GREMLIN Database
Imm49 - Immunity protein 49
PFAM: PF15575 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 215 (209)
Sequences: 845 (685)
Seq/√Len: 47.4
META: 0.373

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
152_D155_A5.4401.00
67_R198_D5.3391.00
186_A189_P4.3061.00
31_T34_E3.2211.00
157_N204_E2.8641.00
31_T35_C2.7051.00
167_H186_A2.6441.00
32_E35_C2.5801.00
67_R194_C2.5341.00
100_A118_A2.4811.00
163_A189_P2.4431.00
157_N203_I2.4071.00
18_Q24_F2.3421.00
167_H171_W2.3231.00
160_L193_A2.2501.00
153_E157_N2.2291.00
161_A165_E2.0691.00
36_N39_E2.0441.00
37_G44_A1.9810.99
156_F160_L1.8960.99
193_A203_I1.8340.99
194_C198_D1.8270.99
18_Q22_A1.8030.99
162_E165_E1.7800.99
161_A205_V1.7120.98
56_W59_A1.6880.98
11_E14_V1.6790.98
56_W60_F1.6760.98
144_L189_P1.6740.98
68_D71_R1.6610.98
171_W183_G1.6520.98
16_A24_F1.6440.98
66_S194_C1.6230.97
174_D177_R1.5900.97
39_E44_A1.5480.97
36_N40_R1.5420.97
54_G58_D1.5410.97
11_E16_A1.5390.97
193_A215_L1.5340.96
96_A121_A1.5260.96
14_V17_L1.5030.96
96_A114_K1.5030.96
37_G40_R1.4970.96
211_P214_L1.4960.96
99_D103_A1.4870.96
100_A103_A1.4480.95
160_L210_L1.4470.95
10_W13_L1.4240.95
82_L86_S1.4070.94
48_E51_A1.4060.94
80_L102_Q1.3990.94
60_F160_L1.3960.94
101_L106_L1.3870.94
12_A17_L1.3860.94
39_E43_P1.3750.94
163_A167_H1.3690.93
143_E162_E1.3630.93
98_V102_Q1.3580.93
93_Y100_A1.3500.93
103_A114_K1.3430.93
153_E201_F1.3280.92
110_G113_E1.3200.92
164_L207_S1.3040.92
16_A22_A1.3030.92
16_A20_G1.2800.91
104_Y148_L1.2770.91
163_A171_W1.2710.90
41_T44_A1.2550.90
133_L137_L1.2480.90
7_F13_L1.2470.90
173_A177_R1.2420.89
197_Y215_L1.2400.89
165_E168_K1.2200.89
163_A170_Y1.2030.88
163_A186_A1.2020.88
160_L205_V1.1930.87
65_I194_C1.1860.87
183_G209_Y1.1810.87
34_E41_T1.1810.87
64_L191_A1.1790.87
32_E37_G1.1390.85
29_A34_E1.1330.85
9_T12_A1.1310.84
195_L199_R1.1280.84
34_E39_E1.1170.84
19_A214_L1.1070.83
206_E212_K1.1030.83
56_W186_A1.0960.83
164_L196_A1.0880.82
26_A29_A1.0830.82
16_A23_L1.0790.82
135_L155_A1.0780.82
164_L205_V1.0780.82
11_E18_Q1.0700.81
12_A16_A1.0620.81
34_E43_P1.0610.80
9_T13_L1.0510.80
99_D114_K1.0410.79
70_E168_K1.0410.79
7_F11_E1.0330.79
117_A120_E1.0180.78
84_R95_Y1.0010.76
60_F76_A0.9990.76
32_E39_E0.9930.76
12_A15_A0.9910.76
142_L149_L0.9860.75
60_F72_L0.9840.75
155_A158_E0.9750.74
8_K11_E0.9720.74
203_I208_D0.9690.74
121_A124_P0.9660.74
109_P115_L0.9640.74
61_Y171_W0.9620.73
117_A121_A0.9570.73
79_P98_V0.9510.73
114_K117_A0.9500.73
12_A19_A0.9450.72
200_G211_P0.9370.72
59_A190_L0.9220.70
29_A35_C0.9210.70
31_T36_N0.9210.70
33_V36_N0.9170.70
9_T18_Q0.9130.70
95_Y99_D0.9090.69
174_D178_D0.9080.69
38_E44_A0.9070.69
194_C215_L0.9020.69
16_A21_S0.9010.68
65_I73_D0.8960.68
194_C197_Y0.8930.68
145_L192_L0.8900.68
22_A28_T0.8820.67
99_D102_Q0.8720.66
19_A27_A0.8710.66
151_G199_R0.8650.65
37_G41_T0.8640.65
87_G91_D0.8570.65
153_E202_P0.8500.64
34_E126_A0.8440.63
142_L150_R0.8390.63
181_P192_L0.8390.63
8_K67_R0.8260.62
7_F15_A0.8230.61
100_A145_L0.8190.61
72_L105_L0.8160.61
113_E117_A0.8140.61
112_V115_L0.8140.61
26_A30_P0.8130.60
53_A59_A0.8120.60
57_L65_I0.8110.60
118_A137_L0.8080.60
192_L196_A0.8080.60
144_L148_L0.8070.60
29_A32_E0.8020.59
6_K9_T0.7920.58
17_L21_S0.7910.58
70_E74_R0.7860.58
208_D215_L0.7850.58
51_A82_L0.7830.58
96_A100_A0.7790.57
86_S89_E0.7780.57
69_R72_L0.7760.57
25_A29_A0.7740.57
142_L146_R0.7730.57
15_A19_A0.7730.57
141_P192_L0.7680.56
171_W186_A0.7680.56
62_L185_L0.7670.56
19_A24_F0.7660.56
36_N42_L0.7640.56
6_K10_W0.7640.56
107_G111_L0.7610.55
60_F64_L0.7600.55
39_E42_L0.7540.55
81_E85_E0.7530.55
140_P180_D0.7520.55
144_L156_F0.7510.54
33_V37_G0.7510.54
113_E116_V0.7470.54
14_V18_Q0.7420.54
162_E166_L0.7410.53
16_A19_A0.7360.53
23_L28_T0.7340.53
31_T37_G0.7310.52
33_V46_G0.7260.52
155_A159_A0.7250.52
6_K23_L0.7230.52
31_T39_E0.7230.52
111_L114_K0.7200.51
69_R198_D0.7200.51
147_A159_A0.7180.51
25_A28_T0.7160.51
9_T14_V0.7110.50
111_L124_P0.6990.49
145_L193_A0.6980.49
47_P128_I0.6970.49
112_V123_D0.6970.49
63_A156_F0.6950.49
103_A108_R0.6950.49
63_A134_L0.6910.48
185_L214_L0.6900.48
159_A192_L0.6890.48
23_L26_A0.6870.48
151_G201_F0.6860.48
20_G24_F0.6830.48
146_R155_A0.6820.48
91_D196_A0.6790.47
33_V64_L0.6790.47
64_L127_R0.6790.47
119_L150_R0.6760.47
119_L181_P0.6740.47
68_D91_D0.6730.47
164_L193_A0.6700.46
20_G27_A0.6670.46
34_E40_R0.6640.46
34_E37_G0.6600.45
32_E44_A0.6590.45
156_F191_A0.6590.45
20_G59_A0.6560.45
12_A21_S0.6530.45
103_A166_L0.6530.45
18_Q21_S0.6500.44
29_A33_V0.6490.44
38_E41_T0.6470.44
97_W101_L0.6470.44
149_L215_L0.6470.44
23_L30_P0.6440.44
167_H183_G0.6430.44
21_S26_A0.6420.44
70_E73_D0.6410.43
12_A22_A0.6380.43
67_R197_Y0.6360.43
67_R170_Y0.6340.43
21_S27_A0.6320.43
144_L186_A0.6270.42
9_T16_A0.6260.42
63_A75_L0.6220.42
100_A192_L0.6210.42
119_L123_D0.6150.41
7_F19_A0.6150.41
48_E68_D0.6120.41
96_A177_R0.6120.41
176_R196_A0.6120.41
103_A110_G0.6100.40
212_K215_L0.6060.40
62_L187_L0.6030.40
168_K204_E0.6020.40
93_Y101_L0.6010.40
56_W189_P0.5990.39
30_P45_T0.5970.39
60_F105_L0.5970.39
12_A20_G0.5970.39
95_Y98_V0.5960.39
34_E38_E0.5920.39
23_L27_A0.5920.39
121_A135_L0.5920.39
63_A191_A0.5900.39
163_A183_G0.5890.38
30_P34_E0.5870.38
110_G131_R0.5850.38
160_L167_H0.5850.38
41_T69_R0.5840.38
153_E199_R0.5820.38
53_A93_Y0.5820.38
145_L167_H0.5810.38
11_E15_A0.5800.38
21_S25_A0.5770.37
76_A201_F0.5760.37
60_F195_L0.5740.37
31_T127_R0.5650.36
157_N161_A0.5590.36
80_L103_A0.5580.36
14_V21_S0.5500.35
94_D97_W0.5500.35
154_E191_A0.5480.35
84_R92_E0.5470.35
17_L71_R0.5440.34
168_K209_Y0.5440.34
22_A27_A0.5430.34
183_G186_A0.5430.34
67_R79_P0.5420.34
17_L20_G0.5410.34
14_V20_G0.5410.34
116_V120_E0.5380.34
103_A106_L0.5370.34
88_A91_D0.5360.34
121_A150_R0.5360.34
30_P125_D0.5350.34
34_E50_Y0.5320.33
31_T43_P0.5320.33
138_L145_L0.5320.33
206_E213_E0.5310.33
99_D108_R0.5300.33
137_L183_G0.5300.33
18_Q23_L0.5300.33
66_S141_P0.5290.33
190_L206_E0.5280.33
31_T44_A0.5230.32
195_L215_L0.5220.32
12_A29_A0.5200.32
147_A150_R0.5180.32
56_W101_L0.5170.32
53_A83_L0.5140.32
109_P116_V0.5110.31
167_H188_G0.5080.31
182_E185_L0.5070.31
22_A25_A0.5070.31
32_E40_R0.5060.31
58_D175_E0.5020.31
7_F10_W0.5020.31
72_L76_A0.5020.31
50_Y182_E0.5010.31
43_P49_S0.5010.31
9_T68_D0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fefA 3 0.8047 38.7 0.914 Contact Map
4lixA 1 0.6651 4.4 0.945 Contact Map
3e9vA 1 0.3953 3.4 0.947 Contact Map
3s9vA 1 0.6791 3.4 0.947 Contact Map
2debA 1 0.907 2.9 0.949 Contact Map
3iarA 1 0.9349 2.9 0.95 Contact Map
2z15A 1 0.4233 2.3 0.952 Contact Map
3nr1A 2 0.2884 2.2 0.952 Contact Map
1xl7A 1 0.9116 2.1 0.953 Contact Map
1n0qA 2 0.4326 2 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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