GREMLIN Database
Abhydrolase_9_N - Alpha/beta-hydrolase family N-terminus
PFAM: PF15420 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 209 (208)
Sequences: 2514 (1866)
Seq/√Len: 129.4
META: 0.71

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
193_S196_S6.7321.00
197_L205_V3.8381.00
157_A161_A3.3611.00
200_Q203_R3.3111.00
184_R208_G3.2581.00
172_T175_G2.9531.00
76_N79_R2.5641.00
173_E203_R2.4391.00
30_L33_W2.4331.00
154_V158_L2.3361.00
54_L58_V2.3181.00
78_I82_M2.1771.00
79_R87_V2.1601.00
115_R119_F2.1071.00
80_A86_P2.1031.00
119_F123_L2.0411.00
156_G160_A2.0001.00
76_N87_V1.9491.00
24_G28_G1.9101.00
146_W150_N1.9091.00
36_R43_R1.8911.00
10_W94_L1.8831.00
113_L145_F1.8171.00
9_G12_F1.8131.00
181_S187_S1.8051.00
182_P187_S1.7871.00
21_A103_F1.7521.00
110_G114_R1.7091.00
123_L127_F1.6941.00
14_G98_V1.6791.00
77_S80_A1.6761.00
72_A76_N1.6661.00
47_R51_R1.6551.00
72_A91_D1.6451.00
26_G110_G1.6401.00
157_A160_A1.6391.00
123_L126_R1.6321.00
89_T92_P1.6181.00
19_I106_L1.5941.00
143_V147_L1.5921.00
22_A26_G1.5681.00
132_V135_V1.5561.00
168_V200_Q1.5381.00
198_G201_G1.5361.00
51_R54_L1.5311.00
121_A137_G1.5271.00
11_L16_L1.5261.00
130_R134_R1.5071.00
50_R54_L1.4851.00
183_L187_S1.4731.00
14_G18_G1.4531.00
128_L132_V1.4431.00
125_G133_A1.4281.00
141_V145_F1.4261.00
107_L111_R1.4161.00
35_W41_L1.4131.00
18_G22_A1.4031.00
113_L141_V1.3971.00
147_L150_N1.3871.00
172_T176_V1.3831.00
137_G141_V1.3601.00
91_D94_L1.3471.00
112_L116_L1.3141.00
87_V91_D1.3091.00
38_L135_V1.3081.00
155_R159_R1.2961.00
4_S12_F1.2861.00
53_W56_L1.2731.00
17_S99_A1.2711.00
148_L152_V1.2671.00
13_Q17_S1.2661.00
88_D91_D1.2461.00
32_A36_R1.2461.00
10_W98_V1.2391.00
22_A107_L1.2261.00
49_R53_W1.2231.00
128_L136_V1.2181.00
53_W57_A1.2030.99
51_R55_V1.1950.99
201_G204_F1.1930.99
121_A125_G1.1920.99
112_L115_R1.1750.99
14_G99_A1.1680.99
186_G191_L1.1640.99
113_L117_V1.1620.99
125_G130_R1.1610.99
197_L202_R1.1600.99
39_E130_R1.1580.99
62_V66_L1.1540.99
171_L199_R1.1460.99
125_G134_R1.1160.99
54_L57_A1.1140.99
75_Q78_I1.1140.99
103_F107_L1.1110.99
176_V203_R1.0930.99
39_E42_P1.0930.99
45_S48_A1.0670.99
117_V121_A1.0630.99
67_F71_A1.0480.98
72_A89_T1.0420.98
95_V98_V1.0410.98
134_R137_G1.0400.98
124_L127_F1.0350.98
16_L21_A1.0340.98
105_L109_L1.0280.98
26_G29_V1.0260.98
55_V58_V1.0180.98
64_A67_F1.0130.98
70_L73_R0.9970.98
68_L95_V0.9850.98
101_V105_L0.9770.98
116_L119_F0.9730.98
76_N86_P0.9720.98
1_L17_S0.9680.97
35_W39_E0.9610.97
37_Y131_R0.9510.97
14_G102_V0.9510.97
161_A165_F0.9500.97
32_A43_R0.9480.97
59_A63_L0.9450.97
124_L128_L0.9310.97
183_L188_P0.9270.97
94_L97_L0.9140.96
172_T203_R0.9070.96
35_W42_P0.9030.96
163_S166_A0.9000.96
149_V153_L0.8990.96
173_E199_R0.8960.96
52_A55_V0.8870.96
61_A65_V0.8740.95
29_V33_W0.8710.95
150_N155_R0.8690.95
178_Q187_S0.8630.95
173_E200_Q0.8600.95
142_V145_F0.8600.95
120_L124_L0.8540.95
13_Q20_S0.8480.95
34_L37_Y0.8470.95
181_S184_R0.8430.94
69_W93_L0.8410.94
161_A164_S0.8350.94
12_F16_L0.8310.94
12_F15_V0.8300.94
20_S23_I0.8280.94
135_V139_V0.8270.94
29_V32_A0.8260.94
169_D193_S0.8250.94
114_R117_V0.8180.93
65_V69_W0.8170.93
14_G17_S0.8120.93
18_G102_V0.8090.93
151_G202_R0.8080.93
44_P48_A0.8040.93
129_P132_V0.8030.93
162_D165_F0.8020.93
119_F122_R0.8010.93
128_L133_A0.7980.93
87_V92_P0.7970.93
140_L144_L0.7870.92
149_V154_V0.7790.92
117_V137_G0.7770.92
200_Q206_A0.7760.92
109_L112_L0.7730.91
186_G190_S0.7710.91
159_R163_S0.7700.91
73_R76_N0.7670.91
45_S109_L0.7670.91
182_P189_A0.7670.91
199_R206_A0.7630.91
157_A164_S0.7590.91
72_A92_P0.7560.90
48_A51_R0.7490.90
11_L14_G0.7460.90
14_G155_R0.7420.90
95_V99_A0.7420.90
145_F149_V0.7410.90
57_A61_A0.7410.90
136_V140_L0.7350.89
164_S167_A0.7240.88
2_T74_W0.7130.88
117_V154_V0.7120.88
180_T189_A0.7100.88
65_V101_V0.7070.87
4_S124_L0.7050.87
173_E176_V0.7000.87
72_A87_V0.7000.87
152_V156_G0.6970.87
193_S197_L0.6960.86
176_V206_A0.6930.86
92_P95_V0.6880.86
185_S192_V0.6850.86
79_R84_M0.6830.85
48_A52_A0.6790.85
80_A140_L0.6790.85
190_S201_G0.6790.85
58_V61_A0.6750.85
13_Q79_R0.6750.85
91_D95_V0.6750.85
67_F70_L0.6670.84
197_L200_Q0.6660.84
172_T200_Q0.6650.84
158_L162_D0.6650.84
32_A49_R0.6650.84
31_L44_P0.6640.84
113_L116_L0.6620.84
26_G30_L0.6620.84
113_L146_W0.6580.83
108_A112_L0.6560.83
104_A108_A0.6530.83
192_V196_S0.6510.83
168_V174_P0.6500.83
78_I131_R0.6450.82
59_A62_V0.6450.82
71_A78_I0.6360.81
46_P50_R0.6360.81
1_L32_A0.6340.81
120_L141_V0.6290.80
4_S8_R0.6230.80
4_S15_V0.6190.79
182_P205_V0.6170.79
74_W79_R0.6160.79
120_L177_P0.6160.79
8_R13_Q0.6160.79
1_L95_V0.6160.79
98_V101_V0.6150.79
200_Q207_S0.6150.79
156_G159_R0.6150.79
19_I36_R0.6120.79
21_A165_F0.6080.78
55_V59_A0.6080.78
102_V157_A0.6070.78
145_F148_L0.6070.78
172_T202_R0.6070.78
86_P108_A0.6060.78
168_V186_G0.6050.78
183_L186_G0.6050.78
96_L152_V0.6040.78
13_Q169_D0.6020.77
122_R130_R0.6000.77
17_S23_I0.5980.77
194_W205_V0.5930.76
58_V62_V0.5930.76
151_G172_T0.5900.76
6_L82_M0.5890.76
157_A162_D0.5860.76
13_Q16_L0.5860.76
89_T94_L0.5840.75
150_N154_V0.5830.75
69_W127_F0.5830.75
44_P47_R0.5820.75
57_A82_M0.5770.74
180_T183_L0.5760.74
116_L123_L0.5750.74
33_W37_Y0.5700.74
12_F27_L0.5690.73
89_T93_L0.5660.73
96_L185_S0.5650.73
12_F20_S0.5620.73
147_L151_G0.5600.72
114_R118_R0.5600.72
168_V171_L0.5600.72
85_E88_D0.5600.72
162_D166_A0.5590.72
129_P134_R0.5580.72
6_L169_D0.5570.72
90_A109_L0.5570.72
67_F77_S0.5570.72
93_L97_L0.5560.72
176_V199_R0.5550.72
65_V70_L0.5550.72
194_W198_G0.5540.71
139_V142_V0.5440.70
109_L139_V0.5440.70
23_I31_L0.5430.70
25_Y28_G0.5430.70
144_L147_L0.5420.70
194_W199_R0.5410.70
94_L98_V0.5400.70
22_A106_L0.5400.70
15_V94_L0.5380.69
97_L101_V0.5380.69
151_G156_G0.5370.69
66_L70_L0.5370.69
5_L34_L0.5350.69
74_W194_W0.5290.68
199_R203_R0.5250.67
203_R207_S0.5240.67
190_S198_G0.5230.67
84_M158_L0.5230.67
173_E192_V0.5230.67
204_F207_S0.5220.67
102_V197_L0.5220.67
13_Q18_G0.5190.67
15_V38_L0.5180.66
137_G149_V0.5180.66
37_Y136_V0.5180.66
164_S168_V0.5180.66
55_V62_V0.5160.66
126_R208_G0.5160.66
57_A158_L0.5160.66
68_L191_L0.5160.66
18_G78_I0.5150.66
14_G21_A0.5120.65
89_T140_L0.5090.65
56_L116_L0.5080.65
68_L89_T0.5080.65
20_S71_A0.5080.65
31_L143_V0.5070.65
61_A157_A0.5070.65
116_L141_V0.5030.64
6_L32_A0.5010.64
26_G114_R0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zeeA 3 0.2679 5.2 0.953 Contact Map
4eneA 2 0.6411 3.6 0.957 Contact Map
2fcgF 1 0.1196 2.5 0.96 Contact Map
2auhB 1 0.0957 2.1 0.962 Contact Map
1fryA 1 0.1388 1.8 0.963 Contact Map
3rqwA 4 0.3301 1.3 0.966 Contact Map
1pw4A 1 0.3828 1.3 0.966 Contact Map
3bz1X 1 0.177 1.1 0.967 Contact Map
4cofA 3 0.3445 1.1 0.967 Contact Map
2kt5B 1 0.1053 1.1 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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