Imm35 - PFAM28P - GREMLIN Contacts

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Imm35 - Immunity protein 35

PFAM:	PF15567	Sequences: EEAREIAEEYLARLEGPDDELVIVDEATIERPFGWVFFYNSKEYLETGDFRDALANAPIIVDRDDGSLHFVTGTARPILEHYLAD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	85 (75)
Sequences:	1207 (1079)
Seq/√Len:	124.6
META:	0.801

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
42_K	46_E	3.687	1.00
43_E	52_D	2.563	1.00
40_N	44_Y	2.528	1.00
4_R	25_D	2.441	1.00
28_T	38_F	2.231	1.00
10_Y	13_R	1.929	1.00
47_T	52_D	1.922	1.00
8_E	12_A	1.799	1.00
5_E	9_E	1.771	1.00
20_E	42_K	1.751	1.00
34_G	63_R	1.685	1.00
62_D	65_D	1.613	1.00
7_A	59_I	1.607	1.00
30_E	63_R	1.600	1.00
62_D	69_H	1.580	1.00
49_D	52_D	1.576	1.00
50_F	53_A	1.555	1.00
40_N	54_L	1.552	1.00
25_D	28_T	1.520	1.00
7_A	61_V	1.488	1.00
29_I	38_F	1.482	1.00
22_V	42_K	1.467	1.00
74_T	77_P	1.447	1.00
39_Y	56_N	1.395	1.00
40_N	53_A	1.348	1.00
73_G	76_R	1.322	1.00
40_N	45_L	1.301	1.00
2_E	5_E	1.281	1.00
57_A	72_T	1.277	1.00
60_I	72_T	1.260	1.00
33_F	60_I	1.220	0.99
7_A	23_I	1.206	0.99
7_A	11_L	1.196	0.99
57_A	74_T	1.162	0.99
24_V	27_A	1.140	0.99
39_Y	58_P	1.111	0.99
43_E	46_E	1.107	0.99
72_T	77_P	1.100	0.99
4_R	8_E	1.059	0.98
71_V	77_P	1.030	0.98
62_D	67_S	0.975	0.97
4_R	37_F	0.972	0.97
22_V	25_D	0.956	0.97
10_Y	59_I	0.955	0.97
33_F	62_D	0.954	0.97
23_I	37_F	0.928	0.96
24_V	45_L	0.921	0.96
50_F	55_A	0.900	0.96
23_I	28_T	0.899	0.96
65_D	69_H	0.899	0.96
39_Y	57_A	0.861	0.94
12_A	15_E	0.847	0.94
15_E	18_D	0.832	0.93
44_Y	53_A	0.823	0.93
5_E	8_E	0.815	0.93
33_F	36_V	0.802	0.92
34_G	37_F	0.796	0.92
37_F	59_I	0.793	0.92
41_S	53_A	0.786	0.91
44_Y	48_G	0.756	0.90
19_D	42_K	0.754	0.89
65_D	68_L	0.736	0.88
6_I	66_G	0.722	0.87
13_R	17_P	0.721	0.87
36_V	58_P	0.695	0.85
45_L	54_L	0.688	0.85
10_Y	14_L	0.684	0.84
22_V	28_T	0.684	0.84
22_V	26_E	0.671	0.83
23_I	26_E	0.670	0.83
9_E	68_L	0.668	0.83
72_T	75_A	0.666	0.83
5_E	12_A	0.657	0.82
28_T	37_F	0.650	0.81
13_R	68_L	0.641	0.80
6_I	13_R	0.629	0.79
71_V	74_T	0.625	0.79
3_A	35_W	0.623	0.78
24_V	40_N	0.622	0.78
56_N	60_I	0.617	0.78
16_G	50_F	0.617	0.78
43_E	49_D	0.616	0.78
8_E	25_D	0.616	0.78
41_S	54_L	0.616	0.78
7_A	10_Y	0.609	0.77
39_Y	45_L	0.604	0.76
36_V	39_Y	0.602	0.76
68_L	71_V	0.578	0.73
8_E	68_L	0.577	0.73
59_I	64_D	0.573	0.72
17_P	43_E	0.573	0.72
43_E	47_T	0.569	0.72
29_I	33_F	0.568	0.72
34_G	59_I	0.565	0.71
12_A	17_P	0.555	0.70
9_E	13_R	0.554	0.70
34_G	72_T	0.550	0.69
10_Y	71_V	0.547	0.69
45_L	48_G	0.545	0.69
13_R	63_R	0.544	0.69
35_W	60_I	0.541	0.68
4_R	11_L	0.533	0.67
14_L	17_P	0.532	0.67
46_E	49_D	0.529	0.66
52_D	55_A	0.521	0.65
51_R	55_A	0.520	0.65
14_L	64_D	0.516	0.65
31_R	36_V	0.516	0.65
42_K	48_G	0.507	0.63
13_R	64_D	0.506	0.63
24_V	42_K	0.504	0.63
41_S	61_V	0.500	0.62

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3fg6A	4	0.5176	12.8	0.889	Contact Map
4em8A	2	0.3412	12.4	0.889	Contact Map
3s5pA	4	0.3059	11.4	0.891	Contact Map
4lflA	2	0.3647	10.9	0.892	Contact Map
1o1xA	3	0.3529	9.4	0.896	Contact Map
3nqzA	1	0.8118	8.3	0.898	Contact Map
1tisA	2	0.7176	7	0.901	Contact Map
3sgwA	4	0.4588	6.5	0.903	Contact Map
3ph3A	2	0.4118	5.2	0.907	Contact Map
2vvpA	2	0.5059	5.2	0.907	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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