GREMLIN Database
Imm8 - Immunity protein 8
PFAM: PF15586 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 114 (112)
Sequences: 1356 (1203)
Seq/√Len: 113.7
META: 0.872

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_D56_R3.1961.00
81_E85_E2.8531.00
32_M43_S2.5891.00
49_C53_W2.5671.00
93_G99_V2.5351.00
32_M41_E2.4331.00
31_A46_F2.4281.00
3_L31_A2.3501.00
95_T98_E2.3371.00
87_L106_Y2.2911.00
30_Q45_D2.1971.00
30_Q43_S2.1661.00
93_G102_K2.0611.00
50_T72_V2.0031.00
66_G71_I1.8861.00
91_C99_V1.8811.00
52_K55_A1.8221.00
9_P28_L1.8091.00
93_G98_E1.7711.00
103_L107_G1.7431.00
105_R113_D1.7351.00
25_F50_T1.6691.00
44_F96_W1.6501.00
54_L71_I1.5721.00
9_P30_Q1.5501.00
8_S11_V1.5431.00
31_A107_G1.5411.00
26_G47_T1.5391.00
28_L47_T1.5371.00
28_L45_D1.5181.00
35_P38_E1.5141.00
72_V80_I1.5001.00
97_E101_E1.4201.00
88_V103_L1.3961.00
96_W100_A1.3671.00
3_L6_L1.3221.00
3_L88_V1.3181.00
58_L73_D1.3121.00
25_F75_Y1.2970.99
111_F114_Y1.2970.99
7_H30_Q1.2900.99
13_D16_S1.2770.99
85_E89_E1.2590.99
99_V103_L1.2520.99
33_I88_V1.2490.99
24_D50_T1.2080.99
65_W83_A1.2000.99
35_P42_E1.1530.99
100_A109_W1.1220.99
63_I83_A1.0860.98
67_R112_E1.0830.98
23_E52_K1.0620.98
19_P77_W1.0400.98
105_R112_E1.0370.98
53_W57_R1.0310.97
26_G53_W1.0190.97
33_I103_L1.0150.97
66_G69_Y1.0020.97
14_L29_L0.9990.97
46_F70_L0.9710.96
100_A104_S0.9680.96
77_W81_E0.9600.96
31_A88_V0.9420.96
94_D98_E0.9380.95
67_R105_R0.9220.95
64_V71_I0.9120.95
29_L48_V0.9080.95
19_P25_F0.9060.95
86_K89_E0.8980.94
32_M42_E0.8970.94
11_V27_F0.8900.94
15_E81_E0.8900.94
24_D53_W0.8710.93
91_C103_L0.8660.93
104_S112_E0.8650.93
25_F80_I0.8630.93
47_T69_Y0.8540.93
7_H11_V0.8530.93
67_R113_D0.8350.92
19_P75_Y0.8060.90
29_L46_F0.8000.90
82_R86_K0.7980.90
34_G42_E0.7840.89
25_F77_W0.7820.89
88_V109_W0.7790.89
24_D52_K0.7670.88
87_L91_C0.7630.88
45_D108_H0.7470.87
79_A82_R0.7470.87
46_F106_Y0.7440.86
102_K113_D0.7440.86
32_M45_D0.7390.86
27_F75_Y0.7220.85
65_W70_L0.7210.85
19_P50_T0.7000.83
58_L62_G0.6870.82
87_L90_S0.6860.82
78_E90_S0.6860.82
98_E102_K0.6850.82
68_H104_S0.6730.80
62_G73_D0.6720.80
83_A87_L0.6670.80
35_P99_V0.6640.80
7_H32_M0.6580.79
88_V93_G0.6540.79
82_R85_E0.6500.78
17_Y25_F0.6480.78
36_E85_E0.6290.76
28_L46_F0.6260.75
50_T75_Y0.6250.75
21_D24_D0.6220.75
26_G49_C0.6120.74
25_F49_C0.6120.74
78_E82_R0.6100.74
7_H10_D0.6100.74
96_W99_V0.6100.74
3_L57_R0.6030.73
102_K105_R0.5980.72
49_C69_Y0.5960.72
68_H108_H0.5960.72
27_F48_V0.5930.71
51_P73_D0.5900.71
44_F100_A0.5850.70
8_S77_W0.5830.70
99_V107_G0.5800.70
7_H12_D0.5790.70
75_Y80_I0.5780.70
11_V17_Y0.5770.69
57_R62_G0.5760.69
83_A106_Y0.5720.69
71_I113_D0.5720.69
16_S20_E0.5680.68
3_L33_I0.5660.68
80_I83_A0.5550.66
78_E86_K0.5520.66
5_S15_E0.5500.66
55_A73_D0.5490.66
33_I83_A0.5480.66
17_Y69_Y0.5460.65
33_I50_T0.5450.65
65_W107_G0.5440.65
14_L77_W0.5430.65
42_E96_W0.5420.65
107_G112_E0.5410.65
15_E35_P0.5400.64
79_A95_T0.5380.64
29_L60_K0.5360.64
6_L81_E0.5350.64
56_R79_A0.5350.64
86_K90_S0.5330.63
6_L31_A0.5290.63
11_V15_E0.5280.63
65_W87_L0.5260.62
4_K7_H0.5210.62
21_D52_K0.5150.61
63_I79_A0.5140.61
68_H107_G0.5120.60
7_H43_S0.5110.60
70_L107_G0.5110.60
77_W80_I0.5110.60
35_P40_G0.5100.60
67_R104_S0.5100.60
26_G75_Y0.5090.60
58_L71_I0.5060.59
53_W68_H0.5050.59
5_S16_S0.5020.59
11_V14_L0.5010.59
58_L69_Y0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cg8A 4 0.7281 4.3 0.93 Contact Map
2a15A 2 0.3421 4.2 0.931 Contact Map
2axqA 2 0.8596 4 0.932 Contact Map
4px9A 1 0.9298 3.7 0.933 Contact Map
3lduA 1 0.6053 3.5 0.933 Contact Map
4aeyA 3 0.6491 3.1 0.935 Contact Map
4ypjA 1 0.5526 3.1 0.935 Contact Map
3jstA 1 0.3246 3 0.936 Contact Map
4bujB 1 0.3509 2.8 0.937 Contact Map
1idpA 3 0.3947 2.7 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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