GREMLIN Database
Ntox50 - Bacterial toxin 50
PFAM: PF15542 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 105 (95)
Sequences: 884 (777)
Seq/√Len: 79.7
META: 0.83

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_Q45_D3.7821.00
6_G12_T3.5651.00
66_R91_T3.2461.00
93_H102_V3.0381.00
44_V99_A2.5351.00
69_F90_G2.3501.00
6_G14_N2.3371.00
3_G7_K2.1751.00
33_L40_A1.9661.00
3_G13_N1.9521.00
65_E94_Y1.8461.00
49_G65_E1.8321.00
75_V86_P1.8231.00
4_K95_S1.7251.00
75_V84_Y1.6501.00
36_S39_D1.6161.00
78_D81_T1.6131.00
3_G14_N1.6071.00
56_T60_K1.5651.00
91_T104_A1.5490.99
68_D89_R1.5200.99
72_I88_T1.4720.99
2_P6_G1.4560.99
42_E46_K1.4500.99
54_I66_R1.4270.99
76_Y85_T1.4180.99
73_I90_G1.3980.99
10_P32_Y1.2580.98
68_D88_T1.1710.96
35_I40_A1.1560.96
54_I91_T1.1490.96
51_G65_E1.1420.96
66_R104_A1.1310.96
49_G94_Y1.1250.95
64_K91_T1.1220.95
50_T65_E1.1100.95
76_Y104_A1.0890.95
66_R89_R1.0730.94
77_V84_Y1.0700.94
39_D71_K1.0630.94
35_I39_D1.0490.93
58_K63_N1.0490.93
15_Y77_V1.0480.93
53_I63_N1.0360.93
44_V101_I1.0300.93
7_K14_N1.0230.93
4_K7_K1.0210.92
52_E66_R1.0110.92
5_Q9_I0.9820.91
100_H103_P0.9740.91
43_L90_G0.9720.91
24_I27_R0.9610.90
15_Y32_Y0.9470.89
89_R104_A0.9330.89
44_V47_Y0.9240.88
27_R30_P0.9150.88
72_I86_P0.9140.88
46_K71_K0.8830.86
57_K60_K0.8770.85
78_D83_K0.8710.85
43_L101_I0.8660.85
47_Y50_T0.8560.84
67_V90_G0.8540.84
48_A99_A0.8500.84
9_I12_T0.8380.83
41_Q99_A0.8370.83
50_T94_Y0.8350.82
7_K97_T0.7970.79
35_I38_E0.7950.79
39_D42_E0.7900.79
69_F73_I0.7890.79
48_A65_E0.7880.79
15_Y84_Y0.7830.78
50_T67_V0.7810.78
54_I62_G0.7780.78
47_Y90_G0.7760.78
33_L36_S0.7690.77
56_T62_G0.7600.76
23_L26_G0.7600.76
29_G32_Y0.7590.76
78_D82_G0.7580.76
69_F88_T0.7450.75
42_E45_D0.7380.74
6_G13_N0.7300.73
30_P33_L0.7280.73
33_L37_T0.7250.73
47_Y70_G0.7220.72
79_P82_G0.7070.71
32_Y75_V0.7040.70
90_G101_I0.7010.70
51_G94_Y0.7000.70
4_K10_P0.6880.69
7_K13_N0.6750.67
77_V102_V0.6730.67
37_T71_K0.6730.67
91_T102_V0.6720.67
37_T40_A0.6720.67
64_K93_H0.6660.66
47_Y92_I0.6620.66
5_Q8_H0.6590.65
34_T39_D0.6590.65
76_Y91_T0.6550.65
43_L73_I0.6490.64
8_H100_H0.6390.63
68_D90_G0.6380.63
76_Y81_T0.6360.63
43_L69_F0.6260.61
72_I75_V0.6240.61
2_P37_T0.6230.61
46_K67_V0.6190.61
4_K97_T0.6160.60
41_Q44_V0.6060.59
34_T86_P0.5950.58
55_G63_N0.5890.57
26_G29_G0.5870.57
32_Y84_Y0.5870.57
39_D43_L0.5810.56
76_Y79_P0.5790.55
77_V81_T0.5750.55
4_K14_N0.5700.54
48_A94_Y0.5660.54
31_S34_T0.5620.53
48_A53_I0.5600.53
58_K61_W0.5500.52
96_K100_H0.5480.51
80_K83_K0.5470.51
77_V80_K0.5450.51
40_A101_I0.5390.50
40_A43_L0.5380.50
45_D99_A0.5380.50
34_T75_V0.5360.50
2_P10_P0.5320.49
29_G33_L0.5320.49
51_G92_I0.5250.49
3_G6_G0.5190.48
42_E75_V0.5170.47
38_E42_E0.5170.47
6_G37_T0.5100.47
52_E55_G0.5050.46
2_P12_T0.5030.46
53_I62_G0.5000.45
34_T40_A0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gnzP 1 0.381 6.3 0.923 Contact Map
3st1A 1 0.3714 5.4 0.925 Contact Map
1fmjA 1 0.6952 4.9 0.927 Contact Map
2w2aA 2 0.6857 4.8 0.927 Contact Map
3j7aU 1 0.7429 4.5 0.928 Contact Map
3zeyG 1 0.7048 4.4 0.928 Contact Map
4ujpO 1 0.7048 4 0.93 Contact Map
1vblA 1 0.5143 3.8 0.931 Contact Map
1pclA 1 0.5048 3.7 0.931 Contact Map
4bpeO 1 0.6857 3.6 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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