GREMLIN Database
BCD - Beta-carotene 15,15'-dioxygenase
PFAM: PF15461 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 268 (261)
Sequences: 2986 (2335)
Seq/√Len: 144.5
META: 0.885

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
171_F179_A4.0301.00
5_L9_P3.9271.00
163_E191_R3.8321.00
211_K215_K3.4201.00
170_L174_L3.3821.00
44_V255_A3.0931.00
224_T227_G2.8331.00
223_L227_G2.7231.00
103_H106_E2.6111.00
63_S67_F2.4641.00
44_V55_A2.3501.00
48_W254_A2.3031.00
45_I255_A2.2731.00
44_V48_W2.2361.00
71_D196_L2.1671.00
176_P192_H2.1451.00
67_F180_F2.1401.00
150_K154_L2.0181.00
144_A148_F2.0041.00
68_G92_G1.9911.00
47_L55_A1.9861.00
102_F172_Y1.9731.00
45_I49_L1.8861.00
13_L196_L1.8481.00
192_H264_V1.8351.00
71_D192_H1.8121.00
18_A22_L1.7261.00
192_H196_L1.6901.00
2_L181_A1.6781.00
62_I261_M1.6541.00
132_L135_L1.6541.00
107_V111_F1.6401.00
98_L102_F1.6391.00
96_L100_L1.6341.00
139_L147_L1.5891.00
65_Y88_Y1.5751.00
228_L252_G1.5711.00
33_F48_W1.5581.00
151_K154_L1.5541.00
7_G11_G1.5521.00
44_V258_L1.5421.00
13_L213_F1.5411.00
235_L248_L1.5221.00
231_L235_L1.5151.00
250_F253_L1.5131.00
93_L97_L1.5021.00
70_G192_H1.4991.00
59_F254_A1.4981.00
256_L261_M1.4971.00
98_L168_L1.4741.00
143_L149_L1.4691.00
217_A221_T1.4541.00
10_H14_D1.4531.00
258_L261_M1.4491.00
173_L176_P1.4381.00
70_G91_R1.4341.00
41_A256_L1.4311.00
71_D183_Y1.4241.00
174_L178_L1.4221.00
44_V254_A1.4181.00
70_G195_R1.4151.00
70_G191_R1.4081.00
115_T119_I1.3991.00
46_L50_L1.3961.00
56_L250_F1.3911.00
261_M265_D1.3811.00
26_K29_S1.3751.00
152_K155_R1.3531.00
141_L146_L1.3161.00
70_G264_V1.3141.00
7_G14_D1.3131.00
15_H33_F1.3081.00
257_T261_M1.3061.00
2_L185_C1.2921.00
140_L144_A1.2921.00
149_L152_K1.2871.00
153_R156_K1.2871.00
7_G10_H1.2841.00
109_E112_A1.2781.00
138_L141_L1.2701.00
53_V57_L1.2641.00
136_L139_L1.2561.00
146_L149_L1.2561.00
146_L152_K1.2531.00
47_L51_F1.2521.00
163_E167_L1.2481.00
56_L114_L1.2481.00
48_W251_I1.2461.00
176_P191_R1.2441.00
145_L148_F1.2321.00
63_S264_V1.2291.00
96_L99_P1.2221.00
217_A220_L1.2131.00
251_I254_A1.2081.00
163_E192_H1.2061.00
123_L126_L1.2011.00
148_F153_R1.2011.00
189_S193_L1.1901.00
32_L36_I1.1791.00
16_L216_K1.1781.00
136_L143_L1.1761.00
142_L152_K1.1721.00
114_L185_C1.1681.00
147_L152_K1.1641.00
56_L111_F1.1521.00
56_L60_L1.1500.99
87_L91_R1.1460.99
139_L152_K1.1420.99
213_F221_T1.1410.99
8_I253_L1.1390.99
255_A261_M1.1390.99
67_F249_I1.1380.99
253_L256_L1.1320.99
170_L182_I1.1220.99
221_T224_T1.1120.99
225_L228_L1.1110.99
247_A251_I1.1110.99
63_S180_F1.1010.99
144_A147_L1.0970.99
92_G254_A1.0960.99
143_L150_K1.0950.99
99_P220_L1.0940.99
48_W71_D1.0910.99
91_R171_F1.0860.99
187_W191_R1.0820.99
141_L149_L1.0780.99
229_L233_Y1.0690.99
137_L142_L1.0690.99
95_I99_P1.0680.99
71_D191_R1.0660.99
169_I173_L1.0660.99
27_K30_L1.0630.99
11_G14_D1.0620.99
143_L147_L1.0590.99
225_L229_L1.0590.99
250_F254_A1.0540.99
137_L151_K1.0540.99
136_L140_L1.0520.99
180_F250_F1.0410.99
140_L143_L1.0340.99
3_I181_A1.0300.99
110_I114_L1.0210.99
192_H257_T1.0190.99
210_L214_L1.0150.99
100_L107_V1.0110.99
142_L147_L1.0110.99
125_L128_L1.0070.99
249_I253_L1.0040.99
142_L150_K0.9970.99
109_E113_L0.9970.99
167_L183_Y0.9940.99
253_L263_L0.9940.99
41_A255_A0.9890.98
128_L132_L0.9810.98
255_A258_L0.9780.98
54_L57_L0.9780.98
69_E176_P0.9780.98
148_F155_R0.9700.98
148_F154_L0.9700.98
71_D256_L0.9680.98
193_L197_I0.9670.98
69_E72_L0.9660.98
111_F114_L0.9630.98
249_I252_G0.9580.98
146_L150_K0.9530.98
66_H188_H0.9470.98
138_L149_L0.9390.98
106_E109_E0.9380.98
60_L96_L0.9320.98
257_T263_L0.9270.98
70_G163_E0.9250.98
67_F250_F0.9190.98
152_K156_K0.9170.98
185_C189_S0.9160.97
124_L128_L0.9160.97
247_A250_F0.9050.97
261_M264_V0.9040.97
148_F152_K0.8990.97
145_L152_K0.8970.97
193_L213_F0.8850.97
105_E109_E0.8760.97
174_L179_A0.8680.97
138_L152_K0.8650.96
144_A154_L0.8650.96
197_I217_A0.8640.96
254_A258_L0.8620.96
64_A89_F0.8510.96
8_I224_T0.8510.96
30_L34_L0.8470.96
139_L150_K0.8460.96
137_L153_R0.8420.96
216_K220_L0.8410.96
187_W193_L0.8330.96
167_L187_W0.8290.95
68_G196_L0.8240.95
224_T231_L0.8220.95
56_L107_V0.8220.95
63_S249_I0.8190.95
110_I250_F0.8190.95
149_L156_K0.8180.95
222_L225_L0.8180.95
99_P176_P0.8160.95
91_R254_A0.8140.95
13_L217_A0.8100.95
176_P256_L0.8100.95
70_G183_Y0.8100.95
142_L149_L0.8070.95
13_L192_H0.8070.95
224_T241_L0.8030.95
138_L144_A0.8000.95
112_A164_L0.8000.95
154_L158_L0.7970.94
120_P161_L0.7930.94
196_L213_F0.7910.94
201_L204_G0.7850.94
143_L148_F0.7850.94
147_L153_R0.7830.94
70_G261_M0.7820.94
114_L250_F0.7720.93
254_A259_P0.7710.93
35_L158_L0.7680.93
125_L130_L0.7680.93
15_H34_L0.7670.93
8_I179_A0.7660.93
147_L151_K0.7660.93
141_L147_L0.7650.93
220_L223_L0.7630.93
99_P171_F0.7580.93
7_G67_F0.7570.93
71_D91_R0.7470.92
248_L252_G0.7440.92
84_R88_Y0.7440.92
228_L232_Y0.7440.92
59_F189_S0.7440.92
144_A153_R0.7420.92
48_W185_C0.7400.92
115_T118_F0.7390.92
64_A96_L0.7360.92
247_A253_L0.7350.92
140_L147_L0.7300.91
6_I33_F0.7290.91
76_L79_K0.7270.91
3_I257_T0.7260.91
181_A185_C0.7260.91
69_E265_D0.7240.91
38_L42_L0.7230.91
13_L17_I0.7230.91
213_F220_L0.7220.91
96_L171_F0.7190.91
153_R157_F0.7180.91
92_G100_L0.7160.91
208_K212_R0.7150.91
155_R159_L0.7140.90
145_L165_L0.7130.90
62_I257_T0.7100.90
113_L246_L0.7080.90
70_G196_L0.7020.90
125_L129_L0.6990.90
8_I256_L0.6970.89
217_A254_A0.6950.89
145_L153_R0.6890.89
138_L153_R0.6880.89
98_L171_F0.6870.89
257_T260_H0.6850.89
45_I251_I0.6820.88
91_R192_H0.6810.88
87_L171_F0.6810.88
34_L220_L0.6800.88
114_L117_L0.6780.88
17_I196_L0.6750.88
3_I254_A0.6740.88
170_L191_R0.6740.88
141_L148_F0.6740.88
91_R187_W0.6740.88
18_A23_K0.6720.88
247_A252_G0.6720.88
29_S32_L0.6700.87
161_L165_L0.6640.87
216_K224_T0.6640.87
136_L149_L0.6630.87
72_L87_L0.6620.87
112_A115_T0.6600.87
35_L140_L0.6580.87
15_H187_W0.6580.87
124_L127_I0.6570.86
69_E91_R0.6530.86
154_L157_F0.6530.86
14_D66_H0.6530.86
54_L58_L0.6520.86
121_A169_I0.6510.86
122_L125_L0.6510.86
91_R163_E0.6500.86
210_L213_F0.6490.86
7_G66_H0.6480.86
140_L150_K0.6460.86
96_L176_P0.6460.86
213_F217_A0.6440.85
2_L175_P0.6420.85
143_L154_L0.6350.85
167_L171_F0.6340.84
143_L155_R0.6340.84
15_H196_L0.6340.84
13_L48_W0.6330.84
91_R95_I0.6320.84
64_A93_L0.6280.84
72_L195_R0.6260.84
138_L150_K0.6240.84
33_F251_I0.6240.84
213_F219_P0.6230.83
130_L135_L0.6210.83
114_L249_I0.6210.83
138_L142_L0.6180.83
104_P121_A0.6180.83
48_W59_F0.6170.83
13_L71_D0.6140.83
263_L266_K0.6130.82
180_F249_I0.6120.82
48_W174_L0.6110.82
52_P59_F0.6110.82
193_L217_A0.6090.82
69_E192_H0.6080.82
137_L144_A0.6070.82
191_R258_L0.6060.82
246_L250_F0.6050.82
176_P261_M0.6050.82
141_L153_R0.6040.82
8_I178_L0.6040.82
254_A257_T0.6020.81
171_F193_L0.6000.81
147_L150_K0.5990.81
29_S38_L0.5990.81
142_L154_L0.5960.81
91_R99_P0.5950.81
208_K211_K0.5940.80
139_L144_A0.5940.80
18_A21_L0.5930.80
72_L189_S0.5900.80
57_L61_L0.5870.80
14_D188_H0.5830.79
136_L151_K0.5780.79
142_L153_R0.5760.78
31_L35_L0.5750.78
7_G188_H0.5730.78
59_F66_H0.5730.78
107_V110_I0.5690.78
154_L159_L0.5680.77
111_F253_L0.5650.77
252_G256_L0.5590.76
148_F156_K0.5540.76
72_L264_V0.5540.76
178_L181_A0.5530.76
65_Y265_D0.5500.75
176_P249_I0.5500.75
141_L152_K0.5490.75
192_H256_L0.5460.75
33_F180_F0.5450.75
48_W55_A0.5430.74
179_A187_W0.5390.74
191_R196_L0.5380.74
90_A93_L0.5360.73
215_K219_P0.5350.73
65_Y69_E0.5350.73
141_L151_K0.5340.73
111_F176_P0.5320.73
131_S135_L0.5310.73
206_L211_K0.5310.73
33_F44_V0.5300.72
113_L247_A0.5290.72
196_L221_T0.5290.72
250_F256_L0.5270.72
48_W250_F0.5250.72
15_H253_L0.5210.71
71_D174_L0.5210.71
136_L144_A0.5210.71
141_L156_K0.5200.71
201_L206_L0.5200.71
60_L110_I0.5190.71
224_T228_L0.5190.71
11_G67_F0.5190.71
13_L16_L0.5170.71
171_F183_Y0.5160.70
149_L157_F0.5150.70
252_G263_L0.5130.70
135_L139_L0.5130.70
252_G258_L0.5120.70
151_K156_K0.5110.70
147_L154_L0.5090.69
176_P264_V0.5060.69
167_L179_A0.5040.69
141_L144_A0.5030.69
220_L254_A0.5010.68
87_L103_H0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yevC 1 0.2052 4.1 0.961 Contact Map
3wajA 1 0.7948 2.2 0.966 Contact Map
2lifA 1 0.1007 2.2 0.967 Contact Map
1rklA 1 0.1343 1.9 0.967 Contact Map
3rlfG 1 0.4104 1.8 0.968 Contact Map
2onkC 2 0.7873 1.5 0.969 Contact Map
2latA 1 0.1381 1.5 0.97 Contact Map
4tquM 1 0.4067 1.3 0.971 Contact Map
3wguB 1 0.2127 1.3 0.971 Contact Map
3tx3A 2 0.2873 1 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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