Imm49 - PFAM28P - GREMLIN Contacts

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Imm49 - Immunity protein 49

PFAM:	PF15575	Sequences: DPDAAKFKTWEALVAALQAGSALFAAATAPTEVECNGEERTLPATGPESYADAGNWLDAFYLALISRDRERLDRLAQVPLELLRESGAEPDEYDYAWVDALQAYLLGRPGLVEKLVAALEASDPDARIAPRDLLLKLLYPPLELLRALLRGDEEAFNEALAEALELHKAYWTADERRDGDPEGLLALGPLALACLAYDRGFPIEVESDYLPKELL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	215 (209)
Sequences:	845 (685)
Seq/√Len:	47.4
META:	0.373

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
152_D	155_A	5.440	1.00
67_R	198_D	5.339	1.00
186_A	189_P	4.306	1.00
31_T	34_E	3.221	1.00
157_N	204_E	2.864	1.00
31_T	35_C	2.705	1.00
167_H	186_A	2.644	1.00
32_E	35_C	2.580	1.00
67_R	194_C	2.534	1.00
100_A	118_A	2.481	1.00
163_A	189_P	2.443	1.00
157_N	203_I	2.407	1.00
18_Q	24_F	2.342	1.00
167_H	171_W	2.323	1.00
160_L	193_A	2.250	1.00
153_E	157_N	2.229	1.00
161_A	165_E	2.069	1.00
36_N	39_E	2.044	1.00
37_G	44_A	1.981	0.99
156_F	160_L	1.896	0.99
193_A	203_I	1.834	0.99
194_C	198_D	1.827	0.99
18_Q	22_A	1.803	0.99
162_E	165_E	1.780	0.99
161_A	205_V	1.712	0.98
56_W	59_A	1.688	0.98
11_E	14_V	1.679	0.98
56_W	60_F	1.676	0.98
144_L	189_P	1.674	0.98
68_D	71_R	1.661	0.98
171_W	183_G	1.652	0.98
16_A	24_F	1.644	0.98
66_S	194_C	1.623	0.97
174_D	177_R	1.590	0.97
39_E	44_A	1.548	0.97
36_N	40_R	1.542	0.97
54_G	58_D	1.541	0.97
11_E	16_A	1.539	0.97
193_A	215_L	1.534	0.96
96_A	121_A	1.526	0.96
14_V	17_L	1.503	0.96
96_A	114_K	1.503	0.96
37_G	40_R	1.497	0.96
211_P	214_L	1.496	0.96
99_D	103_A	1.487	0.96
100_A	103_A	1.448	0.95
160_L	210_L	1.447	0.95
10_W	13_L	1.424	0.95
82_L	86_S	1.407	0.94
48_E	51_A	1.406	0.94
80_L	102_Q	1.399	0.94
60_F	160_L	1.396	0.94
101_L	106_L	1.387	0.94
12_A	17_L	1.386	0.94
39_E	43_P	1.375	0.94
163_A	167_H	1.369	0.93
143_E	162_E	1.363	0.93
98_V	102_Q	1.358	0.93
93_Y	100_A	1.350	0.93
103_A	114_K	1.343	0.93
153_E	201_F	1.328	0.92
110_G	113_E	1.320	0.92
164_L	207_S	1.304	0.92
16_A	22_A	1.303	0.92
16_A	20_G	1.280	0.91
104_Y	148_L	1.277	0.91
163_A	171_W	1.271	0.90
41_T	44_A	1.255	0.90
133_L	137_L	1.248	0.90
7_F	13_L	1.247	0.90
173_A	177_R	1.242	0.89
197_Y	215_L	1.240	0.89
165_E	168_K	1.220	0.89
163_A	170_Y	1.203	0.88
163_A	186_A	1.202	0.88
160_L	205_V	1.193	0.87
65_I	194_C	1.186	0.87
183_G	209_Y	1.181	0.87
34_E	41_T	1.181	0.87
64_L	191_A	1.179	0.87
32_E	37_G	1.139	0.85
29_A	34_E	1.133	0.85
9_T	12_A	1.131	0.84
195_L	199_R	1.128	0.84
34_E	39_E	1.117	0.84
19_A	214_L	1.107	0.83
206_E	212_K	1.103	0.83
56_W	186_A	1.096	0.83
164_L	196_A	1.088	0.82
26_A	29_A	1.083	0.82
16_A	23_L	1.079	0.82
135_L	155_A	1.078	0.82
164_L	205_V	1.078	0.82
11_E	18_Q	1.070	0.81
12_A	16_A	1.062	0.81
34_E	43_P	1.061	0.80
9_T	13_L	1.051	0.80
99_D	114_K	1.041	0.79
70_E	168_K	1.041	0.79
7_F	11_E	1.033	0.79
117_A	120_E	1.018	0.78
84_R	95_Y	1.001	0.76
60_F	76_A	0.999	0.76
32_E	39_E	0.993	0.76
12_A	15_A	0.991	0.76
142_L	149_L	0.986	0.75
60_F	72_L	0.984	0.75
155_A	158_E	0.975	0.74
8_K	11_E	0.972	0.74
203_I	208_D	0.969	0.74
121_A	124_P	0.966	0.74
109_P	115_L	0.964	0.74
61_Y	171_W	0.962	0.73
117_A	121_A	0.957	0.73
79_P	98_V	0.951	0.73
114_K	117_A	0.950	0.73
12_A	19_A	0.945	0.72
200_G	211_P	0.937	0.72
59_A	190_L	0.922	0.70
29_A	35_C	0.921	0.70
31_T	36_N	0.921	0.70
33_V	36_N	0.917	0.70
9_T	18_Q	0.913	0.70
95_Y	99_D	0.909	0.69
174_D	178_D	0.908	0.69
38_E	44_A	0.907	0.69
194_C	215_L	0.902	0.69
16_A	21_S	0.901	0.68
65_I	73_D	0.896	0.68
194_C	197_Y	0.893	0.68
145_L	192_L	0.890	0.68
22_A	28_T	0.882	0.67
99_D	102_Q	0.872	0.66
19_A	27_A	0.871	0.66
151_G	199_R	0.865	0.65
37_G	41_T	0.864	0.65
87_G	91_D	0.857	0.65
153_E	202_P	0.850	0.64
34_E	126_A	0.844	0.63
142_L	150_R	0.839	0.63
181_P	192_L	0.839	0.63
8_K	67_R	0.826	0.62
7_F	15_A	0.823	0.61
100_A	145_L	0.819	0.61
72_L	105_L	0.816	0.61
113_E	117_A	0.814	0.61
112_V	115_L	0.814	0.61
26_A	30_P	0.813	0.60
53_A	59_A	0.812	0.60
57_L	65_I	0.811	0.60
118_A	137_L	0.808	0.60
192_L	196_A	0.808	0.60
144_L	148_L	0.807	0.60
29_A	32_E	0.802	0.59
6_K	9_T	0.792	0.58
17_L	21_S	0.791	0.58
70_E	74_R	0.786	0.58
208_D	215_L	0.785	0.58
51_A	82_L	0.783	0.58
96_A	100_A	0.779	0.57
86_S	89_E	0.778	0.57
69_R	72_L	0.776	0.57
25_A	29_A	0.774	0.57
142_L	146_R	0.773	0.57
15_A	19_A	0.773	0.57
141_P	192_L	0.768	0.56
171_W	186_A	0.768	0.56
62_L	185_L	0.767	0.56
19_A	24_F	0.766	0.56
36_N	42_L	0.764	0.56
6_K	10_W	0.764	0.56
107_G	111_L	0.761	0.55
60_F	64_L	0.760	0.55
39_E	42_L	0.754	0.55
81_E	85_E	0.753	0.55
140_P	180_D	0.752	0.55
144_L	156_F	0.751	0.54
33_V	37_G	0.751	0.54
113_E	116_V	0.747	0.54
14_V	18_Q	0.742	0.54
162_E	166_L	0.741	0.53
16_A	19_A	0.736	0.53
23_L	28_T	0.734	0.53
31_T	37_G	0.731	0.52
33_V	46_G	0.726	0.52
155_A	159_A	0.725	0.52
6_K	23_L	0.723	0.52
31_T	39_E	0.723	0.52
111_L	114_K	0.720	0.51
69_R	198_D	0.720	0.51
147_A	159_A	0.718	0.51
25_A	28_T	0.716	0.51
9_T	14_V	0.711	0.50
111_L	124_P	0.699	0.49
145_L	193_A	0.698	0.49
47_P	128_I	0.697	0.49
112_V	123_D	0.697	0.49
63_A	156_F	0.695	0.49
103_A	108_R	0.695	0.49
63_A	134_L	0.691	0.48
185_L	214_L	0.690	0.48
159_A	192_L	0.689	0.48
23_L	26_A	0.687	0.48
151_G	201_F	0.686	0.48
20_G	24_F	0.683	0.48
146_R	155_A	0.682	0.48
91_D	196_A	0.679	0.47
33_V	64_L	0.679	0.47
64_L	127_R	0.679	0.47
119_L	150_R	0.676	0.47
119_L	181_P	0.674	0.47
68_D	91_D	0.673	0.47
164_L	193_A	0.670	0.46
20_G	27_A	0.667	0.46
34_E	40_R	0.664	0.46
34_E	37_G	0.660	0.45
32_E	44_A	0.659	0.45
156_F	191_A	0.659	0.45
20_G	59_A	0.656	0.45
12_A	21_S	0.653	0.45
103_A	166_L	0.653	0.45
18_Q	21_S	0.650	0.44
29_A	33_V	0.649	0.44
38_E	41_T	0.647	0.44
97_W	101_L	0.647	0.44
149_L	215_L	0.647	0.44
23_L	30_P	0.644	0.44
167_H	183_G	0.643	0.44
21_S	26_A	0.642	0.44
70_E	73_D	0.641	0.43
12_A	22_A	0.638	0.43
67_R	197_Y	0.636	0.43
67_R	170_Y	0.634	0.43
21_S	27_A	0.632	0.43
144_L	186_A	0.627	0.42
9_T	16_A	0.626	0.42
63_A	75_L	0.622	0.42
100_A	192_L	0.621	0.42
119_L	123_D	0.615	0.41
7_F	19_A	0.615	0.41
48_E	68_D	0.612	0.41
96_A	177_R	0.612	0.41
176_R	196_A	0.612	0.41
103_A	110_G	0.610	0.40
212_K	215_L	0.606	0.40
62_L	187_L	0.603	0.40
168_K	204_E	0.602	0.40
93_Y	101_L	0.601	0.40
56_W	189_P	0.599	0.39
30_P	45_T	0.597	0.39
60_F	105_L	0.597	0.39
12_A	20_G	0.597	0.39
95_Y	98_V	0.596	0.39
34_E	38_E	0.592	0.39
23_L	27_A	0.592	0.39
121_A	135_L	0.592	0.39
63_A	191_A	0.590	0.39
163_A	183_G	0.589	0.38
30_P	34_E	0.587	0.38
110_G	131_R	0.585	0.38
160_L	167_H	0.585	0.38
41_T	69_R	0.584	0.38
153_E	199_R	0.582	0.38
53_A	93_Y	0.582	0.38
145_L	167_H	0.581	0.38
11_E	15_A	0.580	0.38
21_S	25_A	0.577	0.37
76_A	201_F	0.576	0.37
60_F	195_L	0.574	0.37
31_T	127_R	0.565	0.36
157_N	161_A	0.559	0.36
80_L	103_A	0.558	0.36
14_V	21_S	0.550	0.35
94_D	97_W	0.550	0.35
154_E	191_A	0.548	0.35
84_R	92_E	0.547	0.35
17_L	71_R	0.544	0.34
168_K	209_Y	0.544	0.34
22_A	27_A	0.543	0.34
183_G	186_A	0.543	0.34
67_R	79_P	0.542	0.34
17_L	20_G	0.541	0.34
14_V	20_G	0.541	0.34
116_V	120_E	0.538	0.34
103_A	106_L	0.537	0.34
88_A	91_D	0.536	0.34
121_A	150_R	0.536	0.34
30_P	125_D	0.535	0.34
34_E	50_Y	0.532	0.33
31_T	43_P	0.532	0.33
138_L	145_L	0.532	0.33
206_E	213_E	0.531	0.33
99_D	108_R	0.530	0.33
137_L	183_G	0.530	0.33
18_Q	23_L	0.530	0.33
66_S	141_P	0.529	0.33
190_L	206_E	0.528	0.33
31_T	44_A	0.523	0.32
195_L	215_L	0.522	0.32
12_A	29_A	0.520	0.32
147_A	150_R	0.518	0.32
56_W	101_L	0.517	0.32
53_A	83_L	0.514	0.32
109_P	116_V	0.511	0.31
167_H	188_G	0.508	0.31
182_E	185_L	0.507	0.31
22_A	25_A	0.507	0.31
32_E	40_R	0.506	0.31
58_D	175_E	0.502	0.31
7_F	10_W	0.502	0.31
72_L	76_A	0.502	0.31
50_Y	182_E	0.501	0.31
43_P	49_S	0.501	0.31
9_T	68_D	0.500	0.30

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2fefA	3	0.8047	38.7	0.914	Contact Map
4lixA	1	0.6651	4.4	0.945	Contact Map
3e9vA	1	0.3953	3.4	0.947	Contact Map
3s9vA	1	0.6791	3.4	0.947	Contact Map
2debA	1	0.907	2.9	0.949	Contact Map
3iarA	1	0.9349	2.9	0.95	Contact Map
2z15A	1	0.4233	2.3	0.952	Contact Map
3nr1A	2	0.2884	2.2	0.952	Contact Map
1xl7A	1	0.9116	2.1	0.953	Contact Map
1n0qA	2	0.4326	2	0.953	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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