GREMLIN Database
Imm51 - Immunity protein 51
PFAM: PF15595 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 105 (99)
Sequences: 820 (653)
Seq/√Len: 65.6
META: 0.785

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_E64_P5.0831.00
55_E81_K3.5771.00
36_G40_D3.0601.00
59_R75_D2.9801.00
39_Y64_P2.6241.00
45_A82_F2.3531.00
98_D102_R2.1551.00
37_N67_G2.1481.00
39_Y65_E2.1391.00
62_F69_F2.1301.00
76_R80_E1.7090.99
46_R50_E1.6970.99
89_A95_L1.6740.99
45_A86_F1.5500.99
35_E40_D1.5460.99
87_K91_E1.5280.99
38_G65_E1.5020.99
60_I71_A1.5000.99
42_E46_R1.4760.98
82_F86_F1.4540.98
98_D101_S1.4300.98
25_F28_R1.3860.98
34_F40_D1.3830.98
89_A96_L1.3660.97
49_L62_F1.3260.97
96_L100_F1.2960.96
44_L96_L1.2950.96
13_V83_A1.2920.96
6_H10_S1.2900.96
83_A87_K1.2820.96
53_A85_L1.2620.96
39_Y63_D1.2620.96
5_E11_G1.2610.96
51_E103_A1.2480.96
48_F85_L1.2060.95
95_L98_D1.2060.95
25_F29_F1.2050.95
99_L103_A1.1940.94
21_K93_E1.1740.94
22_P26_G1.1490.93
50_E57_L1.1350.93
14_C17_L1.1320.93
66_A70_C1.1250.92
17_L67_G1.0860.91
56_L60_I1.0730.90
65_E68_M1.0570.90
77_E80_E1.0520.90
24_A28_R1.0460.89
93_E97_R1.0320.89
39_Y66_A1.0240.88
34_F43_S1.0170.88
86_F90_C0.9910.87
87_K92_D0.9780.86
75_D78_A0.9530.84
47_V51_E0.9520.84
87_K90_C0.9140.82
37_N65_E0.8920.80
20_Y23_E0.8890.80
6_H11_G0.8690.78
48_F82_F0.8620.78
52_K56_L0.8550.77
7_E10_S0.8430.76
47_V100_F0.8420.76
59_R78_A0.8400.76
37_N66_A0.8380.76
58_E61_E0.8300.75
53_A81_K0.8220.74
6_H12_S0.8160.74
73_S78_A0.8110.73
38_G66_A0.8070.73
22_P29_F0.8060.73
49_L57_L0.8020.73
9_G92_D0.8010.73
88_A95_L0.7890.71
9_G61_E0.7870.71
45_A99_L0.7850.71
83_A96_L0.7850.71
51_E102_R0.7820.71
29_F40_D0.7710.70
48_F86_F0.7670.69
44_L100_F0.7610.69
10_S14_C0.7550.68
45_A69_F0.7520.68
21_K49_L0.7520.68
26_G29_F0.7480.67
38_G63_D0.7430.67
40_D43_S0.7420.67
9_G14_C0.7400.66
90_C96_L0.7360.66
35_E67_G0.7240.65
40_D79_L0.7210.64
63_D66_A0.7160.64
56_L78_A0.7100.63
29_F96_L0.7080.63
57_L60_I0.7080.63
62_F87_K0.7050.63
13_V16_N0.7030.62
29_F36_G0.7020.62
9_G77_E0.7010.62
11_G17_L0.6990.62
73_S79_L0.6850.60
59_R81_K0.6680.59
22_P67_G0.6670.58
29_F44_L0.6620.58
45_A79_L0.6570.57
7_E19_D0.6570.57
39_Y68_M0.6550.57
6_H9_G0.6520.57
26_G30_E0.6480.56
28_R31_E0.6340.55
56_L87_K0.6340.55
15_L36_G0.6270.54
98_D104_E0.6200.53
44_L89_A0.6170.53
76_R88_A0.6080.52
61_E67_G0.6070.51
60_I72_Y0.6060.51
38_G41_W0.5970.50
34_F44_L0.5970.50
56_L81_K0.5820.49
29_F100_F0.5730.47
25_F97_R0.5720.47
63_D68_M0.5710.47
95_L100_F0.5700.47
32_E62_F0.5650.47
44_L99_L0.5640.46
88_A98_D0.5640.46
81_K85_L0.5590.46
10_S60_I0.5590.46
50_E55_E0.5540.45
42_E62_F0.5520.45
21_K91_E0.5500.45
17_L37_N0.5420.44
25_F36_G0.5420.44
15_L79_L0.5370.43
47_V99_L0.5370.43
53_A83_A0.5360.43
95_L101_S0.5330.43
39_Y42_E0.5310.43
47_V52_K0.5300.42
94_E101_S0.5250.42
47_V102_R0.5210.41
13_V17_L0.5200.41
32_E100_F0.5120.40
5_E76_R0.5110.40
73_S83_A0.5070.40
86_F100_F0.5030.39
12_S16_N0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1uwkA 2 0.8857 23.6 0.885 Contact Map
1x87A 2 0.8857 23.2 0.885 Contact Map
2fknA 2 0.8857 23.1 0.885 Contact Map
1ik9A 2 0.8857 10 0.903 Contact Map
1muwA 4 0.9619 7.6 0.908 Contact Map
1yprA 1 0.6095 6.5 0.911 Contact Map
1z56A 2 0.1048 6.5 0.911 Contact Map
1y2tA 4 0.8952 6.5 0.911 Contact Map
1wv8A 2 0.4952 6.1 0.912 Contact Map
2ofcA 4 0.8952 6 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0049 seconds.