviA 1 0.9277 2.8 0.916 Contact Map
4jpsB 1 0.8434 2.4 0.919 Contact Map
3hlzA 1 0.9036 2.3 0.92 Contact Map
4by6C 1 0.9398 2.2 0.921 Contact Map
2b4wA 1 0.4578 2.1 0.921 Contact Map
1w2yA 2 0.4217 1.9 0.923 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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