GREMLIN Database
Ntox37 - Bacterial toxin 37
PFAM: PF15535 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 64 (58)
Sequences: 537 (467)
Seq/√Len: 61.3
META: 0.937

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_G18_S3.5231.00
51_Q57_Y2.9991.00
44_I59_R2.6801.00
52_D58_W2.5451.00
25_N28_T2.5331.00
52_D56_G2.4171.00
49_D59_R1.9081.00
7_G27_K1.8501.00
30_E50_Y1.7530.99
36_H39_P1.7340.99
44_I49_D1.6940.99
14_G20_K1.5880.99
3_P6_E1.5730.99
45_G62_P1.5500.99
11_R24_Y1.3880.97
22_G57_Y1.3680.97
24_Y31_S1.3320.96
13_K20_K1.3310.96
19_G22_G1.2870.95
22_G51_Q1.2510.95
5_G8_W1.2460.95
5_G23_W1.2370.94
61_Y64_G1.2250.94
6_E15_P1.2200.94
18_S21_G1.1600.92
53_P56_G1.0670.89
39_P44_I1.0180.86
24_Y28_T0.9760.84
34_L48_W0.9610.83
8_W32_L0.9410.81
38_D46_P0.9180.80
24_Y51_Q0.9110.79
52_D55_G0.8580.75
30_E33_H0.8460.74
32_L60_V0.8220.72
16_P19_G0.8200.72
6_E27_K0.8030.70
28_T32_L0.8010.70
3_P52_D0.7900.69
34_L39_P0.7890.69
8_W58_W0.7830.68
51_Q55_G0.7800.68
25_N31_S0.7790.68
36_H44_I0.7750.67
13_K27_K0.7490.65
27_K38_D0.7440.64
52_D60_V0.7250.62
37_P53_P0.7200.62
60_V64_G0.7130.61
33_H55_G0.7040.60
26_P31_S0.6920.58
34_L60_V0.6900.58
37_P45_G0.6730.56
22_G31_S0.6700.56
17_G22_G0.6680.56
51_Q54_D0.6630.55
36_H46_P0.6630.55
13_K19_G0.6610.55
13_K18_S0.6540.54
13_K56_G0.6410.53
12_G16_P0.6310.52
9_E20_K0.6210.51
16_P23_W0.6200.50
58_W61_Y0.6160.50
23_W32_L0.6090.49
4_P23_W0.6040.49
35_N38_D0.6000.48
3_P26_P0.5980.48
22_G33_H0.5930.47
59_R64_G0.5840.46
48_W60_V0.5710.45
3_P45_G0.5600.44
3_P48_W0.5600.44
20_K61_Y0.5580.43
23_W37_P0.5580.43
8_W26_P0.5550.43
35_N56_G0.5510.43
23_W48_W0.5450.42
59_R63_D0.5440.42
22_G49_D0.5190.39
45_G64_G0.5140.39
44_I61_Y0.5140.39
58_W63_D0.5070.38
10_W50_Y0.5060.38
3_P15_P0.5050.38
10_W21_G0.5000.37
30_E53_P0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1e0nA 1 0.4219 5 0.9 Contact Map
3iaiA 3 0.3438 2.2 0.916 Contact Map
1xu0A 1 0.3906 2 0.917 Contact Map
3uajB 2 0 1.8 0.92 Contact Map
2xqyA 1 0 1.8 0.92 Contact Map
4besA 2 0.375 1.8 0.92 Contact Map
2p23A 1 0.2188 1.7 0.921 Contact Map
2vxrA 1 0 1.7 0.922 Contact Map
4xhjA 1 0 1.5 0.923 Contact Map
2dk7A 1 0.7812 1.5 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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