GREMLIN Database
Imm26 - Immunity protein 26
PFAM: PF15428 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 102 (91)
Sequences: 2278 (1989)
Seq/√Len: 208.5
META: 0.843

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_D76_N3.6471.00
8_A42_P3.3251.00
7_F19_G3.1661.00
15_G38_R3.0821.00
18_F39_S3.0441.00
8_A18_F2.7941.00
20_R33_Y2.4871.00
42_P72_P2.4251.00
81_D84_E2.3131.00
20_R35_F1.9641.00
12_P15_G1.8801.00
16_Y42_P1.7981.00
2_K76_N1.7321.00
45_D48_E1.7281.00
9_I17_A1.6631.00
61_V64_L1.6591.00
36_D53_P1.6201.00
62_D65_G1.6151.00
8_A72_P1.6061.00
6_I77_R1.5861.00
22_L33_Y1.4631.00
85_W88_P1.3941.00
7_F66_L1.3881.00
7_F73_I1.3751.00
11_L17_A1.3701.00
8_A16_Y1.3431.00
19_G34_F1.3411.00
6_I20_R1.3271.00
55_L58_P1.2491.00
46_L49_L1.2091.00
33_Y54_L1.2071.00
9_I34_F1.1681.00
20_R77_R1.1501.00
15_G40_D1.1421.00
43_D48_E1.1171.00
32_V61_V1.1041.00
82_R85_W1.0981.00
11_L14_G1.0951.00
3_E82_R1.0861.00
19_G73_I1.0731.00
8_A39_S1.0451.00
48_E51_K0.9971.00
6_I50_L0.9711.00
45_D51_K0.9551.00
17_A38_R0.9490.99
84_E88_P0.9450.99
37_P52_S0.9250.99
47_E50_L0.9030.99
44_P47_E0.9000.99
66_L73_I0.8730.99
61_V65_G0.8650.99
3_E23_R0.8630.99
64_L68_K0.8510.99
87_P91_G0.8490.99
88_P91_G0.8450.99
24_D27_K0.8370.99
2_K5_D0.8360.99
19_G66_L0.8350.99
20_R76_N0.8330.99
6_I74_I0.8300.99
82_R88_P0.8290.99
56_F60_V0.8270.99
26_P29_G0.8180.98
55_L60_V0.8140.98
56_F59_I0.8050.98
6_I18_F0.7930.98
35_F80_W0.7900.98
17_A37_P0.7870.98
46_L75_G0.7820.98
44_P48_E0.7800.98
57_P61_V0.7710.98
83_E86_P0.7480.97
59_I65_G0.7480.97
54_L58_P0.7460.97
62_D67_T0.7460.97
25_D28_G0.7330.97
65_G70_R0.7290.97
83_E88_P0.7280.97
51_K77_R0.7210.97
60_V63_D0.7200.97
29_G34_F0.7110.96
10_P71_W0.7070.96
8_A74_I0.6900.96
39_S48_E0.6900.96
11_L15_G0.6880.96
9_I16_Y0.6860.95
60_V64_L0.6840.95
2_K12_P0.6780.95
13_D38_R0.6680.95
22_L79_L0.6630.95
13_D40_D0.6570.94
37_P48_E0.6560.94
24_D68_K0.6540.94
22_L85_W0.6520.94
86_P89_S0.6430.94
36_D52_S0.6420.94
10_P17_A0.6290.93
84_E87_P0.6210.92
23_R28_G0.6180.92
20_R80_W0.6090.92
46_L50_L0.6060.92
56_F63_D0.6010.91
24_D28_G0.5970.91
44_P49_L0.5920.91
5_D73_I0.5870.90
62_D66_L0.5850.90
60_V65_G0.5780.90
33_Y36_D0.5690.89
21_V66_L0.5650.88
7_F32_V0.5650.88
29_G60_V0.5620.88
54_L60_V0.5570.88
21_V30_L0.5540.87
57_P60_V0.5510.87
56_F61_V0.5500.87
32_V36_D0.5500.87
45_D49_L0.5430.86
3_E14_G0.5430.86
56_F64_L0.5420.86
81_D85_W0.5400.86
54_L61_V0.5390.86
47_E75_G0.5340.86
44_P75_G0.5310.85
53_P85_W0.5290.85
30_L61_V0.5210.84
25_D31_L0.5200.84
41_E48_E0.5180.84
32_V35_F0.5160.84
43_D51_K0.5150.83
25_D57_P0.5120.83
43_D47_E0.5090.83
64_L70_R0.5070.82
85_W90_F0.5050.82
21_V62_D0.5030.82
21_V33_Y0.5030.82
34_F38_R0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2m0oA 1 0.5098 38.4 0.838 Contact Map
1vu2E 1 0 36.3 0.84 Contact Map
2equA 1 0.6373 35.5 0.84 Contact Map
4qq6A 1 0.5294 32.8 0.843 Contact Map
2xk0A 1 0.5294 31.6 0.845 Contact Map
2e5qA 1 0.5392 29.2 0.847 Contact Map
2d9tA 1 0.6569 28.3 0.848 Contact Map
3p8dA 2 0.5 28.3 0.848 Contact Map
3s6wA 1 0.4804 27.5 0.85 Contact Map
4a4fA 1 0.5294 26 0.851 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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