GREMLIN Database
RBM39linker - linker between RRM2 and RRM3 domains in RBM39 protein
PFAM: PF15519 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 89 (81)
Sequences: 524 (378)
Seq/√Len: 42.0
META: 0.315

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_N15_S3.0301.00
30_L33_P2.7551.00
45_A48_P2.6351.00
15_S22_K2.2541.00
64_V67_G2.2201.00
43_T48_P2.1460.99
77_N80_D2.1100.99
43_T47_P2.0440.99
4_D7_G2.0150.99
33_P36_A1.8710.99
42_N45_A1.8680.99
4_D9_L1.8560.98
52_P57_A1.7950.98
21_A25_R1.7510.98
51_P62_L1.7190.97
3_D6_G1.7190.97
33_P40_L1.5580.95
24_A27_G1.4810.94
1_L16_R1.4230.93
42_N49_P1.4030.92
12_N17_A1.3450.90
34_G37_G1.2890.88
34_G38_A1.2690.87
37_G41_Q1.2540.87
31_S34_G1.2450.86
11_L17_A1.1920.84
42_N46_A1.1900.84
2_D8_G1.1760.83
46_A52_P1.1520.82
22_K27_G1.1430.81
75_L78_M1.1260.80
52_P58_A1.1040.79
4_D24_A1.0930.78
34_G51_P1.0810.77
4_D13_A1.0720.77
75_L79_F1.0630.76
18_A21_A1.0520.75
81_P84_E1.0380.74
64_V68_I1.0230.73
38_A49_P1.0200.73
48_P51_P1.0190.73
69_A75_L1.0130.73
46_A51_P0.9840.70
39_A42_N0.9830.70
46_A50_A0.9720.69
3_D10_N0.9700.69
35_A40_L0.9690.69
68_I82_A0.9570.68
70_S80_D0.9410.67
83_E87_P0.9250.66
32_I36_A0.9200.65
25_R68_I0.9140.65
36_A39_A0.9010.64
8_G19_L0.8940.63
22_K85_T0.8870.62
43_T52_P0.8660.60
49_P58_A0.8650.60
41_Q44_A0.8610.60
77_N84_E0.8610.60
63_P70_S0.8520.59
19_L23_L0.8440.58
7_G79_F0.8350.58
10_N70_S0.8260.57
80_D84_E0.8230.57
6_G73_L0.8120.55
37_G49_P0.8100.55
40_L58_A0.7940.54
44_A50_A0.7910.54
7_G76_K0.7870.53
6_G17_A0.7690.51
14_Q18_A0.7660.51
10_N72_C0.7620.51
44_A58_A0.7600.51
47_P50_A0.7590.51
63_P66_V0.7590.51
5_D10_N0.7510.50
17_A21_A0.7480.49
12_N64_V0.7460.49
82_A85_T0.7350.48
11_L27_G0.7270.48
24_A75_L0.7250.47
27_G75_L0.7230.47
38_A47_P0.7080.46
42_N51_P0.7070.46
47_P52_P0.6920.44
44_A49_P0.6890.44
19_L79_F0.6770.43
10_N14_Q0.6760.43
78_M81_P0.6710.42
45_A58_A0.6680.42
15_S71_R0.6420.40
37_G42_N0.6370.39
6_G11_L0.6250.38
66_V69_A0.6180.38
34_G39_A0.6120.37
73_L78_M0.6110.37
11_L25_R0.6110.37
38_A46_A0.6030.36
10_N22_K0.5970.36
22_K66_V0.5930.35
21_A73_L0.5920.35
74_L86_E0.5910.35
37_G40_L0.5900.35
47_P51_P0.5880.35
1_L6_G0.5860.35
14_Q27_G0.5830.35
51_P58_A0.5800.34
38_A41_Q0.5750.34
11_L81_P0.5730.34
67_G75_L0.5710.34
5_D13_A0.5680.33
29_G32_I0.5600.33
32_I37_G0.5580.32
39_A48_P0.5490.32
4_D11_L0.5330.30
82_A86_E0.5300.30
46_A57_A0.5140.29
67_G70_S0.5140.29
21_A75_L0.5090.29
24_A71_R0.5070.28
74_L82_A0.5070.28
29_G36_A0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ue2A 1 0.4382 26.7 0.886 Contact Map
2ditA 1 0.382 24.2 0.888 Contact Map
2gqbA 1 0.4045 11.6 0.903 Contact Map
2pv0B 1 0.7865 8 0.91 Contact Map
3dxbA 5 0.8876 2.4 0.93 Contact Map
2adcA 1 0.3596 2 0.933 Contact Map
2khcA 1 0.6404 2 0.934 Contact Map
2ebfX 1 0.6966 1.9 0.934 Contact Map
4f02A 1 0.2022 1.9 0.934 Contact Map
3a6pA 1 0.1124 1.8 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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