GREMLIN Database
Imm27 - Immunity protein 27
PFAM: PF15590 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 74 (66)
Sequences: 798 (671)
Seq/√Len: 82.5
META: 0.969

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_C58_P3.3201.00
49_Q52_M3.0451.00
14_Y38_R2.8281.00
16_E35_R2.8011.00
44_E72_Y2.5511.00
31_E71_K2.5031.00
17_K32_T2.4651.00
9_W13_N2.2231.00
31_E46_T2.0471.00
30_W50_S1.9931.00
41_R62_V1.8831.00
17_K20_T1.8201.00
36_D39_D1.6751.00
34_Y45_L1.6421.00
27_S31_E1.4880.99
30_W47_Y1.4070.99
11_I14_Y1.4010.99
64_S67_E1.3670.99
9_W14_Y1.2850.98
26_D29_G1.2490.98
36_D41_R1.2020.97
65_A69_R1.1860.97
30_W54_G1.1430.96
52_M57_P1.1210.96
4_C59_R1.1070.96
33_L44_E1.1000.95
6_R10_L1.0990.95
35_R42_Y1.0870.95
44_E71_K1.0830.95
15_L41_R1.0770.95
47_Y58_P1.0550.94
11_I34_Y1.0490.94
18_I42_Y1.0040.93
48_P59_R1.0000.92
30_W53_H0.9360.90
32_T45_L0.9160.89
63_L71_K0.8750.86
63_L67_E0.8680.86
33_L68_A0.8630.85
4_C13_N0.8580.85
6_R41_R0.8490.85
26_D31_E0.8010.81
29_G60_L0.7830.79
6_R37_P0.7720.78
49_Q57_P0.7670.78
12_S61_R0.7620.78
14_Y37_P0.7580.77
4_C8_E0.7540.77
5_E61_R0.7440.76
8_E12_S0.7420.76
20_T32_T0.7370.75
50_S53_H0.7360.75
46_T61_R0.7350.75
49_Q62_V0.7320.75
8_E58_P0.7220.74
46_T59_R0.7210.74
9_W32_T0.7210.74
17_K47_Y0.7050.72
6_R9_W0.7000.71
9_W38_R0.6970.71
35_R65_A0.6850.70
33_L39_D0.6740.69
70_A73_G0.6560.66
30_W48_P0.6320.64
13_N16_E0.6280.63
44_E61_R0.6220.62
42_Y62_V0.6170.62
47_Y50_S0.6130.61
66_E70_A0.6060.60
65_A73_G0.6060.60
10_L39_D0.6050.60
10_L15_L0.6010.60
5_E66_E0.6000.60
15_L36_D0.6000.60
20_T28_G0.5900.58
55_G64_S0.5900.58
49_Q58_P0.5900.58
28_G31_E0.5880.58
67_E70_A0.5840.58
16_E62_V0.5810.57
26_D58_P0.5810.57
7_I54_G0.5770.57
30_W55_G0.5710.56
47_Y53_H0.5660.55
6_R36_D0.5630.55
51_E55_G0.5470.53
13_N59_R0.5400.52
5_E8_E0.5370.51
32_T47_Y0.5330.51
35_R40_G0.5320.51
68_A72_Y0.5270.50
33_L72_Y0.5260.50
50_S54_G0.5250.50
11_I18_I0.5140.48
42_Y65_A0.5130.48
50_S55_G0.5090.48
45_L58_P0.5090.48
62_V65_A0.5020.47
18_I35_R0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kjzA 2 0.6351 35.9 0.891 Contact Map
3sk2A 2 0.6216 28.2 0.897 Contact Map
4nvsA 2 0.9054 27 0.898 Contact Map
3kolA 2 0.6216 24.3 0.9 Contact Map
4g6xA 2 0.6081 21.3 0.903 Contact Map
3ct8A 2 0.6216 21.3 0.903 Contact Map
2vpqA 2 0.9054 19.2 0.905 Contact Map
3omsA 2 0.6081 17.7 0.907 Contact Map
4pavA 9 0.6081 17.3 0.907 Contact Map
1gk8I 3 0.7838 15.3 0.909 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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