GREMLIN Database
Imm35 - Immunity protein 35
PFAM: PF15567 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 85 (75)
Sequences: 1207 (1079)
Seq/√Len: 124.6
META: 0.801

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_K46_E3.6871.00
43_E52_D2.5631.00
40_N44_Y2.5281.00
4_R25_D2.4411.00
28_T38_F2.2311.00
10_Y13_R1.9291.00
47_T52_D1.9221.00
8_E12_A1.7991.00
5_E9_E1.7711.00
20_E42_K1.7511.00
34_G63_R1.6851.00
62_D65_D1.6131.00
7_A59_I1.6071.00
30_E63_R1.6001.00
62_D69_H1.5801.00
49_D52_D1.5761.00
50_F53_A1.5551.00
40_N54_L1.5521.00
25_D28_T1.5201.00
7_A61_V1.4881.00
29_I38_F1.4821.00
22_V42_K1.4671.00
74_T77_P1.4471.00
39_Y56_N1.3951.00
40_N53_A1.3481.00
73_G76_R1.3221.00
40_N45_L1.3011.00
2_E5_E1.2811.00
57_A72_T1.2771.00
60_I72_T1.2601.00
33_F60_I1.2200.99
7_A23_I1.2060.99
7_A11_L1.1960.99
57_A74_T1.1620.99
24_V27_A1.1400.99
39_Y58_P1.1110.99
43_E46_E1.1070.99
72_T77_P1.1000.99
4_R8_E1.0590.98
71_V77_P1.0300.98
62_D67_S0.9750.97
4_R37_F0.9720.97
22_V25_D0.9560.97
10_Y59_I0.9550.97
33_F62_D0.9540.97
23_I37_F0.9280.96
24_V45_L0.9210.96
50_F55_A0.9000.96
23_I28_T0.8990.96
65_D69_H0.8990.96
39_Y57_A0.8610.94
12_A15_E0.8470.94
15_E18_D0.8320.93
44_Y53_A0.8230.93
5_E8_E0.8150.93
33_F36_V0.8020.92
34_G37_F0.7960.92
37_F59_I0.7930.92
41_S53_A0.7860.91
44_Y48_G0.7560.90
19_D42_K0.7540.89
65_D68_L0.7360.88
6_I66_G0.7220.87
13_R17_P0.7210.87
36_V58_P0.6950.85
45_L54_L0.6880.85
10_Y14_L0.6840.84
22_V28_T0.6840.84
22_V26_E0.6710.83
23_I26_E0.6700.83
9_E68_L0.6680.83
72_T75_A0.6660.83
5_E12_A0.6570.82
28_T37_F0.6500.81
13_R68_L0.6410.80
6_I13_R0.6290.79
71_V74_T0.6250.79
3_A35_W0.6230.78
24_V40_N0.6220.78
56_N60_I0.6170.78
16_G50_F0.6170.78
43_E49_D0.6160.78
8_E25_D0.6160.78
41_S54_L0.6160.78
7_A10_Y0.6090.77
39_Y45_L0.6040.76
36_V39_Y0.6020.76
68_L71_V0.5780.73
8_E68_L0.5770.73
59_I64_D0.5730.72
17_P43_E0.5730.72
43_E47_T0.5690.72
29_I33_F0.5680.72
34_G59_I0.5650.71
12_A17_P0.5550.70
9_E13_R0.5540.70
34_G72_T0.5500.69
10_Y71_V0.5470.69
45_L48_G0.5450.69
13_R63_R0.5440.69
35_W60_I0.5410.68
4_R11_L0.5330.67
14_L17_P0.5320.67
46_E49_D0.5290.66
52_D55_A0.5210.65
51_R55_A0.5200.65
14_L64_D0.5160.65
31_R36_V0.5160.65
42_K48_G0.5070.63
13_R64_D0.5060.63
24_V42_K0.5040.63
41_S61_V0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fg6A 4 0.5176 12.8 0.889 Contact Map
4em8A 2 0.3412 12.4 0.889 Contact Map
3s5pA 4 0.3059 11.4 0.891 Contact Map
4lflA 2 0.3647 10.9 0.892 Contact Map
1o1xA 3 0.3529 9.4 0.896 Contact Map
3nqzA 1 0.8118 8.3 0.898 Contact Map
1tisA 2 0.7176 7 0.901 Contact Map
3sgwA 4 0.4588 6.5 0.903 Contact Map
3ph3A 2 0.4118 5.2 0.907 Contact Map
2vvpA 2 0.5059 5.2 0.907 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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