GREMLIN Database
SLX9 - Ribosome biogenesis protein SLX9
PFAM: PF15341 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 124 (118)
Sequences: 603 (469)
Seq/√Len: 43.2
META: 0.207

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
96_E99_R3.1391.00
5_S8_E3.0971.00
120_H123_N2.7201.00
86_A89_K2.4411.00
31_K34_K2.2681.00
38_R44_V2.1481.00
84_G88_R2.1130.99
27_S31_K2.1080.99
28_A32_K2.0510.99
27_S30_K2.0380.99
14_H18_L2.0240.99
103_V109_F1.9690.99
87_K91_K1.9120.99
114_L117_I1.8890.99
109_F113_P1.8830.99
20_K33_K1.8520.99
25_S31_K1.7870.98
11_K15_E1.7600.98
25_S35_R1.7420.98
11_K17_F1.7310.98
108_A111_A1.6430.97
87_K121_L1.6360.97
60_G64_R1.5990.96
58_A61_A1.5760.96
25_S34_K1.5550.96
82_R85_A1.5130.95
119_Q123_N1.4820.94
68_Q71_K1.4500.94
107_P116_A1.4430.94
117_I121_L1.4140.93
70_G73_K1.4130.93
93_V97_R1.3270.90
39_P43_L1.3270.90
4_L19_S1.3130.90
106_H109_F1.3030.89
77_K80_K1.2810.89
27_S34_K1.2750.88
37_R41_K1.2700.88
17_F21_I1.2680.88
83_P87_K1.2680.88
8_E12_L1.2670.88
15_E18_L1.2630.88
85_A88_R1.2520.87
103_V113_P1.2120.86
82_R91_K1.1870.85
45_G53_A1.1710.84
118_R121_L1.1670.83
63_G66_Q1.1480.82
38_R41_K1.1430.82
4_L12_L1.1330.82
5_S9_K1.1220.81
60_G107_P1.1180.81
38_R43_L1.1160.81
112_N120_H1.0850.79
98_E102_K1.0760.78
6_K9_K1.0720.78
93_V103_V1.0580.77
41_K87_K1.0380.76
101_Q114_L1.0340.75
13_K17_F1.0110.74
103_V120_H1.0040.73
58_A62_K1.0000.73
103_V106_H0.9940.72
50_L81_S0.9820.71
61_A66_Q0.9730.71
46_D49_S0.9720.71
120_H124_T0.9600.70
90_K94_E0.9500.69
107_P120_H0.9400.68
83_P88_R0.9340.68
3_R11_K0.9290.67
17_F92_L0.9260.67
6_K21_I0.9180.66
25_S29_E0.9140.66
106_H123_N0.9140.66
7_K21_I0.9050.65
69_V74_K0.8830.63
110_Q119_Q0.8720.62
112_N122_S0.8680.62
30_K34_K0.8670.62
78_S84_G0.8670.62
9_K70_G0.8580.61
85_A89_K0.8540.61
41_K49_S0.8530.60
65_P68_Q0.8500.60
86_A93_V0.8370.59
103_V116_A0.8360.59
61_A65_P0.8340.59
112_N115_A0.8300.58
65_P73_K0.8270.58
32_K100_F0.8210.57
56_E107_P0.8170.57
6_K99_R0.8170.57
60_G65_P0.8140.57
58_A64_R0.8100.56
47_L79_L0.8100.56
92_L96_E0.8090.56
99_R121_L0.8070.56
19_S97_R0.8020.56
95_E99_R0.8020.56
87_K92_L0.7950.55
99_R103_V0.7800.54
100_F121_L0.7780.53
67_A71_K0.7770.53
71_K77_K0.7700.53
79_L100_F0.7650.52
25_S30_K0.7540.51
113_P121_L0.7500.51
49_S118_R0.7480.51
11_K62_K0.7420.50
8_E43_L0.7420.50
20_K64_R0.7410.50
115_A119_Q0.7320.49
59_E63_G0.7270.49
116_A120_H0.7090.47
106_H116_A0.7080.47
84_G87_K0.7070.47
65_P74_K0.7020.46
101_Q110_Q0.7020.46
101_Q105_A0.6990.46
97_R100_F0.6940.45
54_L100_F0.6810.44
60_G67_A0.6760.44
64_R68_Q0.6740.44
7_K16_A0.6670.43
89_K112_N0.6620.42
63_G68_Q0.6560.42
6_K55_P0.6550.42
18_L94_E0.6520.42
52_D55_P0.6520.42
14_H120_H0.6490.41
33_K37_R0.6470.41
17_F22_E0.6470.41
59_E67_A0.6380.40
78_S90_K0.6340.40
114_L118_R0.6260.39
101_Q104_L0.6250.39
43_L54_L0.6200.39
19_S53_A0.6190.38
9_K114_L0.6170.38
106_H120_H0.6020.37
3_R120_H0.6010.37
28_A31_K0.5960.36
5_S111_A0.5920.36
60_G66_Q0.5910.36
56_E73_K0.5820.35
70_G77_K0.5820.35
21_I55_P0.5770.35
47_L53_A0.5750.35
50_L55_P0.5750.35
67_A112_N0.5740.35
82_R88_R0.5720.34
79_L82_R0.5710.34
79_L89_K0.5640.34
60_G70_G0.5640.34
103_V110_Q0.5580.33
13_K45_G0.5550.33
68_Q72_I0.5540.33
99_R102_K0.5400.32
25_S53_A0.5370.31
39_P42_K0.5350.31
96_E116_A0.5330.31
15_E94_E0.5270.31
30_K49_S0.5240.30
63_G90_K0.5220.30
11_K48_D0.5200.30
35_R118_R0.5180.30
20_K32_K0.5140.30
116_A119_Q0.5130.29
4_L49_S0.5120.29
119_Q122_S0.5100.29
112_N118_R0.5100.29
59_E62_K0.5090.29
56_E72_I0.5060.29
43_L99_R0.5040.29
33_K63_G0.5010.29
52_D103_V0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lnmA 1 0.2984 7.6 0.911 Contact Map
1zxaA 1 0.2903 7.2 0.911 Contact Map
2llwA 1 0.3629 3.6 0.923 Contact Map
3gjxB 1 0.6371 2.8 0.927 Contact Map
3t98A 4 0.129 2.8 0.927 Contact Map
1a93A 1 0.1935 2.6 0.928 Contact Map
4ivgA 4 0.4113 2.6 0.929 Contact Map
3t0hA 2 0.2984 2.4 0.929 Contact Map
4r39A 1 0.2581 2.3 0.93 Contact Map
4nejA 1 0.629 2 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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