Imm50 - PFAM28P - GREMLIN Contacts

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Imm50 - Immunity protein 50

PFAM:	PF15594	Sequences: NAEKLTSIFGYWPSFHDAEVLSLHLDRDGPSLTLRFHLWETPDEPPKGWYVLFNHVLVTLRFEGVSDLELEGFNHQNVIFGLSIEKEEDGFRVELESSYGLSGSFKCKSIEVESVSPY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	118 (114)
Sequences:	1235 (1127)
Seq/√Len:	105.5
META:	0.817

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
42_P	45_P	3.725	1.00
46_P	49_W	2.761	1.00
78_V	98_S	2.607	1.00
64_G	108_K	2.540	1.00
41_T	45_P	2.456	1.00
80_F	98_S	2.328	1.00
92_R	106_K	2.247	1.00
22_S	35_R	2.242	1.00
19_E	27_R	2.119	1.00
67_D	106_K	2.049	1.00
62_F	105_F	2.048	1.00
91_F	110_I	1.966	1.00
5_L	58_V	1.949	1.00
8_I	56_V	1.910	1.00
22_S	26_D	1.903	1.00
93_V	105_F	1.882	1.00
65_V	68_L	1.823	1.00
41_T	44_E	1.802	1.00
3_E	7_S	1.788	1.00
40_E	44_E	1.784	1.00
40_E	43_D	1.736	1.00
21_L	57_L	1.716	1.00
25_L	73_F	1.709	1.00
34_L	95_L	1.670	1.00
84_I	91_F	1.634	1.00
38_L	58_V	1.590	1.00
23_L	101_L	1.567	1.00
81_G	96_E	1.557	1.00
22_S	33_T	1.510	1.00
40_E	45_P	1.483	1.00
61_R	113_E	1.460	1.00
63_E	111_E	1.458	1.00
20_V	79_I	1.436	1.00
87_E	92_R	1.428	1.00
58_V	115_V	1.397	1.00
37_H	55_H	1.358	1.00
25_L	70_L	1.352	1.00
19_E	76_Q	1.346	0.99
97_S	102_S	1.345	0.99
24_H	33_T	1.292	0.99
11_Y	54_N	1.280	0.99
63_E	109_S	1.259	0.99
73_F	77_N	1.231	0.99
87_E	106_K	1.225	0.99
19_E	77_N	1.221	0.99
52_L	55_H	1.215	0.99
74_N	99_Y	1.202	0.99
100_G	103_G	1.169	0.99
54_N	60_L	1.158	0.98
45_P	49_W	1.148	0.98
62_F	93_V	1.130	0.98
80_F	96_E	1.119	0.98
70_L	103_G	1.119	0.98
8_I	54_N	1.106	0.98
61_R	111_E	1.086	0.98
60_L	112_V	1.069	0.97
47_K	50_Y	1.062	0.97
46_P	50_Y	1.060	0.97
68_L	72_G	1.058	0.97
27_R	74_N	1.031	0.97
80_F	95_L	0.970	0.95
35_R	57_L	0.964	0.95
97_S	101_L	0.951	0.95
74_N	78_V	0.946	0.95
33_T	61_R	0.929	0.94
27_R	72_G	0.903	0.93
74_N	77_N	0.901	0.93
92_R	104_S	0.897	0.93
32_L	36_F	0.896	0.93
42_P	49_W	0.891	0.93
5_L	112_V	0.891	0.93
79_I	82_L	0.881	0.92
10_G	15_F	0.868	0.92
10_G	17_D	0.866	0.92
89_D	108_K	0.865	0.92
93_V	107_C	0.864	0.92
107_C	110_I	0.856	0.91
85_E	92_R	0.856	0.91
2_A	12_W	0.851	0.91
79_I	95_L	0.834	0.90
105_F	113_E	0.824	0.90
94_E	104_S	0.819	0.89
85_E	94_E	0.809	0.89
11_Y	40_E	0.806	0.89
34_L	37_H	0.794	0.88
5_L	56_V	0.782	0.87
19_E	78_V	0.780	0.87
71_E	96_E	0.775	0.87
62_F	110_I	0.775	0.87
10_G	43_D	0.769	0.86
41_T	49_W	0.764	0.86
62_F	107_C	0.762	0.86
36_F	39_W	0.754	0.85
4_K	107_C	0.739	0.84
16_H	19_E	0.734	0.83
44_E	51_V	0.724	0.83
17_D	77_N	0.701	0.81
9_F	45_P	0.697	0.80
72_G	102_S	0.689	0.79
53_F	65_V	0.687	0.79
34_L	44_E	0.687	0.79
42_P	46_P	0.680	0.79
27_R	75_H	0.679	0.78
24_H	32_L	0.676	0.78
19_E	72_G	0.671	0.78
39_W	55_H	0.669	0.77
18_A	36_F	0.665	0.77
9_F	48_G	0.665	0.77
21_L	26_D	0.651	0.75
5_L	12_W	0.649	0.75
18_A	81_G	0.643	0.75
25_L	76_Q	0.642	0.74
34_L	53_F	0.638	0.74
27_R	76_Q	0.637	0.74
9_F	99_Y	0.635	0.74
31_S	63_E	0.623	0.72
66_S	108_K	0.623	0.72
21_L	73_F	0.620	0.72
87_E	90_G	0.615	0.71
36_F	43_D	0.613	0.71
43_D	46_P	0.607	0.70
48_G	53_F	0.605	0.70
15_F	58_V	0.602	0.70
67_D	93_V	0.600	0.69
27_R	77_N	0.597	0.69
14_S	87_E	0.594	0.69
30_P	36_F	0.591	0.68
84_I	110_I	0.588	0.68
21_L	27_R	0.583	0.67
103_G	112_V	0.580	0.67
19_E	93_V	0.580	0.67
105_F	110_I	0.579	0.67
29_G	64_G	0.578	0.67
92_R	96_E	0.577	0.66
6_T	10_G	0.569	0.65
4_K	114_S	0.565	0.65
70_L	101_L	0.564	0.65
19_E	74_N	0.564	0.65
2_A	56_V	0.564	0.65
83_S	94_E	0.562	0.64
23_L	74_N	0.562	0.64
56_V	112_V	0.557	0.64
33_T	113_E	0.553	0.63
66_S	106_K	0.552	0.63
30_P	35_R	0.552	0.63
103_G	107_C	0.551	0.63
49_W	54_N	0.550	0.63
9_F	18_A	0.549	0.63
64_G	109_S	0.547	0.62
65_V	97_S	0.547	0.62
5_L	13_P	0.546	0.62
73_F	76_Q	0.536	0.61
8_I	48_G	0.533	0.60
79_I	87_E	0.530	0.60
67_D	88_E	0.525	0.59
15_F	82_L	0.525	0.59
86_K	91_F	0.524	0.59
102_S	114_S	0.523	0.59
7_S	47_K	0.521	0.59
20_V	103_G	0.521	0.59
42_P	55_H	0.516	0.58
85_E	106_K	0.515	0.58
39_W	107_C	0.514	0.58
32_L	73_F	0.513	0.58
44_E	86_K	0.509	0.57
26_D	31_S	0.508	0.57
83_S	92_R	0.505	0.56
81_G	90_G	0.502	0.56
12_W	89_D	0.501	0.56
15_F	18_A	0.500	0.56
6_T	24_H	0.500	0.56

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3lycA	2	0.9831	5.6	0.916	Contact Map
4dweA	1	0.839	4.4	0.92	Contact Map
1te0A	6	0.3729	3.6	0.923	Contact Map
2p3wA	2	0.4237	3.6	0.924	Contact Map
1fc3A	3	0.3305	3.3	0.925	Contact Map
1o22A	2	0.7119	3.1	0.926	Contact Map
4kngE	1	0.339	2.8	0.927	Contact Map
3petA	2	0.8898	2.8	0.927	Contact Map
3h7iA	1	0.8559	2.7	0.928	Contact Map
2iiiA	2	0.8814	2.6	0.929	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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