GREMLIN Database
SVWC - Single domain von Willebrand factor type C
PFAM: PF15430 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 66 (65)
Sequences: 569 (490)
Seq/√Len: 60.8
META: 0.077

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_D55_K3.7541.00
46_C66_C3.0511.00
10_K13_E2.6611.00
36_G57_Y2.5701.00
25_T35_E2.5421.00
16_K23_R2.3911.00
5_G8_T1.9571.00
27_N33_T1.8831.00
17_L20_P1.8521.00
25_T33_T1.7410.99
23_R35_E1.6420.99
36_G39_P1.6150.99
58_P61_C1.4900.98
35_E38_G1.4650.98
21_C37_C1.4300.98
7_L15_W1.4110.97
24_W34_I1.3850.97
42_L46_C1.3710.97
22_E36_G1.3080.96
14_T23_R1.3050.96
14_T25_T1.1890.93
41_A47_K1.1750.93
47_K65_V1.1740.92
21_C26_C1.1120.90
26_C37_C1.1120.90
21_C60_C1.1000.90
37_C60_C1.1000.90
2_Y5_G1.0580.88
18_P34_I1.0310.87
28_A59_D0.9930.84
37_C58_P0.9830.84
21_C58_P0.9830.84
44_P64_Y0.9280.80
1_C5_G0.9250.80
1_C26_C0.9240.80
32_L55_K0.9120.79
27_N38_G0.9100.79
37_C61_C0.9070.79
21_C61_C0.9070.79
27_N30_G0.8960.78
23_R39_P0.8860.77
24_W29_D0.8740.76
17_L24_W0.8660.75
27_N35_E0.8490.74
14_T40_V0.8430.73
31_T59_D0.8420.73
45_G53_P0.8410.73
3_Y24_W0.8350.73
7_L17_L0.8300.72
19_G54_S0.8250.72
48_L62_P0.8100.70
2_Y8_T0.7970.69
11_P30_G0.7770.67
16_K56_P0.7730.67
2_Y7_L0.7670.66
26_C60_C0.7620.66
29_D43_P0.7550.65
1_C21_C0.7530.65
1_C37_C0.7530.65
46_C51_Y0.7390.63
20_P24_W0.7350.63
50_P62_P0.7330.63
18_P55_K0.7180.61
48_L63_K0.7080.60
8_T34_I0.7020.59
49_V62_P0.6940.58
56_P59_D0.6770.57
14_T31_T0.6690.56
49_V65_V0.6640.55
3_Y32_L0.6630.55
5_G36_G0.6580.54
1_C4_E0.6440.53
47_K59_D0.6430.53
18_P56_P0.6420.53
3_Y40_V0.6170.50
19_G47_K0.6070.49
41_A45_G0.5870.46
3_Y34_I0.5730.45
60_C66_C0.5720.45
10_K62_P0.5710.45
4_E9_L0.5650.44
43_P50_P0.5600.43
44_P56_P0.5540.43
5_G20_P0.5520.42
39_P57_Y0.5480.42
26_C58_P0.5430.41
26_C61_C0.5410.41
61_C66_C0.5380.41
27_N31_T0.5370.41
16_K22_E0.5360.41
19_G52_D0.5350.41
22_E45_G0.5310.40
9_L13_E0.5190.39
16_K64_Y0.5140.38
32_L44_P0.5120.38
4_E24_W0.5110.38
3_Y22_E0.5020.37
28_A38_G0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1u5mA 1 0.8182 62.1 0.731 Contact Map
2mhpA 1 0.5455 16.8 0.804 Contact Map
3bk3C 1 0.8182 5.1 0.845 Contact Map
2cg7A 1 0.5909 4.5 0.85 Contact Map
1r02A 1 0.1818 2.7 0.865 Contact Map
2lzyA 1 0.3485 2.5 0.867 Contact Map
1xhhA 1 0.8485 2.2 0.872 Contact Map
1c4eA 1 0.3485 2.1 0.873 Contact Map
3ix0A 2 0.8485 2 0.874 Contact Map
2rl0A 1 0.5758 1.5 0.883 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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