BCD - PFAM28P - GREMLIN Contacts

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BCD - Beta-carotene 15,15'-dioxygenase

PFAM:	PF15461	Sequences: FLILLIGIPHGALDHLIAKKLLKKKKKKSLLLFLLIYLLLALLVILLWLLFPVLALLLFLLISAYHFGEGDLAGFLILKNSLLRALLYFARGLLILLLPLLFHPEEVAEIFALLTGLFIPALLLLLILLLSLFRLLLLLLLLLALLLFLKKKRLRKFLLELLELLLLLILFYLLPPLLAFAIYFCFWHSIRHLARLILVFLYGGNLKKSLKRFLKKALPLTLLTLLGLLILYYLLPNSYSLDESLLALIFIGLAALTLPHMLLVDKLD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	268 (261)
Sequences:	2986 (2335)
Seq/√Len:	144.5
META:	0.885

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
171_F	179_A	4.030	1.00
5_L	9_P	3.927	1.00
163_E	191_R	3.832	1.00
211_K	215_K	3.420	1.00
170_L	174_L	3.382	1.00
44_V	255_A	3.093	1.00
224_T	227_G	2.833	1.00
223_L	227_G	2.723	1.00
103_H	106_E	2.611	1.00
63_S	67_F	2.464	1.00
44_V	55_A	2.350	1.00
48_W	254_A	2.303	1.00
45_I	255_A	2.273	1.00
44_V	48_W	2.236	1.00
71_D	196_L	2.167	1.00
176_P	192_H	2.145	1.00
67_F	180_F	2.140	1.00
150_K	154_L	2.018	1.00
144_A	148_F	2.004	1.00
68_G	92_G	1.991	1.00
47_L	55_A	1.986	1.00
102_F	172_Y	1.973	1.00
45_I	49_L	1.886	1.00
13_L	196_L	1.848	1.00
192_H	264_V	1.835	1.00
71_D	192_H	1.812	1.00
18_A	22_L	1.726	1.00
192_H	196_L	1.690	1.00
2_L	181_A	1.678	1.00
62_I	261_M	1.654	1.00
132_L	135_L	1.654	1.00
107_V	111_F	1.640	1.00
98_L	102_F	1.639	1.00
96_L	100_L	1.634	1.00
139_L	147_L	1.589	1.00
65_Y	88_Y	1.575	1.00
228_L	252_G	1.571	1.00
33_F	48_W	1.558	1.00
151_K	154_L	1.554	1.00
7_G	11_G	1.552	1.00
44_V	258_L	1.542	1.00
13_L	213_F	1.541	1.00
235_L	248_L	1.522	1.00
231_L	235_L	1.515	1.00
250_F	253_L	1.513	1.00
93_L	97_L	1.502	1.00
70_G	192_H	1.499	1.00
59_F	254_A	1.498	1.00
256_L	261_M	1.497	1.00
98_L	168_L	1.474	1.00
143_L	149_L	1.469	1.00
217_A	221_T	1.454	1.00
10_H	14_D	1.453	1.00
258_L	261_M	1.449	1.00
173_L	176_P	1.438	1.00
70_G	91_R	1.434	1.00
41_A	256_L	1.431	1.00
71_D	183_Y	1.424	1.00
174_L	178_L	1.422	1.00
44_V	254_A	1.418	1.00
70_G	195_R	1.415	1.00
70_G	191_R	1.408	1.00
115_T	119_I	1.399	1.00
46_L	50_L	1.396	1.00
56_L	250_F	1.391	1.00
261_M	265_D	1.381	1.00
26_K	29_S	1.375	1.00
152_K	155_R	1.353	1.00
141_L	146_L	1.316	1.00
70_G	264_V	1.314	1.00
7_G	14_D	1.313	1.00
15_H	33_F	1.308	1.00
257_T	261_M	1.306	1.00
2_L	185_C	1.292	1.00
140_L	144_A	1.292	1.00
149_L	152_K	1.287	1.00
153_R	156_K	1.287	1.00
7_G	10_H	1.284	1.00
109_E	112_A	1.278	1.00
138_L	141_L	1.270	1.00
53_V	57_L	1.264	1.00
136_L	139_L	1.256	1.00
146_L	149_L	1.256	1.00
146_L	152_K	1.253	1.00
47_L	51_F	1.252	1.00
163_E	167_L	1.248	1.00
56_L	114_L	1.248	1.00
48_W	251_I	1.246	1.00
176_P	191_R	1.244	1.00
145_L	148_F	1.232	1.00
63_S	264_V	1.229	1.00
96_L	99_P	1.222	1.00
217_A	220_L	1.213	1.00
251_I	254_A	1.208	1.00
163_E	192_H	1.206	1.00
123_L	126_L	1.201	1.00
148_F	153_R	1.201	1.00
189_S	193_L	1.190	1.00
32_L	36_I	1.179	1.00
16_L	216_K	1.178	1.00
136_L	143_L	1.176	1.00
142_L	152_K	1.172	1.00
114_L	185_C	1.168	1.00
147_L	152_K	1.164	1.00
56_L	111_F	1.152	1.00
56_L	60_L	1.150	0.99
87_L	91_R	1.146	0.99
139_L	152_K	1.142	0.99
213_F	221_T	1.141	0.99
8_I	253_L	1.139	0.99
255_A	261_M	1.139	0.99
67_F	249_I	1.138	0.99
253_L	256_L	1.132	0.99
170_L	182_I	1.122	0.99
221_T	224_T	1.112	0.99
225_L	228_L	1.111	0.99
247_A	251_I	1.111	0.99
63_S	180_F	1.101	0.99
144_A	147_L	1.097	0.99
92_G	254_A	1.096	0.99
143_L	150_K	1.095	0.99
99_P	220_L	1.094	0.99
48_W	71_D	1.091	0.99
91_R	171_F	1.086	0.99
187_W	191_R	1.082	0.99
141_L	149_L	1.078	0.99
229_L	233_Y	1.069	0.99
137_L	142_L	1.069	0.99
95_I	99_P	1.068	0.99
71_D	191_R	1.066	0.99
169_I	173_L	1.066	0.99
27_K	30_L	1.063	0.99
11_G	14_D	1.062	0.99
143_L	147_L	1.059	0.99
225_L	229_L	1.059	0.99
250_F	254_A	1.054	0.99
137_L	151_K	1.054	0.99
136_L	140_L	1.052	0.99
180_F	250_F	1.041	0.99
140_L	143_L	1.034	0.99
3_I	181_A	1.030	0.99
110_I	114_L	1.021	0.99
192_H	257_T	1.019	0.99
210_L	214_L	1.015	0.99
100_L	107_V	1.011	0.99
142_L	147_L	1.011	0.99
125_L	128_L	1.007	0.99
249_I	253_L	1.004	0.99
142_L	150_K	0.997	0.99
109_E	113_L	0.997	0.99
167_L	183_Y	0.994	0.99
253_L	263_L	0.994	0.99
41_A	255_A	0.989	0.98
128_L	132_L	0.981	0.98
255_A	258_L	0.978	0.98
54_L	57_L	0.978	0.98
69_E	176_P	0.978	0.98
148_F	155_R	0.970	0.98
148_F	154_L	0.970	0.98
71_D	256_L	0.968	0.98
193_L	197_I	0.967	0.98
69_E	72_L	0.966	0.98
111_F	114_L	0.963	0.98
249_I	252_G	0.958	0.98
146_L	150_K	0.953	0.98
66_H	188_H	0.947	0.98
138_L	149_L	0.939	0.98
106_E	109_E	0.938	0.98
60_L	96_L	0.932	0.98
257_T	263_L	0.927	0.98
70_G	163_E	0.925	0.98
67_F	250_F	0.919	0.98
152_K	156_K	0.917	0.98
185_C	189_S	0.916	0.97
124_L	128_L	0.916	0.97
247_A	250_F	0.905	0.97
261_M	264_V	0.904	0.97
148_F	152_K	0.899	0.97
145_L	152_K	0.897	0.97
193_L	213_F	0.885	0.97
105_E	109_E	0.876	0.97
174_L	179_A	0.868	0.97
138_L	152_K	0.865	0.96
144_A	154_L	0.865	0.96
197_I	217_A	0.864	0.96
254_A	258_L	0.862	0.96
64_A	89_F	0.851	0.96
8_I	224_T	0.851	0.96
30_L	34_L	0.847	0.96
139_L	150_K	0.846	0.96
137_L	153_R	0.842	0.96
216_K	220_L	0.841	0.96
187_W	193_L	0.833	0.96
167_L	187_W	0.829	0.95
68_G	196_L	0.824	0.95
224_T	231_L	0.822	0.95
56_L	107_V	0.822	0.95
63_S	249_I	0.819	0.95
110_I	250_F	0.819	0.95
149_L	156_K	0.818	0.95
222_L	225_L	0.818	0.95
99_P	176_P	0.816	0.95
91_R	254_A	0.814	0.95
13_L	217_A	0.810	0.95
176_P	256_L	0.810	0.95
70_G	183_Y	0.810	0.95
142_L	149_L	0.807	0.95
13_L	192_H	0.807	0.95
224_T	241_L	0.803	0.95
138_L	144_A	0.800	0.95
112_A	164_L	0.800	0.95
154_L	158_L	0.797	0.94
120_P	161_L	0.793	0.94
196_L	213_F	0.791	0.94
201_L	204_G	0.785	0.94
143_L	148_F	0.785	0.94
147_L	153_R	0.783	0.94
70_G	261_M	0.782	0.94
114_L	250_F	0.772	0.93
254_A	259_P	0.771	0.93
35_L	158_L	0.768	0.93
125_L	130_L	0.768	0.93
15_H	34_L	0.767	0.93
8_I	179_A	0.766	0.93
147_L	151_K	0.766	0.93
141_L	147_L	0.765	0.93
220_L	223_L	0.763	0.93
99_P	171_F	0.758	0.93
7_G	67_F	0.757	0.93
71_D	91_R	0.747	0.92
248_L	252_G	0.744	0.92
84_R	88_Y	0.744	0.92
228_L	232_Y	0.744	0.92
59_F	189_S	0.744	0.92
144_A	153_R	0.742	0.92
48_W	185_C	0.740	0.92
115_T	118_F	0.739	0.92
64_A	96_L	0.736	0.92
247_A	253_L	0.735	0.92
140_L	147_L	0.730	0.91
6_I	33_F	0.729	0.91
76_L	79_K	0.727	0.91
3_I	257_T	0.726	0.91
181_A	185_C	0.726	0.91
69_E	265_D	0.724	0.91
38_L	42_L	0.723	0.91
13_L	17_I	0.723	0.91
213_F	220_L	0.722	0.91
96_L	171_F	0.719	0.91
153_R	157_F	0.718	0.91
92_G	100_L	0.716	0.91
208_K	212_R	0.715	0.91
155_R	159_L	0.714	0.90
145_L	165_L	0.713	0.90
62_I	257_T	0.710	0.90
113_L	246_L	0.708	0.90
70_G	196_L	0.702	0.90
125_L	129_L	0.699	0.90
8_I	256_L	0.697	0.89
217_A	254_A	0.695	0.89
145_L	153_R	0.689	0.89
138_L	153_R	0.688	0.89
98_L	171_F	0.687	0.89
257_T	260_H	0.685	0.89
45_I	251_I	0.682	0.88
91_R	192_H	0.681	0.88
87_L	171_F	0.681	0.88
34_L	220_L	0.680	0.88
114_L	117_L	0.678	0.88
17_I	196_L	0.675	0.88
3_I	254_A	0.674	0.88
170_L	191_R	0.674	0.88
141_L	148_F	0.674	0.88
91_R	187_W	0.674	0.88
18_A	23_K	0.672	0.88
247_A	252_G	0.672	0.88
29_S	32_L	0.670	0.87
161_L	165_L	0.664	0.87
216_K	224_T	0.664	0.87
136_L	149_L	0.663	0.87
72_L	87_L	0.662	0.87
112_A	115_T	0.660	0.87
35_L	140_L	0.658	0.87
15_H	187_W	0.658	0.87
124_L	127_I	0.657	0.86
69_E	91_R	0.653	0.86
154_L	157_F	0.653	0.86
14_D	66_H	0.653	0.86
54_L	58_L	0.652	0.86
121_A	169_I	0.651	0.86
122_L	125_L	0.651	0.86
91_R	163_E	0.650	0.86
210_L	213_F	0.649	0.86
7_G	66_H	0.648	0.86
140_L	150_K	0.646	0.86
96_L	176_P	0.646	0.86
213_F	217_A	0.644	0.85
2_L	175_P	0.642	0.85
143_L	154_L	0.635	0.85
167_L	171_F	0.634	0.84
143_L	155_R	0.634	0.84
15_H	196_L	0.634	0.84
13_L	48_W	0.633	0.84
91_R	95_I	0.632	0.84
64_A	93_L	0.628	0.84
72_L	195_R	0.626	0.84
138_L	150_K	0.624	0.84
33_F	251_I	0.624	0.84
213_F	219_P	0.623	0.83
130_L	135_L	0.621	0.83
114_L	249_I	0.621	0.83
138_L	142_L	0.618	0.83
104_P	121_A	0.618	0.83
48_W	59_F	0.617	0.83
13_L	71_D	0.614	0.83
263_L	266_K	0.613	0.82
180_F	249_I	0.612	0.82
48_W	174_L	0.611	0.82
52_P	59_F	0.611	0.82
193_L	217_A	0.609	0.82
69_E	192_H	0.608	0.82
137_L	144_A	0.607	0.82
191_R	258_L	0.606	0.82
246_L	250_F	0.605	0.82
176_P	261_M	0.605	0.82
141_L	153_R	0.604	0.82
8_I	178_L	0.604	0.82
254_A	257_T	0.602	0.81
171_F	193_L	0.600	0.81
147_L	150_K	0.599	0.81
29_S	38_L	0.599	0.81
142_L	154_L	0.596	0.81
91_R	99_P	0.595	0.81
208_K	211_K	0.594	0.80
139_L	144_A	0.594	0.80
18_A	21_L	0.593	0.80
72_L	189_S	0.590	0.80
57_L	61_L	0.587	0.80
14_D	188_H	0.583	0.79
136_L	151_K	0.578	0.79
142_L	153_R	0.576	0.78
31_L	35_L	0.575	0.78
7_G	188_H	0.573	0.78
59_F	66_H	0.573	0.78
107_V	110_I	0.569	0.78
154_L	159_L	0.568	0.77
111_F	253_L	0.565	0.77
252_G	256_L	0.559	0.76
148_F	156_K	0.554	0.76
72_L	264_V	0.554	0.76
178_L	181_A	0.553	0.76
65_Y	265_D	0.550	0.75
176_P	249_I	0.550	0.75
141_L	152_K	0.549	0.75
192_H	256_L	0.546	0.75
33_F	180_F	0.545	0.75
48_W	55_A	0.543	0.74
179_A	187_W	0.539	0.74
191_R	196_L	0.538	0.74
90_A	93_L	0.536	0.73
215_K	219_P	0.535	0.73
65_Y	69_E	0.535	0.73
141_L	151_K	0.534	0.73
111_F	176_P	0.532	0.73
131_S	135_L	0.531	0.73
206_L	211_K	0.531	0.73
33_F	44_V	0.530	0.72
113_L	247_A	0.529	0.72
196_L	221_T	0.529	0.72
250_F	256_L	0.527	0.72
48_W	250_F	0.525	0.72
15_H	253_L	0.521	0.71
71_D	174_L	0.521	0.71
136_L	144_A	0.521	0.71
141_L	156_K	0.520	0.71
201_L	206_L	0.520	0.71
60_L	110_I	0.519	0.71
224_T	228_L	0.519	0.71
11_G	67_F	0.519	0.71
13_L	16_L	0.517	0.71
171_F	183_Y	0.516	0.70
149_L	157_F	0.515	0.70
252_G	263_L	0.513	0.70
135_L	139_L	0.513	0.70
252_G	258_L	0.512	0.70
151_K	156_K	0.511	0.70
147_L	154_L	0.509	0.69
176_P	264_V	0.506	0.69
167_L	179_A	0.504	0.69
141_L	144_A	0.503	0.69
220_L	254_A	0.501	0.68
87_L	103_H	0.500	0.68

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2yevC	1	0.2052	4.1	0.961	Contact Map
3wajA	1	0.7948	2.2	0.966	Contact Map
2lifA	1	0.1007	2.2	0.967	Contact Map
1rklA	1	0.1343	1.9	0.967	Contact Map
3rlfG	1	0.4104	1.8	0.968	Contact Map
2onkC	2	0.7873	1.5	0.969	Contact Map
2latA	1	0.1381	1.5	0.97	Contact Map
4tquM	1	0.4067	1.3	0.971	Contact Map
3wguB	1	0.2127	1.3	0.971	Contact Map
3tx3A	2	0.2873	1	0.973	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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