GREMLIN Database
Imm53 - Immunity protein 53
PFAM: PF15580 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 91 (90)
Sequences: 2056 (1819)
Seq/√Len: 191.7
META: 0.914

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_W87_L3.9941.00
74_G82_I3.4581.00
75_G78_N2.6941.00
72_G82_I2.6741.00
59_D78_N2.5381.00
35_K69_K2.3701.00
43_L90_A2.1701.00
48_F63_C2.0311.00
64_R71_E1.9381.00
78_N81_E1.8601.00
20_Y37_D1.8201.00
33_S73_A1.8031.00
66_E71_E1.6811.00
50_E64_R1.6701.00
35_K73_A1.6291.00
9_A77_L1.6201.00
11_Q42_E1.6121.00
4_L83_L1.5641.00
37_D69_K1.5301.00
23_K35_K1.5161.00
34_V82_I1.4701.00
84_E88_D1.4621.00
61_L81_E1.4371.00
55_R59_D1.4281.00
24_I34_V1.4041.00
55_R78_N1.3601.00
45_G68_G1.3441.00
35_K71_E1.3401.00
13_D17_E1.3301.00
50_E62_H1.2411.00
39_A68_G1.2331.00
25_E33_S1.2301.00
55_R81_E1.2281.00
18_H29_N1.2171.00
63_C72_G1.2151.00
53_I81_E1.2061.00
44_E68_G1.2021.00
52_K62_H1.1891.00
53_I61_L1.1841.00
7_W11_Q1.1761.00
6_N77_L1.1711.00
14_G17_E1.0781.00
87_L90_A1.0761.00
70_F86_F1.0681.00
80_E84_E1.0441.00
8_Y12_C1.0371.00
27_L33_S1.0171.00
75_G81_E0.9981.00
63_C85_I0.9700.99
64_R73_A0.9620.99
18_H28_D0.9530.99
7_W36_I0.9270.99
22_I32_W0.9250.99
46_R89_W0.9200.99
51_V63_C0.9180.99
2_E5_Q0.9140.99
34_V83_L0.9080.99
62_H73_A0.8790.99
74_G78_N0.8580.99
38_L41_T0.8460.98
22_I36_I0.8380.98
36_I86_F0.8320.98
6_N10_S0.8300.98
43_L46_R0.8300.98
63_C89_W0.8300.98
39_A44_E0.8280.98
56_S78_N0.8170.98
48_F89_W0.8010.98
48_F85_I0.8010.98
33_S71_E0.7990.98
12_C16_W0.7840.97
2_E80_E0.7510.97
5_Q80_E0.7500.97
19_S40_G0.7460.96
27_L73_A0.7460.96
20_Y39_A0.7380.96
55_R75_G0.7280.96
61_L85_I0.7250.96
85_I88_D0.7190.96
13_D16_W0.7160.95
2_E6_N0.6960.95
7_W22_I0.6870.94
23_K69_K0.6850.94
12_C17_E0.6790.94
5_Q79_L0.6740.94
41_T45_G0.6470.92
18_H21_G0.6460.92
8_Y16_W0.6450.92
34_V70_F0.6450.92
63_C70_F0.6410.92
32_W79_L0.6400.92
85_I89_W0.6270.91
61_L82_I0.6210.91
29_N73_A0.6180.91
59_D81_E0.6180.91
51_V89_W0.6100.90
56_S59_D0.6090.90
55_R61_L0.6050.90
8_Y27_L0.6030.89
15_D19_S0.6030.89
48_F51_V0.6010.89
8_Y76_P0.5940.89
43_L48_F0.5940.89
23_K37_D0.5830.88
15_D40_G0.5810.88
11_Q40_G0.5780.87
20_Y26_T0.5770.87
80_E87_L0.5760.87
52_K64_R0.5750.87
53_I59_D0.5730.87
2_E9_A0.5690.87
21_G37_D0.5670.86
81_E85_I0.5660.86
27_L30_P0.5560.85
1_L80_E0.5510.85
84_E87_L0.5440.84
34_V79_L0.5430.84
48_F65_V0.5390.84
3_W88_D0.5360.83
3_W6_N0.5350.83
50_E66_E0.5330.83
65_V89_W0.5310.83
58_D88_D0.5290.82
46_R70_F0.5260.82
78_N83_L0.5180.81
5_Q59_D0.5180.81
22_I25_E0.5140.81
11_Q34_V0.5130.80
32_W75_G0.5080.80
74_G79_L0.5070.80
53_I78_N0.5070.80
41_T86_F0.5050.79
11_Q36_I0.5030.79
59_D75_G0.5020.79
51_V85_I0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2m0jB 1 0.2637 7.9 0.924 Contact Map
2gw6A 2 0.3956 7.1 0.925 Contact Map
1x9mA 1 0.5385 5.6 0.929 Contact Map
1j5uA 1 0.6484 3.8 0.934 Contact Map
4ab7A 3 0.4945 3.7 0.935 Contact Map
3uw2A 1 0.6923 3.2 0.936 Contact Map
3encA 2 0.6593 3.1 0.937 Contact Map
4j8cA 2 0.1978 2.8 0.938 Contact Map
4es1A 2 0.6374 2.7 0.939 Contact Map
1gaiA 1 0.8681 2.5 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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