GREMLIN Database
Imm40 - Immunity protein 40
PFAM: PF15569 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 90 (88)
Sequences: 501 (432)
Seq/√Len: 46.1
META: 0.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_W20_A5.3921.00
37_Y46_P4.5631.00
49_D76_Y3.3861.00
30_A61_Y2.8241.00
53_C64_R2.7281.00
13_K16_D2.6461.00
21_L66_I2.3791.00
61_Y64_R2.2831.00
21_L31_I2.2341.00
44_I85_L1.8790.99
25_R70_R1.8570.99
9_E87_S1.8310.99
36_V73_I1.8020.99
53_C61_Y1.7900.99
49_D72_Y1.6540.98
14_R76_Y1.5420.96
30_A64_R1.4590.95
53_C68_K1.4250.94
21_L69_A1.3850.93
7_I37_Y1.3690.93
14_R36_V1.3670.93
25_R63_E1.3140.91
40_S45_E1.3040.91
25_R66_I1.2850.90
10_Y23_L1.2830.90
22_D70_R1.2770.90
53_C69_A1.2770.90
48_Y69_A1.2530.89
36_V76_Y1.1750.86
35_D52_Y1.1690.86
32_L72_Y1.1670.85
14_R18_L1.1460.84
79_R82_D1.1130.83
57_S60_D1.0680.80
36_V86_F1.0440.78
10_Y88_L1.0350.78
10_Y20_A1.0320.78
37_Y87_S1.0110.76
12_W24_L1.0060.76
12_W29_I1.0040.76
35_D50_N0.9970.75
53_C56_K0.9780.74
17_A73_I0.9680.73
55_R58_D0.9460.71
55_R61_Y0.9360.70
70_R74_E0.9200.69
21_L73_I0.9090.68
49_D73_I0.9050.68
80_N83_D0.9030.68
10_Y16_D0.8890.66
80_N84_F0.8730.65
86_F89_V0.8720.65
9_E23_L0.8670.64
38_R47_T0.8660.64
57_S71_E0.8650.64
52_Y55_R0.8630.64
72_Y76_Y0.8410.62
14_R77_P0.8350.61
57_S73_I0.8340.61
12_W27_K0.8240.60
39_L45_E0.8230.60
30_A53_C0.8160.60
14_R17_A0.8080.59
18_L70_R0.7970.58
53_C62_V0.7890.57
18_L73_I0.7710.55
11_A36_V0.7640.55
12_W23_L0.7630.54
24_L29_I0.7550.54
56_K63_E0.7550.54
67_E71_E0.7370.52
57_S76_Y0.7180.50
27_K37_Y0.7140.50
31_I81_G0.7090.49
12_W66_I0.6940.48
14_R49_D0.6900.47
15_E31_I0.6830.47
9_E46_P0.6790.46
9_E12_W0.6710.45
58_D62_V0.6650.45
46_P50_N0.6650.45
2_L6_G0.6640.45
24_L30_A0.6600.44
60_D74_E0.6540.44
23_L26_E0.6510.44
44_I77_P0.6500.43
58_D61_Y0.6460.43
45_E76_Y0.6400.42
8_N12_W0.6220.41
62_V66_I0.6210.41
25_R43_K0.6170.40
42_G56_K0.6110.40
38_R84_F0.6080.39
17_A21_L0.6080.39
41_N84_F0.6070.39
21_L27_K0.6040.39
25_R28_G0.5980.38
77_P81_G0.5840.37
60_D65_S0.5820.37
59_E75_N0.5810.37
39_L83_D0.5770.37
58_D73_I0.5690.36
31_I45_E0.5670.36
8_N53_C0.5570.35
29_I61_Y0.5530.34
32_L35_D0.5520.34
2_L24_L0.5520.34
6_G39_L0.5500.34
19_E59_E0.5480.34
7_I87_S0.5480.34
63_E70_R0.5450.34
56_K75_N0.5400.33
74_E79_R0.5380.33
30_A38_R0.5360.33
56_K83_D0.5360.33
14_R73_I0.5320.33
26_E71_E0.5300.32
78_K82_D0.5300.32
59_E63_E0.5290.32
68_K75_N0.5270.32
22_D75_N0.5240.32
21_L88_L0.5230.32
6_G17_A0.5220.32
46_P49_D0.5180.31
41_N83_D0.5170.31
49_D84_F0.5170.31
24_L39_L0.5120.31
13_K61_Y0.5100.31
22_D59_E0.5090.31
23_L47_T0.5050.30
52_Y72_Y0.5020.30
71_E75_N0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fhzA 1 0.9778 23.2 0.893 Contact Map
2ky4A 1 0.9111 16.2 0.9 Contact Map
1yq2A 4 0.8889 10.4 0.909 Contact Map
4xpqA 2 0.8444 10.3 0.909 Contact Map
3odmA 6 0.8889 9.5 0.91 Contact Map
1lddA 4 0.4444 8.3 0.912 Contact Map
2m83A 1 0.7889 8.1 0.913 Contact Map
3qe2A 1 0.4 7.7 0.914 Contact Map
4yiiA 1 0.4444 7.4 0.914 Contact Map
3k40A 2 0.8333 6.9 0.915 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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