GREMLIN Database
Imm17 - Immunity protein 17
PFAM: PF15562 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 61 (57)
Sequences: 1154 (976)
Seq/√Len: 129.2
META: 0.919

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_N39_R3.1231.00
12_L16_F2.6901.00
13_G18_W2.6811.00
19_D39_R2.5871.00
13_G22_F2.3751.00
14_A47_G2.2131.00
7_G50_G1.9691.00
37_F41_G1.9481.00
12_L18_W1.8301.00
11_L47_G1.7301.00
55_V59_L1.7291.00
14_A50_G1.6931.00
48_L52_L1.6831.00
4_I54_I1.5281.00
11_L15_I1.5051.00
32_F36_L1.4851.00
34_V42_A1.4741.00
19_D23_N1.3461.00
13_G21_F1.2231.00
4_I57_G1.1520.99
7_G57_G1.1480.99
17_N47_G1.1420.99
21_F46_Y1.0970.99
41_G45_F1.0870.99
40_K44_I1.0740.99
17_N43_R1.0430.98
7_G14_A1.0370.98
1_L5_A1.0150.98
10_S21_F1.0110.98
32_F35_K1.0030.98
11_L50_G0.9820.98
53_L56_L0.9770.98
10_S24_S0.9750.98
14_A22_F0.9430.97
5_A9_F0.9180.96
11_L54_I0.9180.96
13_G16_F0.8690.95
22_F42_A0.8550.95
44_I47_G0.8370.94
8_L48_L0.8230.94
42_A46_Y0.7930.92
40_K43_R0.7840.92
46_Y50_G0.7810.92
7_G21_F0.7790.92
39_R43_R0.7620.91
11_L14_A0.7340.89
19_D40_K0.7240.88
9_F20_W0.7120.88
2_F31_R0.6860.86
51_L54_I0.6700.84
17_N20_W0.6670.84
56_L59_L0.6610.83
33_F38_G0.6600.83
12_L38_G0.6580.83
11_L51_L0.6530.83
38_G52_L0.6520.83
22_F39_R0.6500.82
2_F7_G0.6460.82
14_A17_N0.6450.82
15_I47_G0.6350.81
27_A45_F0.6300.80
51_L59_L0.5980.77
12_L15_I0.5920.76
5_A55_V0.5910.76
2_F54_I0.5890.76
27_A46_Y0.5840.75
26_K41_G0.5760.74
17_N22_F0.5700.74
17_N34_V0.5690.73
31_R34_V0.5680.73
9_F16_F0.5610.72
34_V37_F0.5580.72
3_F53_L0.5560.72
31_R35_K0.5530.71
33_F37_F0.5480.71
33_F40_K0.5410.70
10_S50_G0.5360.69
46_Y49_L0.5260.68
12_L20_W0.5220.67
34_V56_L0.5190.66
47_G52_L0.5160.66
26_K46_Y0.5090.65
18_W22_F0.5090.65
5_A25_R0.5050.64
3_F57_G0.5040.64
45_F48_L0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zxeB 1 0.377 16.8 0.798 Contact Map
3wguB 1 0.7049 5.4 0.838 Contact Map
4tq3A 1 0.9672 3.2 0.855 Contact Map
3pe5A 1 0 3.1 0.856 Contact Map
4httA 1 0.4426 2.9 0.858 Contact Map
4nv5A 1 0.4262 2.8 0.859 Contact Map
4b4aA 1 0.4426 2.7 0.86 Contact Map
4od4A 1 0.9672 2.6 0.861 Contact Map
2ww8A 1 0 2.5 0.864 Contact Map
3ixzB 1 0.3607 2.1 0.868 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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