GREMLIN Database
Imm42 - Immunity protein 42
PFAM: PF15593 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 161 (157)
Sequences: 567 (523)
Seq/√Len: 41.8
META: 0.762

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
130_R143_E5.1541.00
74_D77_E3.1871.00
6_P10_A3.1301.00
106_F109_S3.0381.00
12_E32_W3.0251.00
75_A143_E2.4071.00
150_E154_V2.4041.00
1_M4_G2.3591.00
8_K150_E2.2541.00
88_F93_F2.2531.00
37_R41_R2.1891.00
6_P19_W2.1320.99
29_F33_I2.1120.99
124_D129_V2.0680.99
146_L151_F1.9830.99
12_E39_G1.9820.99
88_F95_E1.9640.99
129_V149_G1.9500.99
133_W136_D1.9400.99
33_I55_V1.9200.99
147_P150_E1.8510.98
112_E115_D1.8420.98
103_N106_F1.7980.98
16_V19_W1.7490.98
87_Y93_F1.7440.98
32_W37_R1.7320.97
4_G10_A1.7300.97
153_S157_E1.7000.97
39_G114_F1.6540.97
49_A53_D1.6430.97
24_W48_L1.6410.97
146_L155_L1.6370.96
134_S138_D1.6140.96
125_N145_W1.5570.95
86_F93_F1.5100.94
152_Y155_L1.4820.94
36_R142_S1.4610.93
9_F131_L1.4500.93
11_I153_S1.4390.93
27_G46_T1.4350.93
135_D139_P1.4330.93
40_D45_A1.4310.93
33_I123_V1.4230.92
61_L101_E1.4210.92
100_Y104_Y1.4030.92
32_W39_G1.4030.92
31_I55_V1.3980.92
5_D35_G1.3650.91
67_D70_L1.3470.90
136_D140_T1.3190.89
45_A112_E1.3080.89
87_Y90_G1.2900.88
71_F125_N1.2830.88
19_W26_L1.2780.88
141_I145_W1.2640.87
59_I63_G1.2600.87
12_E114_F1.2570.87
39_G124_D1.2310.86
1_M5_D1.2140.85
36_R156_E1.2020.84
79_F82_L1.2010.84
83_Y119_Y1.1960.84
11_I72_E1.1820.83
48_L152_Y1.1780.83
5_D8_K1.1680.82
45_A119_Y1.1660.82
136_D139_P1.1650.82
90_G93_F1.1330.80
78_I130_R1.1310.80
21_D24_W1.1310.80
23_S47_L1.1260.80
89_P96_L1.1170.80
100_Y103_N1.1130.79
82_L119_Y1.1110.79
11_I155_L1.1070.79
137_D140_T1.0950.78
29_F50_C1.0870.78
87_Y91_D1.0840.77
149_G154_V1.0810.77
133_W139_P1.0510.75
15_I25_A1.0460.75
34_G144_V1.0130.72
76_E80_D1.0110.72
17_E94_D0.9600.68
28_F39_G0.9550.68
128_R145_W0.9350.66
130_R145_W0.9250.65
68_P146_L0.9160.65
89_P92_D0.9140.64
31_I129_V0.9020.63
4_G9_F0.8800.61
55_V155_L0.8750.61
32_W40_D0.8720.61
146_L150_E0.8660.60
105_R108_I0.8660.60
150_E153_S0.8610.60
149_G153_S0.8610.60
128_R147_P0.8580.60
82_L105_R0.8450.58
86_F90_G0.8440.58
107_D110_G0.8430.58
8_K77_E0.8410.58
10_A132_I0.8370.58
126_G141_I0.8320.57
38_Y46_T0.8280.57
87_Y97_D0.8260.57
134_S139_P0.8220.56
26_L121_F0.8110.55
30_V37_R0.8090.55
69_F81_A0.8060.55
5_D141_I0.8060.55
90_G95_E0.8030.54
34_G38_Y0.7990.54
73_L105_R0.7960.54
80_D135_D0.7950.54
10_A127_D0.7940.54
152_Y156_E0.7930.54
2_I150_E0.7930.54
24_W53_D0.7890.53
93_F97_D0.7810.52
129_V152_Y0.7800.52
2_I5_D0.7760.52
129_V146_L0.7740.52
102_S109_S0.7730.52
111_D114_F0.7690.51
79_F141_I0.7490.49
78_I132_I0.7490.49
110_G115_D0.7410.49
2_I56_D0.7380.48
129_V132_I0.7320.48
42_E140_T0.7310.48
144_V153_S0.7230.47
102_S108_I0.7200.47
1_M100_Y0.7200.47
26_L114_F0.7150.46
30_V112_E0.7150.46
7_S16_V0.7130.46
69_F77_E0.7050.45
28_F50_C0.7030.45
111_D120_V0.6970.45
77_E148_A0.6910.44
42_E147_P0.6870.44
87_Y95_E0.6870.44
110_G113_A0.6850.43
33_I38_Y0.6810.43
45_A113_A0.6760.43
99_D102_S0.6730.42
31_I108_I0.6720.42
94_D154_V0.6670.42
153_S156_E0.6640.42
9_F154_V0.6640.42
3_I13_S0.6630.41
89_P95_E0.6610.41
1_M14_E0.6560.41
33_I135_D0.6560.41
151_F154_V0.6550.41
14_E28_F0.6430.40
27_G106_F0.6430.40
101_E104_Y0.6400.39
87_Y96_L0.6380.39
92_D95_E0.6380.39
90_G98_E0.6370.39
133_W137_D0.6330.39
122_L129_V0.6330.39
61_L67_D0.6320.39
61_L65_H0.6260.38
11_I126_G0.6260.38
86_F89_P0.6250.38
29_F110_G0.6250.38
43_P154_V0.6200.38
8_K47_L0.6180.37
106_F110_G0.6170.37
45_A111_D0.6150.37
25_A29_F0.6140.37
1_M37_R0.6120.37
34_G142_S0.6100.37
68_P74_D0.6100.37
76_E98_E0.5850.35
117_G127_D0.5850.35
114_F151_F0.5840.34
2_I6_P0.5780.34
56_D93_F0.5780.34
38_Y79_F0.5760.34
82_L121_F0.5740.34
5_D19_W0.5710.33
5_D20_E0.5690.33
131_L155_L0.5680.33
31_I52_F0.5680.33
76_E99_D0.5670.33
24_W46_T0.5650.33
126_G146_L0.5610.33
25_A48_L0.5590.32
17_E23_S0.5570.32
61_L64_K0.5560.32
26_L39_G0.5560.32
30_V39_G0.5560.32
54_L155_L0.5560.32
50_C110_G0.5500.32
58_R67_D0.5500.32
9_F31_I0.5460.31
91_D95_E0.5420.31
12_E30_V0.5420.31
96_L104_Y0.5390.31
70_L80_D0.5380.31
15_I29_F0.5380.31
92_D97_D0.5360.31
90_G137_D0.5340.30
32_W122_L0.5340.30
48_L52_F0.5330.30
4_G35_G0.5330.30
64_K102_S0.5320.30
127_D131_L0.5320.30
96_L99_D0.5310.30
45_A132_I0.5300.30
76_E83_Y0.5220.29
139_P156_E0.5180.29
108_I129_V0.5170.29
15_I18_A0.5150.29
73_L78_I0.5120.29
6_P16_V0.5120.29
21_D38_Y0.5120.29
3_I18_A0.5120.29
28_F54_L0.5110.29
79_F139_P0.5100.29
88_F97_D0.5100.29
51_S55_V0.5090.28
8_K36_R0.5070.28
23_S49_A0.5070.28
7_S34_G0.5060.28
22_S45_A0.5050.28
16_V47_L0.5050.28
6_P32_W0.5020.28
7_S12_E0.5010.28
73_L77_E0.5010.28
3_I60_A0.5010.28
45_A72_E0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ayzA 1 0.5963 2.8 0.942 Contact Map
3oakC 1 0.1056 2 0.946 Contact Map
2b86A 1 0.236 1.9 0.947 Contact Map
4ak2A 1 0.354 1.3 0.951 Contact Map
1nm7A 1 0.2112 1.3 0.951 Contact Map
3bpqA 2 0.118 1.3 0.952 Contact Map
4khbA 1 0.5031 1.2 0.952 Contact Map
1lucB 1 0.3106 1.2 0.953 Contact Map
2m1mA 1 0.2236 1.2 0.953 Contact Map
2q0vA 1 0.4534 1.2 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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