GREMLIN Database
Imm10 - Immunity protein 10
PFAM: PF15588 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 105 (97)
Sequences: 637 (541)
Seq/√Len: 54.9
META: 0.772

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_D28_G3.3211.00
22_D27_P3.1491.00
62_G84_A3.1341.00
62_G65_G3.0131.00
20_F97_F2.8091.00
19_G32_I2.7831.00
42_Q46_L2.7061.00
54_E58_Q2.4261.00
42_Q47_G2.2141.00
70_E77_R1.9851.00
30_Y61_S1.8600.99
67_E79_E1.8510.99
29_R56_N1.7750.99
42_Q48_M1.7240.99
67_E81_D1.6160.98
44_V49_D1.5780.98
30_Y54_E1.5350.98
80_L93_I1.5320.98
58_Q61_S1.4580.97
31_L47_G1.4460.97
42_Q49_D1.4240.96
20_F76_L1.4130.96
15_V37_L1.3950.96
41_E45_A1.3720.96
22_D25_D1.3540.95
12_D93_I1.3110.94
4_A8_E1.3000.94
62_G88_L1.2960.94
54_E62_G1.2780.94
35_R39_F1.2680.93
55_V58_Q1.2660.93
54_E80_L1.2650.93
77_R94_E1.2510.93
30_Y56_N1.2480.93
96_T100_D1.2380.92
29_R57_D1.2000.91
71_L78_V1.1630.90
75_R94_E1.1530.90
56_N60_A1.1400.89
81_D84_A1.1320.89
39_F48_M1.1290.89
17_V66_I1.1240.88
23_D28_G1.1200.88
89_G98_D1.1110.88
61_S76_L1.1070.88
36_A39_F1.1040.87
73_R80_L1.0870.87
22_D26_G1.0650.85
69_V76_L1.0630.85
86_E96_T1.0540.85
39_F92_G1.0470.84
11_E37_L1.0460.84
39_F43_D0.9690.80
54_E61_S0.9680.79
19_G30_Y0.9560.79
40_D50_T0.9490.78
44_V48_M0.9400.77
85_A91_D0.9180.76
56_N61_S0.9160.76
49_D83_E0.9000.74
11_E16_L0.8940.74
32_I69_V0.8560.70
34_Q57_D0.8480.70
16_L37_L0.8460.70
40_D77_R0.8380.69
18_V39_F0.8300.68
33_L69_V0.8290.68
56_N92_G0.8060.66
17_V32_I0.7880.64
30_Y66_I0.7840.64
59_G87_R0.7780.63
34_Q52_Y0.7700.62
34_Q61_S0.7660.62
38_E43_D0.7630.62
82_P93_I0.7580.61
65_G80_L0.7520.60
4_A7_V0.7430.59
18_V92_G0.7350.59
47_G85_A0.7270.58
76_L97_F0.7240.58
10_D13_D0.7220.57
73_R100_D0.7200.57
34_Q43_D0.7160.57
72_S75_R0.7130.56
20_F53_C0.7120.56
66_I69_V0.7100.56
40_D48_M0.7090.56
50_T66_I0.7030.55
35_R51_Y0.6990.55
20_F92_G0.6990.55
15_V23_D0.6970.55
72_S79_E0.6970.55
31_L63_Y0.6910.54
41_E46_L0.6900.54
53_C80_L0.6890.54
69_V78_V0.6750.52
5_A8_E0.6740.52
63_Y78_V0.6590.51
53_C59_G0.6580.50
25_D77_R0.6580.50
25_D28_G0.6510.50
33_L55_V0.6500.50
51_Y65_G0.6370.48
31_L73_R0.6320.48
57_D90_L0.6310.48
11_E70_E0.6300.47
39_F50_T0.6300.47
12_D36_A0.6220.47
34_Q70_E0.6190.46
52_Y61_S0.6110.45
26_G83_E0.6100.45
10_D14_D0.6070.45
50_T64_G0.6030.45
59_G68_S0.6010.44
26_G79_E0.6010.44
77_R91_D0.5980.44
54_E66_I0.5930.44
28_G99_L0.5890.43
8_E12_D0.5860.43
39_F49_D0.5840.43
60_A88_L0.5820.42
23_D95_V0.5760.42
46_L74_D0.5720.41
70_E93_I0.5710.41
39_F69_V0.5670.41
82_P94_E0.5660.41
43_D63_Y0.5660.41
38_E76_L0.5540.39
18_V78_V0.5540.39
53_C61_S0.5470.39
53_C66_I0.5470.39
92_G95_V0.5390.38
5_A9_V0.5370.38
8_E11_E0.5340.37
16_L51_Y0.5310.37
43_D47_G0.5310.37
31_L64_G0.5310.37
44_V47_G0.5300.37
19_G27_P0.5260.37
92_G99_L0.5220.36
41_E44_V0.5180.36
20_F59_G0.5110.35
27_P52_Y0.5110.35
31_L53_C0.5100.35
24_E33_L0.5060.35
12_D24_E0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4htiA 1 0.5238 4.6 0.921 Contact Map
2jn9A 1 0.3619 3.1 0.927 Contact Map
3t4rA 1 0.3619 3 0.928 Contact Map
2l55A 1 0.4286 2.7 0.929 Contact Map
3nreA 1 0.3905 1.9 0.935 Contact Map
3nqkA 2 0.5143 1.8 0.936 Contact Map
4besA 2 0.6762 1.7 0.936 Contact Map
3os7A 2 0.5143 1.7 0.937 Contact Map
4kmqA 1 0.9524 1.7 0.937 Contact Map
4av2A 3 0 1.7 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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