GREMLIN Database
PGBA_N - Plasminogen-binding protein pgbA N-terminal
PFAM: PF15436 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 217 (213)
Sequences: 599 (492)
Seq/√Len: 33.7
META: 0.866

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_V84_V6.4981.00
142_A163_C5.0641.00
117_H188_R4.4741.00
152_I161_L4.2151.00
157_K171_K3.5291.00
128_E140_K2.9911.00
107_T115_W2.9611.00
6_I14_A2.8911.00
3_K83_K2.8041.00
99_N165_S2.7941.00
25_V49_I2.7831.00
6_I78_P2.6631.00
93_A113_K2.5411.00
208_D211_P2.4901.00
99_N178_P2.4651.00
46_A60_L2.4461.00
27_M87_G2.4020.99
13_N57_T2.1760.99
26_G29_G2.1750.99
97_A103_Y2.1310.99
11_G15_T1.8970.97
133_P192_I1.8960.97
22_N25_V1.8690.97
131_P192_I1.8630.97
44_A78_P1.8610.97
48_V86_L1.8450.97
45_R164_I1.8400.97
121_F141_F1.7880.96
95_L107_T1.7560.96
130_H137_D1.7450.95
64_D143_K1.7420.95
150_I163_C1.7350.95
47_V165_S1.7110.95
140_K144_K1.7050.95
154_L159_Y1.6770.94
35_Y76_T1.6760.94
62_P96_I1.6630.94
43_I142_A1.6090.93
110_Y151_F1.6030.93
64_D139_Q1.5960.93
72_P188_R1.5930.93
157_K173_D1.5920.92
68_Q163_C1.5730.92
86_L131_P1.5630.92
99_N102_T1.5240.91
6_I9_V1.5170.91
106_I115_W1.5160.90
154_L161_L1.4910.90
159_Y166_F1.4750.89
68_Q142_A1.4340.88
161_L217_L1.4000.87
50_S157_K1.3850.86
69_D180_K1.3750.86
27_M160_L1.3650.85
8_S31_V1.3590.85
115_W196_W1.3290.84
48_V58_L1.3090.83
50_S116_I1.3030.82
25_V50_S1.2690.81
149_L160_L1.2680.81
8_S15_T1.2640.80
90_Y149_L1.2500.80
131_P186_Y1.2490.79
23_I27_M1.2360.79
43_I163_C1.2350.79
213_Y217_L1.1990.77
92_R138_F1.1940.76
161_L166_F1.1850.76
106_I153_V1.1780.75
159_Y168_I1.1770.75
170_S186_Y1.1750.75
213_Y216_L1.1750.75
9_V80_V1.1710.75
86_L90_Y1.1610.74
38_G47_V1.1400.73
66_L137_D1.1350.73
187_T190_E1.1170.71
172_K197_F1.1160.71
113_K149_L1.1070.71
136_E156_N1.0820.69
6_I16_I1.0720.68
103_Y165_S1.0660.68
59_K168_I1.0570.67
99_N177_L1.0410.66
51_K56_A1.0290.65
182_Q204_S1.0220.64
43_I76_T1.0200.64
196_W201_F1.0150.64
200_G203_S1.0140.64
108_K111_K1.0130.64
117_H186_Y1.0110.64
54_G57_T1.0080.63
105_K172_K1.0080.63
30_I156_N1.0060.63
184_P188_R0.9980.62
166_F169_L0.9970.62
63_F135_K0.9820.61
196_W200_G0.9800.61
53_G59_K0.9780.61
48_V131_P0.9720.60
10_D13_N0.9700.60
34_N55_I0.9630.60
103_Y138_F0.9610.60
96_I138_F0.9610.60
9_V197_F0.9560.59
49_I58_L0.9400.58
92_R146_S0.9390.58
4_T186_Y0.9330.57
195_G205_E0.9320.57
129_G194_S0.9310.57
151_F189_V0.9230.56
121_F137_D0.9220.56
11_G208_D0.9210.56
109_S150_I0.9210.56
46_A58_L0.9180.56
49_I161_L0.9150.56
177_L186_Y0.9040.55
43_I74_I0.8900.54
149_L184_P0.8900.54
122_A192_I0.8880.53
86_L96_I0.8850.53
80_V83_K0.8830.53
118_P189_V0.8740.52
115_W118_P0.8730.52
61_S187_T0.8660.52
181_A189_V0.8660.52
62_P77_K0.8660.52
21_K54_G0.8640.51
126_S131_P0.8630.51
42_I110_Y0.8610.51
16_I19_N0.8590.51
52_D96_I0.8580.51
67_K70_A0.8530.51
5_P17_T0.8520.50
194_S211_P0.8460.50
207_G212_Y0.8430.50
74_I87_G0.8420.50
34_N40_S0.8370.49
15_T58_L0.8350.49
72_P117_H0.8350.49
206_I210_Y0.8320.49
9_V202_G0.8310.49
206_I211_P0.8300.49
14_A80_V0.8290.49
88_Y126_S0.8240.48
110_Y158_L0.8090.47
86_L160_L0.8080.47
71_L191_K0.8060.47
49_I173_D0.7970.46
50_S150_I0.7970.46
10_D108_K0.7930.46
41_A161_L0.7910.45
62_P78_P0.7850.45
179_K182_Q0.7810.45
116_I191_K0.7790.44
134_T153_V0.7770.44
31_V46_A0.7760.44
53_G208_D0.7760.44
203_S215_E0.7730.44
66_L70_A0.7700.44
42_I63_F0.7700.44
177_L191_K0.7670.43
91_N113_K0.7620.43
125_L184_P0.7570.43
207_G215_E0.7560.42
44_A124_Y0.7560.42
7_L16_I0.7560.42
95_L190_E0.7510.42
3_K8_S0.7500.42
158_L172_K0.7330.41
40_S57_T0.7320.40
170_S173_D0.7310.40
42_I151_F0.7250.40
93_A141_F0.7230.40
125_L151_F0.7210.40
70_A166_F0.7200.40
117_H184_P0.7190.39
163_C187_T0.7180.39
95_L106_I0.7180.39
100_E186_Y0.7180.39
46_A84_V0.7170.39
34_N83_K0.7140.39
8_S16_I0.7100.39
32_V190_E0.7080.39
6_I80_V0.7080.39
65_A76_T0.7070.38
138_F146_S0.7070.38
99_N193_D0.7050.38
6_I111_K0.6990.38
77_K136_E0.6980.38
42_I45_R0.6980.38
112_N120_L0.6960.38
2_I97_A0.6920.37
11_G14_A0.6890.37
122_A130_H0.6890.37
14_A60_L0.6880.37
183_L206_I0.6870.37
45_R61_S0.6830.37
118_P167_K0.6810.36
8_S165_S0.6780.36
154_L157_K0.6780.36
106_I204_S0.6760.36
207_G210_Y0.6720.36
158_L169_L0.6660.35
33_H94_L0.6660.35
14_A152_I0.6650.35
50_S53_G0.6640.35
23_I88_Y0.6630.35
9_V133_P0.6620.35
102_T178_P0.6610.35
77_K155_K0.6590.35
125_L192_I0.6580.35
27_M51_K0.6580.35
70_A168_I0.6540.34
3_K9_V0.6520.34
182_Q192_I0.6500.34
112_N118_P0.6450.34
77_K108_K0.6430.34
96_I169_L0.6420.33
207_G211_P0.6400.33
47_V152_I0.6400.33
6_I180_K0.6390.33
194_S204_S0.6370.33
35_Y43_I0.6360.33
154_L158_L0.6300.33
121_F132_T0.6300.33
45_R193_D0.6280.32
131_P189_V0.6260.32
135_K181_A0.6220.32
7_L17_T0.6200.32
101_E104_A0.6170.32
56_A113_K0.6150.31
93_A115_W0.6130.31
78_P142_A0.6040.31
98_P102_T0.6040.31
210_Y217_L0.6040.31
128_E176_L0.6010.30
95_L161_L0.6010.30
80_V84_V0.6000.30
132_T192_I0.6000.30
139_Q164_I0.6000.30
15_T52_D0.6000.30
60_L99_N0.5960.30
87_G90_Y0.5940.30
195_G204_S0.5920.30
134_T194_S0.5910.30
4_T13_N0.5910.30
162_D165_S0.5900.30
211_P215_E0.5880.30
106_I158_L0.5870.29
54_G123_A0.5870.29
87_G153_V0.5870.29
77_K135_K0.5830.29
147_V158_L0.5820.29
109_S204_S0.5810.29
120_L186_Y0.5800.29
10_D80_V0.5790.29
141_F147_V0.5790.29
71_L108_K0.5780.29
93_A166_F0.5770.29
130_H134_T0.5750.29
70_A161_L0.5730.28
95_L180_K0.5730.28
38_G152_I0.5720.28
27_M86_L0.5680.28
76_T87_G0.5670.28
86_L166_F0.5670.28
132_T206_I0.5670.28
93_A96_I0.5630.28
68_Q123_A0.5630.28
53_G108_K0.5610.28
126_S192_I0.5570.27
4_T203_S0.5570.27
94_L128_E0.5560.27
140_K143_K0.5540.27
113_K146_S0.5520.27
122_A187_T0.5520.27
87_G160_L0.5510.27
142_A164_I0.5490.27
54_G59_K0.5470.27
58_L196_W0.5470.27
33_H72_P0.5460.27
46_A190_E0.5460.27
141_F145_Y0.5460.27
65_A106_I0.5450.27
197_F204_S0.5410.26
194_S200_G0.5400.26
85_I138_F0.5390.26
9_V136_E0.5390.26
32_V64_D0.5380.26
2_I147_V0.5370.26
89_L160_L0.5370.26
102_T106_I0.5350.26
14_A17_T0.5350.26
83_K167_K0.5350.26
210_Y213_Y0.5340.26
28_S98_P0.5340.26
113_K160_L0.5310.26
84_V103_Y0.5300.26
77_K110_Y0.5280.25
131_P206_I0.5270.25
6_I60_L0.5250.25
96_I147_V0.5230.25
6_I10_D0.5220.25
118_P188_R0.5200.25
135_K174_A0.5200.25
203_S206_I0.5140.25
27_M115_W0.5140.25
93_A151_F0.5130.25
12_N57_T0.5120.24
99_N202_G0.5120.24
66_L127_K0.5110.24
99_N175_P0.5100.24
160_L172_K0.5080.24
46_A49_I0.5080.24
90_Y94_L0.5070.24
92_R186_Y0.5020.24
66_L153_V0.5010.24
9_V38_G0.5010.24
37_N77_K0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gz8A 2 0.447 19.8 0.961 Contact Map
1q47A 2 0.4562 10.2 0.966 Contact Map
3w1eA 1 0.3687 7.3 0.968 Contact Map
4xl8A 3 0.7005 4.9 0.971 Contact Map
1kacA 3 0.7235 4.1 0.972 Contact Map
2wstA 3 0.7143 4 0.972 Contact Map
2bzvA 3 0.5991 3.7 0.972 Contact Map
4qq6A 1 0.2396 3.3 0.973 Contact Map
1qiuA 3 0.7235 2.9 0.974 Contact Map
1ah9A 1 0.3226 2.8 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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