GREMLIN Database
Imm50 - Immunity protein 50
PFAM: PF15594 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 118 (114)
Sequences: 1235 (1127)
Seq/√Len: 105.5
META: 0.817

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_P45_P3.7251.00
46_P49_W2.7611.00
78_V98_S2.6071.00
64_G108_K2.5401.00
41_T45_P2.4561.00
80_F98_S2.3281.00
92_R106_K2.2471.00
22_S35_R2.2421.00
19_E27_R2.1191.00
67_D106_K2.0491.00
62_F105_F2.0481.00
91_F110_I1.9661.00
5_L58_V1.9491.00
8_I56_V1.9101.00
22_S26_D1.9031.00
93_V105_F1.8821.00
65_V68_L1.8231.00
41_T44_E1.8021.00
3_E7_S1.7881.00
40_E44_E1.7841.00
40_E43_D1.7361.00
21_L57_L1.7161.00
25_L73_F1.7091.00
34_L95_L1.6701.00
84_I91_F1.6341.00
38_L58_V1.5901.00
23_L101_L1.5671.00
81_G96_E1.5571.00
22_S33_T1.5101.00
40_E45_P1.4831.00
61_R113_E1.4601.00
63_E111_E1.4581.00
20_V79_I1.4361.00
87_E92_R1.4281.00
58_V115_V1.3971.00
37_H55_H1.3581.00
25_L70_L1.3521.00
19_E76_Q1.3460.99
97_S102_S1.3450.99
24_H33_T1.2920.99
11_Y54_N1.2800.99
63_E109_S1.2590.99
73_F77_N1.2310.99
87_E106_K1.2250.99
19_E77_N1.2210.99
52_L55_H1.2150.99
74_N99_Y1.2020.99
100_G103_G1.1690.99
54_N60_L1.1580.98
45_P49_W1.1480.98
62_F93_V1.1300.98
80_F96_E1.1190.98
70_L103_G1.1190.98
8_I54_N1.1060.98
61_R111_E1.0860.98
60_L112_V1.0690.97
47_K50_Y1.0620.97
46_P50_Y1.0600.97
68_L72_G1.0580.97
27_R74_N1.0310.97
80_F95_L0.9700.95
35_R57_L0.9640.95
97_S101_L0.9510.95
74_N78_V0.9460.95
33_T61_R0.9290.94
27_R72_G0.9030.93
74_N77_N0.9010.93
92_R104_S0.8970.93
32_L36_F0.8960.93
42_P49_W0.8910.93
5_L112_V0.8910.93
79_I82_L0.8810.92
10_G15_F0.8680.92
10_G17_D0.8660.92
89_D108_K0.8650.92
93_V107_C0.8640.92
107_C110_I0.8560.91
85_E92_R0.8560.91
2_A12_W0.8510.91
79_I95_L0.8340.90
105_F113_E0.8240.90
94_E104_S0.8190.89
85_E94_E0.8090.89
11_Y40_E0.8060.89
34_L37_H0.7940.88
5_L56_V0.7820.87
19_E78_V0.7800.87
71_E96_E0.7750.87
62_F110_I0.7750.87
10_G43_D0.7690.86
41_T49_W0.7640.86
62_F107_C0.7620.86
36_F39_W0.7540.85
4_K107_C0.7390.84
16_H19_E0.7340.83
44_E51_V0.7240.83
17_D77_N0.7010.81
9_F45_P0.6970.80
72_G102_S0.6890.79
53_F65_V0.6870.79
34_L44_E0.6870.79
42_P46_P0.6800.79
27_R75_H0.6790.78
24_H32_L0.6760.78
19_E72_G0.6710.78
39_W55_H0.6690.77
18_A36_F0.6650.77
9_F48_G0.6650.77
21_L26_D0.6510.75
5_L12_W0.6490.75
18_A81_G0.6430.75
25_L76_Q0.6420.74
34_L53_F0.6380.74
27_R76_Q0.6370.74
9_F99_Y0.6350.74
31_S63_E0.6230.72
66_S108_K0.6230.72
21_L73_F0.6200.72
87_E90_G0.6150.71
36_F43_D0.6130.71
43_D46_P0.6070.70
48_G53_F0.6050.70
15_F58_V0.6020.70
67_D93_V0.6000.69
27_R77_N0.5970.69
14_S87_E0.5940.69
30_P36_F0.5910.68
84_I110_I0.5880.68
21_L27_R0.5830.67
103_G112_V0.5800.67
19_E93_V0.5800.67
105_F110_I0.5790.67
29_G64_G0.5780.67
92_R96_E0.5770.66
6_T10_G0.5690.65
4_K114_S0.5650.65
70_L101_L0.5640.65
19_E74_N0.5640.65
2_A56_V0.5640.65
83_S94_E0.5620.64
23_L74_N0.5620.64
56_V112_V0.5570.64
33_T113_E0.5530.63
66_S106_K0.5520.63
30_P35_R0.5520.63
103_G107_C0.5510.63
49_W54_N0.5500.63
9_F18_A0.5490.63
64_G109_S0.5470.62
65_V97_S0.5470.62
5_L13_P0.5460.62
73_F76_Q0.5360.61
8_I48_G0.5330.60
79_I87_E0.5300.60
67_D88_E0.5250.59
15_F82_L0.5250.59
86_K91_F0.5240.59
102_S114_S0.5230.59
7_S47_K0.5210.59
20_V103_G0.5210.59
42_P55_H0.5160.58
85_E106_K0.5150.58
39_W107_C0.5140.58
32_L73_F0.5130.58
44_E86_K0.5090.57
26_D31_S0.5080.57
83_S92_R0.5050.56
81_G90_G0.5020.56
12_W89_D0.5010.56
15_F18_A0.5000.56
6_T24_H0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lycA 2 0.9831 5.6 0.916 Contact Map
4dweA 1 0.839 4.4 0.92 Contact Map
1te0A 6 0.3729 3.6 0.923 Contact Map
2p3wA 2 0.4237 3.6 0.924 Contact Map
1fc3A 3 0.3305 3.3 0.925 Contact Map
1o22A 2 0.7119 3.1 0.926 Contact Map
4kngE 1 0.339 2.8 0.927 Contact Map
3petA 2 0.8898 2.8 0.927 Contact Map
3h7iA 1 0.8559 2.7 0.928 Contact Map
2iiiA 2 0.8814 2.6 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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